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Ints6 Gene Detail
Summary
  • Symbol
    Ints6
  • Name
    integrator complex subunit 6
  • Synonyms
    2900075H24Rik, Ddx26, DICE1, Notch2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202397
    NCBI Gene: 18130
  • Gene Overview
    MyGene.info: INTS6
Location & Maps
more
  • Sequence Map
    Chr14:62676330-62761112 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      84783 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.23 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    INTS6, integrator complex subunit 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    INTS6, integrator complex subunit 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2
  • Links
    NCBI Gene ID: 26512
    neXtProt AC: NX_Q9UL03

  • Chr Location
    13q14.3; chr13:51353862-51453236 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    11 phenotype references
  • All Mutations and Alleles
    108
  • Chemically induced (other)
    1
  • Gene trapped
    106
  • Transgenic
    1
  • Genomic Mutations
    1 involving Ints6
  • Incidental Mutations
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035161 Ensembl Gene Model | MGI Sequence Detail 84783 C57BL/6J ±  kb
transcript ENSMUST00000053959 Ensembl | MGI Sequence Detail 4993 Not Applicable  
polypeptide ENSMUSP00000086788 Ensembl | MGI Sequence Detail 883 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    351 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009075 integrator complex subunit 6
  • InterPro Domains
    IPR029307 INTS6/SAGE1/DDX26B/CT45, C-terminal
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 6
Other
Accession IDs
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MGI:1920288, MGI:2145666
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:45989 Hoff HB 3rd, et al., DBI-1, a novel gene related to the notch family, modulates mitogenic response to insulin-like growth factor 1. Exp Cell Res. 1998 Feb 1;238(2):359-70
  • Latest
    J:169836 Lachke SA, et al., Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25;331(6024):1571-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory