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Dgcr6 Gene Detail
Summary
  • Symbol
    Dgcr6
  • Name
    DiGeorge syndrome critical region gene 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202877
    NCBI Gene: 13353
  • Gene Overview
    MyGene.info: DGCR6
Location & Maps
more
  • Sequence Map
    Chr16:18052860-18071632 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18773 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.19 cM, cytoband B2
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    DGCR6, DiGeorge syndrome critical region gene 6
  • Vertebrate Orthologs
    4
  • Human Ortholog
    DGCR6, DiGeorge syndrome critical region gene 6
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 8214
    neXtProt AC: NX_Q14129

  • Chr Location
    22q11.21; chr22:18906223-18912088 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DGCR6 associations

Human Disease Mouse Models
       Velocardiofacial Syndrome   OMIM: 192430
Click on a disease name to see all genes associated with that disease.

  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotype references
  • All Mutations and Alleles
    12
  • Targeted
    12
  • Genomic Mutations
    9 involving Dgcr6
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028179 VEGA Gene Model | MGI Sequence Detail 18773 C57BL/6J ±  kb
transcript OTTMUST00000069810 VEGA | MGI Sequence Detail 1415 Not Applicable  
polypeptide OTTMUSP00000035508 VEGA | MGI Sequence Detail 233 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    48 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 80
    Genomic 29
    cDNA 50
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2146581
References
more
  • Summaries
    All 35
    Developmental Gene Expression 5
    Diseases 12
    Phenotypes 47
  • Earliest
    J:44451 Botta A, et al., Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation. Mamm Genome. 1997 Dec;8(12):890-5
  • Latest
    J:235630 Paronett EM, et al., Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation. Cereb Cortex. 2015 Oct;25(10):3977-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory