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Rhd
Gene Detail
 Symbol
Name
ID
Rhd
Rh blood group, D antigen
MGI:1202882
Synonyms Rh, Rhced, Rhl1
Feature Type protein coding gene
Genetic Map
Chromosome 4
67.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:134864536-134896172 bp, + strand
From VEGA annotation of GRCm38

  31637 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7918  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: erythrocyte membrane protein RhD
Gene Tree: Rhd

Human
homologs
Human Homolog RHCE, Rh blood group, CcEe antigens
NCBI Gene ID 6006
neXtProt AC  NX_P18577
Human Synonyms  CD240CE, RH, RH30A, Rh4, RHC, RHE, RhIVb(J), RHIXB, RHPI, RhVI, RhVIII
Human Chr (Location)  1p36.11; chr1:25361362-25420872 (-)  GRCh38
Human Homolog RHD, Rh blood group, D antigen
NCBI Gene ID 6007
neXtProt AC  NX_Q02161
Human Synonyms  CD240D, DIIIc, RH, RH30, Rh4, RHCED, RhDCw, RHDel, RHDVA(TT), RhII, RhK562-II, RhPI, RHPII, RHXIII
Human Chr (Location)  1p36.11; chr1:25272486-25330445 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(16) Targeted(4)
 
Mice homozygous for a knock-out allele exhibit decreased ammonium and methylammonium transport in red cell ghosts, reduced basal adhesion of red blood cells to endothelial cells, and a slight increase in iron levels.
 
Interactions
Rhd interacts with 26 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process ammonium transport, erythrocyte development, ...
Component integral component of membrane, membrane
Function ammonium transmembrane transporter activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (135)    Tissues (112)    Images (20)
Theiler Stages: 1, 2, 3, 5, 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 113
Northern blot 12
RT-PCR 10
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(2) cDNA(24) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000011094 (Evidence)
Ensembl Gene ModelENSMUSG00000028825 (Evidence)
Entrez Gene19746 (Evidence)
UniGene195461
DFCITC1576143
DoTSDT.110836110, DT.487679
NIA Mouse Gene IndexU004941
Consensus CDS ProjectCCDS18778.1
International Mouse Knockout Project StatusRhd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011094 VEGA Gene Model | MGI Sequence Detail 31637 C57BL/6J ±  kb
transcript OTTMUST00000025966 VEGA | MGI Sequence Detail 1514 Not Applicable 
polypeptide OTTMUSP00000011894 VEGA | MGI Sequence Detail 418 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(367 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024041 Ammonium transporter AmtB-like domain
InterPro IPR002229 Blood group Rhesus C/E/D polypeptide
Protein Ontology PR:000001442 blood group Rh(D) polypeptide
References (Earliest) J:49131 Kitano T, et al., Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene. Biochem Biophys Res Commun. 1998 Aug 10;249(1):78-85
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGI:1888985

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory