About   Help   FAQ
Rhag Gene Detail
Summary
  • Symbol
    Rhag
  • Name
    Rhesus blood group-associated A glycoprotein
  • Synonyms
    CD241, Rh50, Rh50A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202713
    NCBI Gene: 19743
  • Gene Overview
    MyGene.info: RHAG
Location & Maps
more
  • Sequence Map
    Chr17:40811126-40840754 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29629 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 19.54 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RHAG, Rh-associated glycoprotein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RHAG, Rh-associated glycoprotein
    Orthology source: HomoloGene
  • Synonyms
    CD241, OHS, OHST, RH2, Rh50, RH50A, Rh50GP, SLC42A1
  • Links
    NCBI Gene ID: 6005
    neXtProt AC: NX_Q02094

  • Chr Location
    6p12.3; chr6:49605175-49636874 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Rhag mouse models; 2 with human RHAG associations

Human Disease Mouse Models
       Rh-Null, Regulator Type; RHN   OMIM: 268150 View 2 "NOT" models
       Overhydrated Hereditary Stomatocytosis; OHST   OMIM: 185000
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Rhag
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased ammonium and methylammonium transport in red cell ghosts, reduced basal adhesion of red blood cells to endothelial cells, a slight increase in iron levels, and decreased transferrin levels in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026302 VEGA Gene Model | MGI Sequence Detail 29629 C57BL/6J ±  kb
transcript OTTMUST00000065062 VEGA | MGI Sequence Detail 2339 Not Applicable  
polypeptide OTTMUSP00000032373 VEGA | MGI Sequence Detail 438 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    231 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001554 ammonium transporter Rh type A
  • InterPro Domains
    IPR001905 Ammonium transporter
    IPR024041 Ammonium transporter AmtB-like domain
    IPR029020 Ammonium/urea transporter
    IPR002229 Blood group Rhesus C/E/D polypeptide
Molecular
Reagents
less
  • All nucleic 21
    cDNA 18
    Primer pair 1
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:49131 Kitano T, et al., Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene. Biochem Biophys Res Commun. 1998 Aug 10;249(1):78-85
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory