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Cuzd1 Gene Detail
Summary
  • Symbol
    Cuzd1
  • Name
    CUB and zona pellucida-like domains 1
  • Synonyms
    ERG-1, Itmap1, UO-44, UTCZP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202881
    NCBI Gene: 16433
  • Gene Overview
    MyGene.info: CUZD1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:131308554-131322292 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 73.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202881
protein coding gene Chr7:131308554-131322292 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033099
protein coding gene Chr7:135927074-135944578 (-)
A/J MGP_AJ_G0033081
protein coding gene Chr7:132217955-132232986 (-)
AKR/J MGP_AKRJ_G0033013
protein coding gene Chr7:135725234-135740698 (-)
BALB/cJ MGP_BALBcJ_G0033082
protein coding gene Chr7:131907823-131921603 (-)
C3H/HeJ MGP_C3HHeJ_G0032796
protein coding gene Chr7:135579371-135596210 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033593
protein coding gene Chr7:141111023-141126279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030564
protein coding gene Chr7:133499035-133512409 (-)
CAST/EiJ MGP_CASTEiJ_G0032126
protein coding gene Chr7:127432125-127448235 (-)
CBA/J MGP_CBAJ_G0032769
protein coding gene Chr7:146009442-146022729 (-)
DBA/2J MGP_DBA2J_G0032921
protein coding gene Chr7:130202721-130216400 (-)
FVB/NJ MGP_FVBNJ_G0032874
protein coding gene Chr7:130070135-130083544 (-)
LP/J MGP_LPJ_G0033015
protein coding gene Chr7:137423609-137439605 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032906
protein coding gene Chr7:146933149-146946994 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033613
protein coding gene Chr7:134721069-134738470 (-)
PWK/PhJ MGP_PWKPhJ_G0031832
protein coding gene Chr7:123240358-123254809 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031678
protein coding gene Chr7:121497899-121511309 (-)
WSB/EiJ MGP_WSBEiJ_G0032237
protein coding gene Chr7:135622525-135637181 (-)



Homology
more
  • Human Ortholog
    CUZD1, CUB and zona pellucida like domains 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CUZD1, CUB and zona pellucida like domains 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERG1, ERG-1, ITMAP1, UO-44
  • Links
    NCBI Gene ID: 50624
    neXtProt AC: NX_Q86UP6
    UniProt: Q86UP6

  • Chr Location
    10q26.13; chr10:122832155-122846175 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Female mice homozygous for disruption of this gene exhibit impaired mammary gland development during puberty and during and following pregnancy and do not lactate. Homozygous mutant mice show an increased susceptibility to induced pancreatitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16433 NCBI Gene Model | MGI Sequence Detail 13739 C57BL/6J ±  kb
transcript NM_008411 RefSeq | MGI Sequence Detail 2270 C57BL/6  
polypeptide P70412 UniProt | EBI | MGI Sequence Detail 606 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR029834 CUB and zona pellucida-like domain-containing protein 1
    IPR000859 CUB domain
    IPR035914 Spermadhesin, CUB domain superfamily
    IPR001507 Zona pellucida domain
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:46397 Kasik JW, A cDNA cloned from pregnant mouse uterus exhibits temporo-spatial expression and predicts a novel protein. Biochem J. 1998 Mar 1;330(Pt 2):947-50
  • Latest
    J:242064 Mapes J, et al., CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy. PLoS Genet. 2017 Mar;13(3):e1006654

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory