About   Help   FAQ
Tcf7l1 Gene Detail
Summary
  • Symbol
    Tcf7l1
  • Name
    transcription factor 7 like 1 (T cell specific, HMG box)
  • Synonyms
    Tcf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202876
    NCBI Gene: 21415
  • Gene Overview
    MyGene.info: TCF7L1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:72626371-72789045 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1032 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202876
protein coding gene Chr6:72626371-72789254 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030883
protein coding gene Chr6:73198349-73375802 (-)
A/J MGP_AJ_G0030853
protein coding gene Chr6:70354756-70521318 (-)
AKR/J MGP_AKRJ_G0030782
protein coding gene Chr6:72428943-72607878 (-)
BALB/cJ MGP_BALBcJ_G0030864
protein coding gene Chr6:70382275-70548037 (-)
C3H/HeJ MGP_C3HHeJ_G0030848
protein coding gene Chr6:111646005-111814120 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031322
protein coding gene Chr6:75110308-75279575 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028511
protein coding gene Chr6:69494165-69656461 (-)
CAST/EiJ MGP_CASTEiJ_G0029972
protein coding gene Chr6:72297239-72471246 (-)
CBA/J MGP_CBAJ_G0030551
protein coding gene Chr6:78187348-78367837 (-)
DBA/2J MGP_DBA2J_G0030703
protein coding gene Chr6:69745796-69908313 (-)
FVB/NJ MGP_FVBNJ_G0030656
protein coding gene Chr6:69139706-69303940 (-)
LP/J MGP_LPJ_G0030782
protein coding gene Chr6:73100081-73275220 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030691
protein coding gene Chr6:81556914-81734627 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031348
protein coding gene Chr6:72252657-72429172 (-)
PWK/PhJ MGP_PWKPhJ_G0029688
protein coding gene Chr6:68663140-68832591 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029516
protein coding gene Chr6:70996370-71168987 (-)
WSB/EiJ MGP_WSBEiJ_G0030054
protein coding gene Chr6:72624567-72800664 (-)



Homology
more
  • Human Ortholog
    TCF7L1, transcription factor 7 like 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TCF7L1, transcription factor 7 like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TCF3, TCF-3
  • Links
    NCBI Gene ID: 83439
    neXtProt AC: NX_Q9HCS4
    UniProt: Q9HCS4

  • Chr Location
    2p11.2; chr2:85133460-85310388 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7563
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TCF7L1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 6 alleles in 7 genetic backgrounds
    15 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Animals homozygous for a targeted mutation exhibit severe embryological defects particularly affecting the cardiovascular system, nervous system, and digestive system. No homozygous embryos survive beyond E11.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21415 NCBI Gene Model | MGI Sequence Detail 162675 C57BL/6J ±  kb
    transcript NM_001079822 RefSeq | MGI Sequence Detail 2882 C57BL/6  
    polypeptide Q9Z1J1 UniProt | EBI | MGI Sequence Detail 584 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR027397 Catenin binding domain superfamily
      IPR013558 CTNNB1 binding, N-teminal
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR028773 Transcription factor 7-like
      IPR024940 Transcription factor TCF/LEF
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 50
      Primer pair 4
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 116
      Developmental Gene Expression 64
      Gene Ontology 14
      Phenotypes 23
    • Earliest
      J:45934 Korinek V, et al., Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar;18(3):1248-56
    • Latest
      J:262044 Chodelkova O, et al., Tcf7L2 is essential for neurogenesis in the developing mouse neocortex. Neural Dev. 2018 May 11;13(1):8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory