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Supt5
Gene Detail
 Symbol
Name
ID
Supt5
suppressor of Ty 5
MGI:1202400
Synonyms Spt5, Supt5h
Feature Type protein coding gene
Genetic Map
Chromosome 7
16.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:28314898-28338719 bp, - strand
From Ensembl annotation of GRCm38

  23822 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription elongation factor Spt5
Gene Tree: Supt5

Human
homologs
Human Homolog SUPT5H, suppressor of Ty 5 homolog (S. cerevisiae)
NCBI Gene ID 6829
neXtProt AC  NX_O00267
Human Synonyms  SPT5, SPT5H, Tat-CT1
Human Chr (Location)  19q13; chr19:39445546-39476670 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(23) Targeted(6)
Incidental mutations (data from APF )
Interactions
Supt5 interacts with 60 markers (Mir15a, Mir99a, Mir103-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process DNA-templated transcription, elongation, negative regulation of DNA-templated transcription, elongation, ...
Component DSIF complex, nucleus
Function chromatin binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (110)    Tissues (56)    Images (24)
Theiler Stages: 17, 19, 21, 23, 27
Assay TypeResults
RNA in situ 110
cDNA source data(233)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(235) Genomic(1) cDNA(234)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000003435 (Evidence)
Entrez Gene20924 (Evidence)
UniGene285906
DFCITC1573270, TC1640874
DoTSDT.101189865, DT.101291679, DT.101321921, DT.494750, DT.97356368
NIA Mouse Gene IndexU028321
Consensus CDS ProjectCCDS39857.1
International Mouse Knockout Project StatusSupt5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003435 Ensembl Gene Model | MGI Sequence Detail 23822 C57BL/6J ±  kb
transcript ENSMUST00000003527 Ensembl | MGI Sequence Detail 3509 Not Applicable 
polypeptide ENSMUSP00000003527 Ensembl | MGI Sequence Detail 1082 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005824 KOW
InterPro IPR024945 Spt5 C-terminal domain
InterPro IPR022581 Spt5 transcription elongation factor, N-terminal
InterPro IPR006645 Transcription antitermination protein, NusG, N-terminal
InterPro IPR017071 Transcription elongation factor Spt5
InterPro IPR005100 Transcription elongation factor Spt5, NGN domain
InterPro IPR008991 Translation protein SH3-like domain
Protein Ontology PR:000015836 transcription elongation factor SPT5
References (Earliest) J:46084 Chiang PW, et al., Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6. Genomics. 1998 Feb 1;47(3):426-8
(Latest) J:173556 Flynn RA, et al., Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10460-5
All references(39)
Other
accession IDs
MGI:2142099, MGI:2142103, MGI:2142130

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory