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Chrna9 Gene Detail
Summary
  • Symbol
    Chrna9
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 9
  • Synonyms
    2410015I05Rik, Acra9, Gm8311
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202403
    NCBI Gene: 231252
  • Gene Overview
    MyGene.info: CHRNA9
Location & Maps
more
  • Sequence Map
    Chr5:65934921-65977326 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42406 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 33.84 cM
  • Mapping Data
    4 experiments
Homology
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  • Human Ortholog
    CHRNA9, cholinergic receptor nicotinic alpha 9 subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHRNA9, cholinergic receptor nicotinic alpha 9 subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSA243342, NACHRA9
  • Links
    NCBI Gene ID: 55584
    neXtProt AC: NX_Q9UGM1

  • Chr Location
    4p14; chr4:40335329-40355217 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9729
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CHRNA9
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 4 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    43
  • Chemically induced (other)
    2
  • Gene trapped
    32
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    4 involving Chrna9
  • Incidental Mutations
Homozygous mutation of this gene results in abnormal innervation of the outer hair cells and depressed olivocochlear response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022200 VEGA Gene Model | MGI Sequence Detail 42406 C57BL/6J ±  kb
transcript OTTMUST00000052746 VEGA | MGI Sequence Detail 1843 Not Applicable  
polypeptide OTTMUSP00000025052 VEGA | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    136 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
    IPR002394 Nicotinic acetylcholine receptor
Molecular
Reagents
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  • All nucleic 10
    cDNA 8
    Other 2

    Microarray probesets 2
Other
Accession IDs
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MGI:1917242, MGI:3643549
References
more
  • Summaries
    All 49
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 36
  • Earliest
    J:30598 Glowatzki E, et al., Cell-specific expression of the alpha 9 n-ACh receptor subunit in auditory hair cells revealed by single-cell RT-PCR. Proc R Soc Lond B Biol Sci. 1995 Nov 22;262(1364):141-7
  • Latest
    J:220194 Smith ML, et al., Acetylcholine receptors in the retinas of the alpha7 nicotinic acetylcholine receptor knockout mouse. Mol Vis. 2014;20:1328-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory