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Gpaa1 Gene Detail
Summary
  • Symbol
    Gpaa1
  • Name
    GPI anchor attachment protein 1
  • Synonyms
    mGAA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202392
    NCBI Gene: 14731
  • Gene Overview
    MyGene.info: GPAA1
Location & Maps
more
  • Sequence Map
    Chr15:76331231-76334907 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3677 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 35.72 cM, cytoband E
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GPAA1, glycosylphosphatidylinositol anchor attachment 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPAA1, glycosylphosphatidylinositol anchor attachment 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GAA1, hGAA1
  • Links
    NCBI Gene ID: 8733
    neXtProt AC: NX_O43292

  • Chr Location
    8q24.3; chr8:144082621-144086216 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotype references
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    3
  • Gene trapped
    4
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    5 involving Gpaa1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035761 VEGA Gene Model | MGI Sequence Detail 3677 C57BL/6J ±  kb
transcript OTTMUST00000091481 VEGA | MGI Sequence Detail 2107 Not Applicable  
polypeptide OTTMUSP00000050393 VEGA | MGI Sequence Detail 621 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    35 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008158 glycosylphosphatidylinositol anchor attachment 1 protein
  • InterPro Domains
    IPR007246 GPI transamidase component Gaa1
Molecular
Reagents
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  • All nucleic 174
    Genomic 2
    cDNA 172

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146295
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 28
  • Earliest
    J:45545 Hiroi Y, et al., Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins. FEBS Lett. 1998 Jan 16;421(3):252-8
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory