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Cuzd1 Gene Detail
Summary
  • Symbol
    Cuzd1
  • Name
    CUB and zona pellucida-like domains 1
  • Synonyms
    ERG-1, Itmap1, UO-44, UTCZP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202881
    NCBI Gene: 16433
  • Gene Overview
    MyGene.info: CUZD1
Location & Maps
more
  • Sequence Map
    Chr7:131308554-131322292 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13739 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 73.81 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CUZD1, CUB and zona pellucida like domains 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CUZD1, CUB and zona pellucida like domains 1
    Orthology source: HomoloGene
  • Synonyms
    ERG1, ERG-1, ITMAP1, UO-44
  • Links
    NCBI Gene ID: 50624
    neXtProt AC: NX_Q86UP6

  • Chr Location
    10q26.13; chr10:122832155-122846175 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene have a normal phenotype. However, they show an increased sesceptibility to induced pancreatitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045956 VEGA Gene Model | MGI Sequence Detail 13739 C57BL/6J ±  kb
transcript OTTMUST00000120072 VEGA | MGI Sequence Detail 2256 Not Applicable  
polypeptide OTTMUSP00000066609 VEGA | MGI Sequence Detail 607 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    152 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006057 CUB and zona pellucida-like domain-containing protein 1
  • InterPro Domains
    IPR000859 CUB domain
    IPR001507 Zona pellucida domain
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:46397 Kasik JW, A cDNA cloned from pregnant mouse uterus exhibits temporo-spatial expression and predicts a novel protein. Biochem J. 1998 Mar 1;330(Pt 2):947-50
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory