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Kera
Gene Detail
Symbol

Name
ID
Kera
keratocan
MGI:1202398
Synonyms
CNA2, SLRR2B
Feature Type
protein coding gene
Genetic Map
Chromosome 10
50.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:97607205-97613688 bp, + strand
From Ensembl annotation of GRCm38

  6484 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5106  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: class II small leucine-rich proteoglycan
Gene Tree: Kera

Human
homologs
Human Homolog KERA, keratocan
NCBI Gene ID 11081
neXtProt AC  NX_O60938
Human Synonyms  CNA2, KTN, SLRR2B
Human Chr (Location)  12q22; chr12:91050491-91058354 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KERA
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Mice homozygous for disruptions in this gene have a thinner than normal corneal stroma with thicker collagen fibers which were less regularly packed.
 
Human Diseases Modeled Using Mouse Kera (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Kera interacts with 139 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process cornea development in camera-type eye
Component extracellular region, proteinaceous extracellular matrix
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (95)    Tissues (46)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 92
Northern blot 3
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000019932 (Evidence)
Entrez Gene16545 (Evidence)
UniGene6228
DFCITC1583963
DoTSDT.50315845
NIA Mouse Gene IndexU011937
Consensus CDS ProjectCCDS36044.1
International Mouse Knockout Project StatusKera
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019932 Ensembl Gene Model | MGI Sequence Detail 6484 C57BL/6J ±  kb
transcript ENSMUST00000105286 Ensembl | MGI Sequence Detail 1950 Not Applicable 
polypeptide ENSMUSP00000100923 Ensembl | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
Protein Ontology PR:000009278 keratocan
References
(Earliest) J:46658 Dunlevy JR, et al., Cloning and chromosomal localization of mouse keratocan, a corneal keratan sulfate proteoglycan. Mamm Genome. 1998 Apr;9(4):316-9
(Latest) J:213109 Chen S, et al., The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly. FEBS J. 2013 May;280(10):2120-37
All references(43)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory