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Rhd Gene Detail
Summary
  • Symbol
    Rhd
  • Name
    Rh blood group, D antigen
  • Synonyms
    Rh, Rhced, Rhl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202882
    NCBI Gene: 19746
  • Gene Overview
    MyGene.info: RHD
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:134864536-134896172 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 67.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    364 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202882
protein coding gene Chr4:134864536-134896172 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028935
protein coding gene Chr4:137245099-137283229 (+)
A/J MGP_AJ_G0028894
protein coding gene Chr4:131471764-131503880 (+)
AKR/J MGP_AKRJ_G0028846
protein coding gene Chr4:135250894-135281992 (+)
BALB/cJ MGP_BALBcJ_G0028918
protein coding gene Chr4:132119726-132157226 (+)
C3H/HeJ MGP_C3HHeJ_G0028632
protein coding gene Chr4:135490149-135527642 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029359
protein coding gene Chr4:142189668-142228143 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026630
protein coding gene Chr4:124525533-124557051 (+)
CAST/EiJ MGP_CASTEiJ_G0028064
protein coding gene Chr4:133623517-133656581 (+)
CBA/J MGP_CBAJ_G0028597
protein coding gene Chr4:145963089-146002708 (+)
DBA/2J MGP_DBA2J_G0028746
protein coding gene Chr4:131888915-131925346 (+)
FVB/NJ MGP_FVBNJ_G0028713
protein coding gene Chr4:130802380-130836255 (+)
LP/J MGP_LPJ_G0028845
protein coding gene Chr4:137354965-137391051 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028739
protein coding gene Chr4:150408767-150440535 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029397
protein coding gene Chr4:135693691-135726388 (+)
PWK/PhJ MGP_PWKPhJ_G0027784
protein coding gene Chr4:128635964-128673816 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027610
protein coding gene Chr4:131518213-131554395 (+)
WSB/EiJ MGP_WSBEiJ_G0028142
protein coding gene Chr4:135863647-135899069 (+)



Homology
more
  • Human Ortholog
    RHCE, Rh blood group CcEe antigens
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RHCE, Rh blood group CcEe antigens
    Orthology source: HomoloGene
  • Synonyms
    CD240CE, RH, RH30A, Rh4, RHC, RHCe(152N), RHE, RhIVb(J), RHIXB, RHNA, RHPI, RhVI, RhVIII
  • Links
    NCBI Gene ID: 6006
    neXtProt AC: NX_P18577
    UniProt: P18577

  • Chr Location
    1p36.11; chr1:25362249-25430193 (-)  GRCh38.p7

  • Human Ortholog
    RHD, Rh blood group D antigen
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD240D, DIIIc, RH, RH30, Rh4, RHCED, RhDCw, RHDel, RHDVA(TT), RhII, RhK562-II, RhPI, RHPII, RHXIII
  • Links
    NCBI Gene ID: 6007
    neXtProt AC: NX_Q02161
    UniProt: Q02161

  • Chr Location
    1p36.11; chr1:25272393-25330445 (+)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased ammonium and methylammonium transport in red cell ghosts, reduced basal adhesion of red blood cells to endothelial cells, and a slight increase in iron levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19746 NCBI Gene Model | MGI Sequence Detail 31637 C57BL/6J ±  kb
    transcript NM_011270 RefSeq | MGI Sequence Detail 1530 Not Specified  
    polypeptide Q8CF94 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR024041 Ammonium transporter AmtB-like domain
      IPR029020 Ammonium/urea transporter
      IPR002229 Blood group Rhesus C/E/D polypeptide
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 2
      cDNA 25
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1888985
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:49131 Kitano T, et al., Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene. Biochem Biophys Res Commun. 1998 Aug 10;249(1):78-85
    • Latest
      J:209676 Goossens D, et al., Mice expressing RHAG and RHD human blood group genes. PLoS One. 2013;8(11):e80460

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory