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Meg3 Gene Detail
Summary
  • Symbol
    Meg3
  • Name
    maternally expressed 3
  • Synonyms
    2900016C05Rik, 3110050O07Rik, 6330408G06Rik, D12Bwg1266e, Gtl2
  • Feature Type
    lncRNA gene
  • IDs
    MGI:1202886
    NCBI Gene: 17263
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
  • Regulated by
    Igdmr (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr12:109506879-109538163 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 60.25 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202886
 lncRNA gene Chr12:109506877-109538165 (+)
129S1/SvImJ MGP_129S1SvImJ_G0005408
 lincRNA gene Chr12:111766233-111800327 (+)
A/J MGP_AJ_G0005391
 lincRNA gene Chr12:107461904-107494902 (+)
AKR/J MGP_AKRJ_G0005371
 lincRNA gene Chr12:110596834-110631831 (+)
BALB/cJ MGP_BALBcJ_G0005373
 lincRNA gene Chr12:107934756-107968286 (+)
C3H/HeJ MGP_C3HHeJ_G0005322
 lincRNA gene Chr12:111040006-111073237 (+)
C57BL/6NJ MGP_C57BL6NJ_G0005527
 lincRNA gene Chr12:115182257-115219843 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0004912
 lincRNA gene Chr12:103989695-104020888 (+)
CAST/EiJ MGP_CASTEiJ_G0005266
 lincRNA gene Chr12:105987297-106024589 (+)
CBA/J MGP_CBAJ_G0005311
 lincRNA gene Chr12:119726418-119759298 (+)
DBA/2J MGP_DBA2J_G0005328
 lincRNA gene Chr12:107018650-107049871 (+)
FVB/NJ MGP_FVBNJ_G0005354
 lincRNA gene Chr12:105807160-105840547 (+)
LP/J MGP_LPJ_G0005410
 lincRNA gene Chr12:111594044-111627488 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0005336
 lincRNA gene Chr12:122874292-122909657 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0005528
 lincRNA gene Chr12:110076028-110111722 (+)
PWK/PhJ MGP_PWKPhJ_G0005215
 lincRNA gene Chr12:101624362-101657367 (+)
SPRET/EiJ MGP_SPRETEiJ_G0005136
 lincRNA gene Chr12:104247644-104279722 (+)
WSB/EiJ MGP_WSBEiJ_G0005316
 lincRNA gene Chr12:110990636-111026559 (+)



Homology
more
  • Human Ortholog
    MEG3, maternally expressed 3
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEG3, maternally expressed 3
  • Synonyms
    FP504, GTL2, LINC00023, NCRNA00023, onco-lncRNA-83, prebp1, PRO0518, PRO2160
  • Links
    NCBI Gene ID: 55384

  • Chr Location
    14q32.2; chr14:100779206-100861031 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 5 alleles in 6 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for disruptions in this gene show lethality and growth retardation that are dependent on the parental origin of the allele and the extent of the deletion of the associated differentially methylated region.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1278
  • Tissues
    235
  • cDNA Data
    78
  • Literature Summary
    65
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      154
    • RefSeq
      3
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17263 NCBI Gene Model | MGI Sequence Detail 31285 C57BL/6J ±  kb
    transcript NR_003633 RefSeq | MGI Sequence Detail 11488 ZRU/MplStud  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 130
      Genomic 8
      cDNA 86
      Primer pair 34
      Other 2

      Microarray probesets 15
    Other
    Accession IDs
    less
    MGD-MRK-32136, MGD-MRK-34035, MGI:105096, MGI:106343, MGI:1914508, MGI:1914551, MGI:1917961, MGI:2144809, MGI:2145004, MGI:2145132, MGI:2145137
    References
    more
    • Summaries
      All 127
      Developmental Gene Expression 65
      Phenotypes 15
    • Earliest
      J:30839 Schuster-Gossler K, et al., Gtl2lacZ, an insertional mutation on mouse chromosome 12 with parental origin-dependent phenotype. Mamm Genome. 1996 Jan;7(1):20-4
    • Latest
      J:369666 Guo J, et al., Single-cell transcriptome analysis reveals abnormal angiogenesis and placentation by loss of imprinted glutaminyl-peptide cyclotransferase. J Zhejiang Univ Sci B. 2025 Jun 15;26(6):589-608
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/24/2026
    MGI 6.24     		The Jackson Laboratory