About   Help   FAQ
Meig1 Gene Detail
Summary
  • Symbol
    Meig1
  • Name
    meiosis expressed gene 1
  • Synonyms
    Meg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202878
    NCBI Gene: 104362
Location & Maps
more
Homology
more
  • Human Ortholog
    MEIG1, meiosis/spermiogenesis associated 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MEIG1, meiosis/spermiogenesis associated 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bA2K17.3, SPATA39
  • Links
    NCBI Gene ID: 644890
    neXtProt AC: NX_Q5JSS6

  • Chr Location
    10p13; chr10:14954228-14972857 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56414
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MEIG1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit male sterility with arrested spermatogenesis, absent sperm flagellum, and deformed sperm heads.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010782 VEGA Gene Model | MGI Sequence Detail 13606 C57BL/6J ±  kb
transcript OTTMUST00000025215 VEGA | MGI Sequence Detail 603 Not Applicable  
polypeptide OTTMUSP00000011564 VEGA | MGI Sequence Detail 88 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    108 from dbSNP Build 137
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010315 meiosis expressed gene 1 protein
  • InterPro Domains
    IPR020186 Meiosis-expressed gene 1 protein
Molecular
Reagents
less
  • All nucleic 148
    cDNA 147
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12188, MGI:96959
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:2557 Don J, et al., Identification and characterization of the regulated pattern of expression of a novel mouse gene, meg1, during the meiotic cell cycle. Cell Growth Differ. 1992 Aug;3(8):495-505
  • Latest
    J:194944 Teves ME, et al., Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. Andrology. 2013 Jan;1(1):37-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory