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Rhd Gene Detail
Summary
  • Symbol
    Rhd
  • Name
    Rh blood group, D antigen
  • Synonyms
    Rh, Rhced, Rhl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202882
    NCBI Gene: 19746
Location & Maps
more
  • Sequence Map
    Chr4:134864536-134896172 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31637 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 67.13 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RHCE, Rh blood group CcEe antigens
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RHCE, Rh blood group CcEe antigens
    Orthology source: HomoloGene
  • Synonyms
    CD240CE, RH, RH30A, Rh4, RHC, RHE, RhIVb(J), RHIXB, RHPI, RhVI, RhVIII
  • Links
    NCBI Gene ID: 6006
    neXtProt AC: NX_P18577

  • Chr Location
    1p36.11; chr1:25360659-25430192 (-)  GRCh38.p2

  • Human Ortholog
    RHD, Rh blood group D antigen
    Orthology source: HomoloGene
  • Synonyms
    CD240D, DIIIc, RH, RH30, Rh4, RHCED, RhDCw, RHDel, RHDVA(TT), RhII, RhK562-II, RhPI, RHPII, RHXIII
  • Links
    NCBI Gene ID: 6007
    neXtProt AC: NX_Q02161

  • Chr Location
    1p36.11; chr1:25272393-25330445 (+)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    2
  • Gene trapped
    16
  • Targeted
    5
  • Genomic Mutations
    4 involving Rhd
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased ammonium and methylammonium transport in red cell ghosts, reduced basal adhesion of red blood cells to endothelial cells, and a slight increase in iron levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011094 VEGA Gene Model | MGI Sequence Detail 31637 C57BL/6J ±  kb
transcript OTTMUST00000025966 VEGA | MGI Sequence Detail 1514 Not Applicable  
polypeptide OTTMUSP00000011894 VEGA | MGI Sequence Detail 418 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    364 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR001905 Ammonium transporter
    IPR024041 Ammonium transporter AmtB-like domain
    IPR029020 Ammonium/urea transporter
    IPR002229 Blood group Rhesus C/E/D polypeptide
Molecular
Reagents
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  • All nucleic 29
    Genomic 2
    cDNA 24
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1888985
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:49131 Kitano T, et al., Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene. Biochem Biophys Res Commun. 1998 Aug 10;249(1):78-85
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory