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Gif
Gene Detail
Symbol

Name
ID
Gif
gastric intrinsic factor
MGI:1202394
Feature Type
protein coding gene
Genetic Map
Chromosome 19
8.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:11747554-11763447 bp, + strand
From VEGA annotation of GRCm38

  15894 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3773  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: GIF
Protein SuperFamily: gastric intrinsic factor
Gene Tree: Gif

Human
homologs
GIF, gastric intrinsic factor (vitamin B synthesis)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2694
neXtProt AC: NX_P27352

Human Synonyms: IF, IFMH, INF, TCN3

Human Chr (Location): 11q13; chr11:59829268-59845537 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GIF

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gif interacts with 41 markers (Mir24-1, Mir24-2, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cobalamin metabolic process, cobalamin transport, ...
Component apical plasma membrane, endosome, ...
Function cobalamin binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(2) cDNA(4) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026377 (Evidence)
Ensembl Gene Model ENSMUSG00000024682 (Evidence)
Entrez Gene 14603 (Evidence)
UniGene 456
DFCI TC1586629
DoTS DT.40140164
NIA Mouse Gene Index U019178
Consensus CDS Project CCDS29609.1
International Mouse Phenotyping Consortium Status Gif
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026377 VEGA Gene Model | MGI Sequence Detail 15894 C57BL/6J ±  kb
transcript OTTMUST00000065230 VEGA | MGI Sequence Detail 1537 Not Applicable 
polypeptide OTTMUSP00000032480 VEGA | MGI Sequence Detail 417 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002157 Cobalamin (vitamin B12)-binding transporter, eukaryotic
Protein Ontology PR:000007975 gastric intrinsic factor
References
(Earliest) J:46934 Lorenz RG, et al., Use of transgenic mice to study regulation of gene expression in the parietal cell lineage of gastric units. J Biol Chem. 1993 Dec 15;268(35):26559-70
(Latest) J:176833 Kim TH, et al., Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med. 2011 Apr 11;208(4):677-88
All references(37)
Other
accession IDs
MGI:2147670

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory