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Traf4 Gene Detail
Summary
  • Symbol
    Traf4
  • Name
    TNF receptor associated factor 4
  • Synonyms
    A530032M13Rik, CART1, msp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202880
    NCBI Gene: 22032
  • Gene Overview
    MyGene.info: TRAF4
Location & Maps
more
  • Sequence Map
    Chr11:78158499-78165589 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7091 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM, cytoband B5-C
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TRAF4, TNF receptor associated factor 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRAF4, TNF receptor associated factor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CART1, MLN62, RNF83
  • Links
    NCBI Gene ID: 9618
    neXtProt AC: NX_Q9BUZ4

  • Chr Location
    17q11-q12; chr17:28744005-28750958 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 3 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    21
  • Targeted
    6
  • Genomic Mutations
    2 involving Traf4
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations show respiratory problems, various skeletal defects, spina bifida and partial lethality around embryonic day 14. Homozygotes for an ENU-induced mutation exhibit postnatal lethality and hypopigmentation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000106 VEGA Gene Model | MGI Sequence Detail 7091 C57BL/6J ±  kb
transcript OTTMUST00000000360 VEGA | MGI Sequence Detail 2078 Not Applicable  
polypeptide OTTMUSP00000000158 VEGA | MGI Sequence Detail 470 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 138
    cDNA 136
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2443728, MGI:3807535
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:46644 Masson R, et al., Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development. Mech Dev. 1998 Feb;71(1-2):187-91
  • Latest
    J:203947 Zhang L, et al., TRAF4 promotes TGF-beta receptor signaling and drives breast cancer metastasis. Mol Cell. 2013 Sep 12;51(5):559-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory