About   Help   FAQ
Fgf17 Gene Detail
Summary
  • Symbol
    Fgf17
  • Name
    fibroblast growth factor 17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202401
    NCBI Gene: 14171
  • Gene Overview
    MyGene.info: FGF17
Location & Maps
more
  • Sequence Map
    Chr14:70636205-70642268 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6064 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.40 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FGF17, fibroblast growth factor 17
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FGF17, fibroblast growth factor 17
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FGF-13, FGF-17, HH20
  • Links
    NCBI Gene ID: 8822
    neXtProt AC: NX_O60258

  • Chr Location
    8p21.3; chr8:22039709-22048809 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FGF17 associations

Human Disease Mouse Models
       Hypogonadotropic Hypogonadism 20 with or without Anosmia; HH20   OMIM: 615270
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    19
  • Targeted
    3
  • Genomic Mutations
    1 involving Fgf17
  • Incidental Mutations
Mice homozygous for disruptions in this gene are grossly normal at birth and apparently healthy at birth. However, there are tissue losses in the inferior colliculus and the anterior vermis of the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022101 Ensembl Gene Model | MGI Sequence Detail 6064 C57BL/6J ±  kb
transcript ENSMUST00000022697 Ensembl | MGI Sequence Detail 1687 Not Applicable  
polypeptide ENSMUSP00000022697 Ensembl | MGI Sequence Detail 216 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    47 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 1
    cDNA 13
    Primer pair 4
    Other 3

    Microarray probesets 4
References
more
  • Summaries
    All 104
    Developmental Gene Expression 77
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:46389 Hoshikawa M, et al., Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain. Biochem Biophys Res Commun. 1998 Mar 6;244(1):187-91
  • Latest
    J:231094 Du W, et al., Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016 Mar;20(2):81-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory