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Rhag
Gene Detail
 Symbol
Name
ID
Rhag
Rhesus blood group-associated A glycoprotein
MGI:1202713
Synonyms CD241, Rh50, Rh50A
Feature Type protein coding gene
Genetic Map
Chromosome 17
19.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:40811126-40840754 bp, + strand
From VEGA annotation of GRCm38

  29629 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68045  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: erythrocyte membrane protein RhD
Gene Tree: Rhag

Human
homologs
Human Homolog RHAG, Rh-associated glycoprotein
NCBI Gene ID 6005
neXtProt AC  NX_Q02094
Human Synonyms  CD241, RH2, Rh50, RH50A, Rh50GP, SLC42A1
Human Chr (Location)  6p12.3; chr6:49605175-49636874 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RHAG
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased ammonium and methylammonium transport in red cell ghosts, reduced basal adhesion of red blood cells to endothelial cells, a slight increase in iron levels, and decreased transferrin levels in males.
 
Interactions
Rhag interacts with 168 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process ammonium transmembrane transport, ammonium transport, ...
Component integral component of membrane, membrane, ...
Function ammonium transmembrane transporter activity, ankyrin binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (132)    Tissues (110)    Images (24)
Theiler Stages: 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 120
Northern blot 12
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026302 (Evidence)
Ensembl Gene ModelENSMUSG00000023926 (Evidence)
Entrez Gene19743 (Evidence)
UniGene12961
DFCITC1584091
DoTSDT.40170020
NIA Mouse Gene IndexU017984
Consensus CDS ProjectCCDS28787.1
International Mouse Knockout Project StatusRhag
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026302 VEGA Gene Model | MGI Sequence Detail 29629 C57BL/6J ±  kb
transcript OTTMUST00000065062 VEGA | MGI Sequence Detail 2339 Not Applicable 
polypeptide OTTMUSP00000032373 VEGA | MGI Sequence Detail 438 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(231 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024041 Ammonium transporter AmtB-like domain
InterPro IPR002229 Blood group Rhesus C/E/D polypeptide
Protein Ontology PR:000001554 ammonium transporter Rh type A
References (Earliest) J:49131 Kitano T, et al., Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene. Biochem Biophys Res Commun. 1998 Aug 10;249(1):78-85
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory