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Btf3 Gene Detail
Summary
  • Symbol
    Btf3
  • Name
    basic transcription factor 3
  • Synonyms
    1700054E11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202875
    NCBI Gene: 218490
  • Gene Overview
    MyGene.info: BTF3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:98309897-98317006 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 51.92 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202875
protein coding gene Chr13:98309896-98317006 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020865
protein coding gene Chr13:100009839-100016949 (-)
A/J MGP_AJ_G0020819
protein coding gene Chr13:96202717-96209844 (-)
AKR/J MGP_AKRJ_G0020793
protein coding gene Chr13:99140468-99147595 (-)
BALB/cJ MGP_BALBcJ_G0020817
protein coding gene Chr13:96906570-96913751 (-)
C3H/HeJ MGP_C3HHeJ_G0020608
protein coding gene Chr13:98879634-98886744 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021251
protein coding gene Chr13:103029172-103036282 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018821
protein coding gene Chr13:91951494-91958695 (-)
CAST/EiJ MGP_CASTEiJ_G0020127
protein coding gene Chr13:98248628-98255758 (-)
CBA/J MGP_CBAJ_G0020568
protein coding gene Chr13:107127447-107134574 (-)
DBA/2J MGP_DBA2J_G0020693
protein coding gene Chr13:95976625-95983752 (-)
FVB/NJ MGP_FVBNJ_G0020674
protein coding gene Chr13:94732476-94739683 (-)
LP/J MGP_LPJ_G0020768
protein coding gene Chr13:100116870-100123980 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020702
protein coding gene Chr13:107440558-107447668 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021292
protein coding gene Chr13:98591085-98598195 (-)
PWK/PhJ MGP_PWKPhJ_G0019880
protein coding gene Chr13:94782355-94789973 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019703
protein coding gene Chr13:94868826-94875858 (-)
WSB/EiJ MGP_WSBEiJ_G0020184
protein coding gene Chr13:99036136-99044164 (-)



Homology
more
  • Human Ortholog
    BTF3, basic transcription factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BTF3, basic transcription factor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BETA-NAC, BTF3a, BTF3b, NACB
  • Links
    NCBI Gene ID: 689
    neXtProt AC: NX_P20290
    UniProt: P20290

  • Chr Location
    5q13.2; chr5:73498425-73505623 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
A gene trap insertional mutation results in homozygous embryonic lethality shortly after implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 218490 NCBI Gene Model | MGI Sequence Detail 7110 C57BL/6J ±  kb
transcript NM_145455 RefSeq | MGI Sequence Detail 1108 Not Specified  
polypeptide Q64152 UniProt | EBI | MGI Sequence Detail 204 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 1
    cDNA 19
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1920694
References
more
  • Summaries
    All 35
    Developmental Gene Expression 7
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:28132 Deng JM, et al., An insertional mutation in the BTF3 transcription factor gene leads to an early postimplantation lethality in mice. Transgenic Res. 1995 Jul;4(4):264-9
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory