About   Help   FAQ
Meig1 Gene Detail
Summary
  • Symbol
    Meig1
  • Name
    meiosis expressed gene 1
  • Synonyms
    Meg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202878
    NCBI Gene: 104362
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:3409043-3422648 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 1.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202878
protein coding gene Chr2:3409043-3422648 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025307
protein coding gene Chr2:380029-393587 (-)
A/J MGP_AJ_G0025283
protein coding gene Chr2:360973-374578 (-)
AKR/J MGP_AKRJ_G0025252
protein coding gene Chr2:370311-383916 (-)
BALB/cJ MGP_BALBcJ_G0025279
protein coding gene Chr2:352184-365783 (-)
C3H/HeJ MGP_C3HHeJ_G0025039
protein coding gene Chr2:381064-394663 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025722
protein coding gene Chr2:374222-387827 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023136
protein coding gene Chr2:308401-322268 (-)
CAST/EiJ MGP_CASTEiJ_G0024503
protein coding gene Chr2:381537-395089 (-)
CBA/J MGP_CBAJ_G0025019
protein coding gene Chr2:400776-414381 (-)
DBA/2J MGP_DBA2J_G0025150
protein coding gene Chr2:345866-359471 (-)
FVB/NJ MGP_FVBNJ_G0025112
protein coding gene Chr2:354835-368907 (-)
LP/J MGP_LPJ_G0025237
protein coding gene Chr2:382608-396158 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025145
protein coding gene Chr2:376848-394365 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025780
protein coding gene Chr2:369585-383263 (-)
PWK/PhJ MGP_PWKPhJ_G0024252
protein coding gene Chr2:344560-358264 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024054
protein coding gene Chr2:398527-412073 (-)
WSB/EiJ MGP_WSBEiJ_G0024573
protein coding gene Chr2:377556-391161 (-)



Homology
more
  • Human Ortholog
    MEIG1, meiosis/spermiogenesis associated 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MEIG1, meiosis/spermiogenesis associated 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA2K17.3, SPATA39
  • Links
    NCBI Gene ID: 644890
    neXtProt AC: NX_Q5JSS6
    UniProt: Q5JSS6

  • Chr Location
    10p13; chr10:14959439-14972851 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56414
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MEIG1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male sterility with arrested spermatogenesis, absent sperm flagellum, and deformed sperm heads.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104362 NCBI Gene Model | MGI Sequence Detail 13606 C57BL/6J ±  kb
    transcript NM_001355205 RefSeq | MGI Sequence Detail 852 C57BL/6  
    polypeptide Q61845 UniProt | EBI | MGI Sequence Detail 88 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 151
      cDNA 148
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12188, MGI:96959
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:2557 Don J, et al., Identification and characterization of the regulated pattern of expression of a novel mouse gene, meg1, during the meiotic cell cycle. Cell Growth Differ. 1992 Aug;3(8):495-505
    • Latest
      J:240319 Stauber M, et al., Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev Biol. 2017 Mar 15;423(2):170-188

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/14/2019
    MGI 6.14
    The Jackson Laboratory