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Tcf7l1
Gene Detail
Symbol

Name
ID
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
MGI:1202876
Synonyms
Tcf3
Feature Type
protein coding gene
Genetic Map
Chromosome 6
32.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:72626378-72789254 bp, - strand
From VEGA annotation of GRCm38

  162877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7563  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TCF7L1
Gene Tree: Tcf7l1

Human
homologs
TCF7L1, transcription factor 7-like 1 (T-cell specific, HMG-box)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 83439
neXtProt AC: NX_Q9HCS4

Human Synonyms: TCF3, TCF-3

Human Chr (Location): 2p11.2; chr2:85133460-85310388 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(130) : Gene trapped(123) Spontaneous(1) Targeted(6)
Genomic Mutations involving Tcf7l1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a targeted mutation exhibit severe embryological defects particularly affecting the cardiovascular system, nervous system, and digestive system. No homozygous embryos survive beyond E11.
 
Interactions
Tcf7l1 interacts with 211 markers (Mir15b, Mir16-2, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (54 records)
Data Summary: Results (412)    Tissues (309)    Images (68)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 32
RNA in situ 295
In situ reporter (knock in) 22
Northern blot 14
Western blot 2
RT-PCR 47
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tcf3, tcf7l1 ; ZFIN tcf7l1a, tcf7l1b    NEW 
Molecular
reagents
All nucleic(52) cDNA(48) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021200 (Evidence)
Ensembl Gene Model ENSMUSG00000055799 (Evidence)
Entrez Gene 21415 (Evidence)
UniGene 440067
DFCI TC1584027
DoTS DT.485681
NIA Mouse Gene Index U027481
Consensus CDS Project CCDS20245.1, CCDS39517.1
International Mouse Phenotyping Consortium Status Tcf7l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021200 VEGA Gene Model | MGI Sequence Detail 162877 C57BL/6J ±  kb
transcript OTTMUST00000050225 VEGA | MGI Sequence Detail 1888 Not Applicable 
polypeptide OTTMUSP00000065208 VEGA | MGI Sequence Detail 599 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(1035 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027397 Catenin binding domain
InterPro IPR013558 CTNNB1 binding, N-teminal
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR024940 Transcription factor TCF/LEF
Protein Ontology PR:000016185 transcription factor 7-like 1
References
(Earliest) J:45934 Korinek V, et al., Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar;18(3):1248-56
(Latest) J:221338 Hammond E, et al., The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci. 2015 Mar 25;35(12):5007-22
All references(99)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory