About   Help   FAQ
Meg3 Gene Detail
Summary
  • Symbol
    Meg3
  • Name
    maternally expressed 3
  • Synonyms
    2900016C05Rik, 3110050O07Rik, 6330408G06Rik, D12Bwg1266e, Gtl2, Meg3
  • Feature Type
    lincRNA gene
  • IDs
    MGI:1202886
    NCBI Gene: 17263
Location & Maps
more
  • Sequence Map
    Chr12:109541001-109571726 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30726 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MEG3, maternally expressed 3 (non-protein coding)
  • Human Ortholog
    MEG3, maternally expressed 3 (non-protein coding)
    Orthology source: HGNC
  • Synonyms
    FP504, GTL2, LINC00023, NCRNA00023, onco-lncRNA-83, prebp1, PRO0518, PRO2160
  • Links
    NCBI Gene ID: 55384

  • Chr Location
    14q32; chr14:100826108-100861026 (+)  GRCh38.p2

  • HCOP
    human homology predictions: MEG3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 5 alleles in 6 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Targeted
    4
Mice heterozygous for disruptions in this gene show lethality and growth retardation that are dependent on the parental origin of the allele and the extent of the deletion of the associated differentially methylated region.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023027 VEGA Gene Model | MGI Sequence Detail 30726 C57BL/6J ±  kb
transcript NR_003633 RefSeq | MGI Sequence Detail 11488 C57BL/6  
polypeptide Q8CCV7 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    118 from dbSNP Build 137
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 106
    Genomic 8
    cDNA 81
    Primer pair 16
    Other 1

    Microarray probesets 15
Other
Accession IDs
less
MGD-MRK-32136, MGD-MRK-34035, MGI:105096, MGI:106343, MGI:1914508, MGI:1914551, MGI:1917961, MGI:2144809, MGI:2145004, MGI:2145132, MGI:2145137
References
more
  • Summaries
    All 81
    Developmental Gene Expression 44
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:30839 Schuster-Gossler K, et al., Gtl2lacZ, an insertional mutation on mouse chromosome 12 with parental origin-dependent phenotype. Mamm Genome. 1996 Jan;7(1):20-4
  • Latest
    J:218430 Kamimura S, et al., Establishment of paternal genomic imprinting in mouse prospermatogonia analyzed by nuclear transfer. Biol Reprod. 2014 Nov;91(5):120

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory