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Gif Gene Detail
Summary
  • Symbol
    Gif
  • Name
    gastric intrinsic factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202394
    NCBI Gene: 14603
  • Gene Overview
    MyGene.info: CBLIF
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11747554-11763447 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 8.51 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202394
protein coding gene Chr19:11747543-11763447 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024884
protein coding gene Chr19:9133448-9151957 (+)
A/J MGP_AJ_G0024858
protein coding gene Chr19:8623304-8640721 (+)
AKR/J MGP_AKRJ_G0024833
protein coding gene Chr19:8949298-8965304 (+)
BALB/cJ MGP_BALBcJ_G0024858
protein coding gene Chr19:8626261-8642085 (+)
C3H/HeJ MGP_C3HHeJ_G0024624
protein coding gene Chr19:8845841-8863034 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025306
protein coding gene Chr19:9586524-9602819 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022732
protein coding gene Chr19:9210230-9226820 (+)
CAST/EiJ MGP_CASTEiJ_G0024097
protein coding gene Chr19:8442876-8458057 (+)
CBA/J MGP_CBAJ_G0024598
protein coding gene Chr19:9654557-9670899 (+)
DBA/2J MGP_DBA2J_G0024725
protein coding gene Chr19:8588316-8603817 (+)
FVB/NJ MGP_FVBNJ_G0024692
protein coding gene Chr19:8620337-8635588 (+)
LP/J MGP_LPJ_G0024812
protein coding gene Chr19:9138458-9154847 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024719
protein coding gene Chr19:9564500-9580653 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025354
protein coding gene Chr19:8933232-8948965 (+)
PWK/PhJ MGP_PWKPhJ_G0023841
protein coding gene Chr19:8054628-8070990 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023647
protein coding gene Chr19:8106533-8123724 (+)
WSB/EiJ MGP_WSBEiJ_G0024159
protein coding gene Chr19:8783196-8799710 (+)



Homology
more
  • Human Ortholog
    CBLIF, cobalamin binding intrinsic factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CBLIF, cobalamin binding intrinsic factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GIF, IF, IFMH, INF, TCN3
  • Links
    NCBI Gene ID: 2694
    neXtProt AC: NX_P27352
    UniProt: P27352

  • Chr Location
    11q12.1; chr11:59829268-59845529 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CBLIF associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit vitamin B12-sensitive susceptibility to bacterial infection and reduced body weight and altered blood chemistry that can be compensated by maternal effect.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024682 Ensembl Gene Model | MGI Sequence Detail 15894 C57BL/6J ±  kb
    transcript ENSMUST00000025585 Ensembl | MGI Sequence Detail 1537 Not Applicable  
    polypeptide ENSMUSP00000025585 Ensembl | MGI Sequence Detail 417 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 2
      cDNA 5
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147670
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 13
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:46934 Lorenz RG, et al., Use of transgenic mice to study regulation of gene expression in the parietal cell lineage of gastric units. J Biol Chem. 1993 Dec 15;268(35):26559-70
    • Latest
      J:263185 Huang M, et al., Multiple roles of epithelial heparan sulfate in stomach morphogenesis. J Cell Sci. 2018 May 29;131(10)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory