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Kera
Gene Detail
 Symbol
Name
ID
Kera
keratocan
MGI:1202398
Synonyms CNA2, SLRR2B
Feature Type protein coding gene
Genetic Map
Chromosome 10
50.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:97607205-97613688 bp, + strand
From NCBI annotation of GRCm38

  6484 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5106  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: class II small leucine-rich proteoglycan
Gene Tree: Kera

Human
homologs
Human Homolog KERA, keratocan
NCBI Gene ID 11081
neXtProt AC  NX_O60938
Human Synonyms  CNA2, KTN, SLRR2B
Human Chr (Location)  12q22; chr12:91050491-91058354 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KERA
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Mice homozygous for disruptions in this gene have a thinner than normal corneal stroma with thicker collagen fibers which were less regularly packed.
 
Human Diseases Modeled Using Mouse Kera (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Kera interacts with 139 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process cornea development in camera-type eye
Component extracellular region, proteinaceous extracellular matrix
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (95)    Tissues (46)    Images (39)
Theiler Stages: 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 92
Northern blot 3
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000019932 (Evidence)
Entrez Gene16545 (Evidence)
UniGene6228
DFCITC1583963
DoTSDT.50315845
NIA Mouse Gene IndexU011937
Consensus CDS ProjectCCDS36044.1
International Mouse Knockout Project StatusKera
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16545 NCBI Gene Model | MGI Sequence Detail 6484 C57BL/6J ±  kb
transcript NM_008438 RefSeq | MGI Sequence Detail 1950 C57BL/6 
polypeptide O35367 UniProt | EBI | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(4) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
Protein Ontology PR:000009278 keratocan
Graphical View of Protein Domain Structure
References (Earliest) J:46658 Dunlevy JR, et al., Cloning and chromosomal localization of mouse keratocan, a corneal keratan sulfate proteoglycan. Mamm Genome. 1998 Apr;9(4):316-9
(Latest) J:181974 Seo S, et al., Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2015-20
All references(41)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory