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Pde7a Gene Detail
Summary
  • Symbol
    Pde7a
  • Name
    phosphodiesterase 7A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202402
    NCBI Gene: 18583
  • Gene Overview
    MyGene.info: PDE7A
Location & Maps
more
  • Sequence Map
    Chr3:19223108-19311322 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      88215 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 5.36 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PDE7A, phosphodiesterase 7A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDE7A, phosphodiesterase 7A
    Orthology source: HomoloGene
  • Synonyms
    HCP1, PDE7
  • Links
    NCBI Gene ID: 5150
    neXtProt AC: NX_Q13946

  • Chr Location
    8q13; chr8:65714334-65841734 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1956
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PDE7A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Gene trapped
    43
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Pde7a
  • Incidental Mutations
Homozygous inactivation of this locus does not impair T cell function but affects the humoral immune response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030206 VEGA Gene Model | MGI Sequence Detail 88215 C57BL/6J ±  kb
transcript OTTMUST00000074788 VEGA | MGI Sequence Detail 6298 Not Applicable  
polypeptide OTTMUSP00000039076 VEGA | MGI Sequence Detail 482 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    538 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000012484 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
  • EC
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR003607 HD/PDEase domain
Molecular
Reagents
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  • All nucleic 18
    cDNA 15
    Primer pair 3

    Microarray probesets 9
Other
Accession IDs
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MGI:2139861, MGI:2139950
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:49823 Bloom TJ, et al., Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14188-92
  • Latest
    J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory