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Tcf7l1
Gene Detail
 Symbol
Name
ID
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
MGI:1202876
Synonyms Tcf3
Feature Type protein coding gene
Genetic Map
Chromosome 6
32.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:72626378-72789254 bp, - strand
From VEGA annotation of GRCm38

  162877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7563  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Tcf7l1

Human
homologs
Human Homolog TCF7L1, transcription factor 7-like 1 (T-cell specific, HMG-box)
NCBI Gene ID 83439
neXtProt AC  NX_Q9HCS4
Human Synonyms  TCF3, TCF-3
Human Chr (Location)  2p11.2; chr2:85133460-85310388 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(138) : Gene trapped(133) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a targeted mutation exhibit severe embryological defects particularly affecting the cardiovascular system, nervous system, and digestive system. No homozygous embryos survive beyond E11.
 
Interactions
Tcf7l1 interacts with 212 markers (Mir15b, Mir16-2, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process anterior/posterior axis specification, embryo, axial mesoderm morphogenesis, ...
Component nucleus, transcription factor complex
Function beta-catenin binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (366)    Tissues (298)    Images (36)
Theiler Stages: 2, 3, 4, 5, 9, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 295
Northern blot 14
Western blot 2
RT-PCR 47
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(48) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021200 (Evidence)
Ensembl Gene ModelENSMUSG00000055799 (Evidence)
Entrez Gene21415 (Evidence)
UniGene440067
DFCITC1584027
DoTSDT.485681
NIA Mouse Gene IndexU027481
Consensus CDS ProjectCCDS20245.1, CCDS39517.1
International Mouse Knockout Project StatusTcf7l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021200 VEGA Gene Model | MGI Sequence Detail 162877 C57BL/6J ±  kb
transcript OTTMUST00000050225 VEGA | MGI Sequence Detail 1888 Not Applicable 
polypeptide OTTMUSP00000065208 VEGA | MGI Sequence Detail 599 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(5)
Polymorphisms SNPs within 2kb(1035 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027397 Catenin binding domain
InterPro IPR013558 CTNNB1 binding, N-teminal
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR024940 Transcription factor TCF/LEF
Protein Ontology PR:000016185 transcription factor 7-like 1
References (Earliest) J:45934 Korinek V, et al., Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar;18(3):1248-56
(Latest) J:208262 Lien WH, et al., In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators. Nat Cell Biol. 2014 Feb;16(2):179-90
All references(95)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory