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Meig1 Gene Detail
Summary
  • Symbol
    Meig1
  • Name
    meiosis expressed gene 1
  • Synonyms
    Meg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202878
    NCBI Gene: 104362
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 2, 1.92 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MEIG1, meiosis/spermiogenesis associated 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MEIG1, meiosis/spermiogenesis associated 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA2K17.3, SPATA39
  • Links
    NCBI Gene ID: 644890
    neXtProt AC: NX_Q5JSS6
    UniProt: Q5JSS6

  • Chr Location
    10p13; chr10:14959439-14972851 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56414
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MEIG1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male sterility with arrested spermatogenesis, absent sperm flagellum, and deformed sperm heads.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000010782 VEGA Gene Model | MGI Sequence Detail 13606 C57BL/6J ±  kb
    transcript OTTMUST00000025215 VEGA | MGI Sequence Detail 603 Not Applicable  
    polypeptide OTTMUSP00000011564 VEGA | MGI Sequence Detail 88 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      108 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 150
      cDNA 147
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
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    MGD-MRK-12188, MGI:96959
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:2557 Don J, et al., Identification and characterization of the regulated pattern of expression of a novel mouse gene, meg1, during the meiotic cell cycle. Cell Growth Differ. 1992 Aug;3(8):495-505
    • Latest
      J:240319 Stauber M, et al., Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev Biol. 2017 Mar 15;423(2):170-188

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory