Drc4 MGI Mouse Gene Detail - MGI:1202386 - dynein regulatory complex subunit 4

Symbol

Drc4
Name

dynein regulatory complex subunit 4
Synonyms

Gas11, Gas8

Feature Type

protein coding gene
IDs

MGI:1202386
NCBI Gene: 104346
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr8:124245630-124263394 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 72.10 cM, cytoband E2
Mapping Data

1 experiment

SNPs within 2kb

527 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1202386	protein coding gene	Chr8:124245573-124263394 (+)
129S1/SvImJ	ENSMUSG00200042564	protein coding gene	Chr8:118556366-118574181 (+)
A/J	ENSMUSG00195025539	protein coding gene	Chr8:118858936-118876754 (+)
AKR/J	ENSMUSG00220039867	protein coding gene	Chr8:119045421-119063235 (+)
BALB/cJ	ENSMUSG00180024500	protein coding gene	Chr8:118904907-118922726 (+)
C3H/HeJ	ENSMUSG00175028646	protein coding gene	Chr8:118957334-118975147 (+)
C57BL/6NJ	ENSMUSG00215015794	protein coding gene	Chr8:118551893-118569711 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031694	protein coding gene	Chr8:114677908-114696915 (+)
CAST/EiJ	ENSTCUG00005033791	protein coding gene	Chr8:118282557-118300443 (+)
CBA/J	ENSMUSG00210033332	protein coding gene	Chr8:118884402-118902217 (+)
DBA/2J	ENSMUSG00185034638	protein coding gene	Chr8:124989359-125007173 (+)
FVB/NJ	ENSMUSG00205029467	protein coding gene	Chr8:117852838-117870652 (+)
JF1/MsJ	ENSUMUG00000023100	protein coding gene	Chr8:127300031-127317921 (+)
LP/J	ENSMUSG00230028857	protein coding gene	Chr8:128607738-128625553 (+)
NOD/ShiLtJ	ENSMUSG00190018761	protein coding gene	Chr8:118996055-119013871 (+)
NZO/HlLtJ	ENSMUSG00225019737	protein coding gene	Chr8:132000937-132018754 (+)
PWK/PhJ	ENSLUMG00010033828	protein coding gene	Chr8:118704375-118722124 (+)
SPRET/EiJ	ENSMSPG00010033086	protein coding gene	Chr8:120894150-120913306 (+)
WSB/EiJ	ENSIUOG00005028126	protein coding gene	Chr8:119689079-119706895 (+)

Human Ortholog

DRC4, dynein regulatory complex subunit 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DRC4, dynein regulatory complex subunit 4
Synonyms

CILD33, GAS11, GAS8
Links

HGNC:4166

NCBI Gene ID: 2622

UniProt: O95995
Chr Location

16q24.3; chr16:90019629-90044975 (+) GRCh38

MGI Vertebrate Homology

Drc4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DRC4
Gene Tree

Drc4

Diseases

1 with Drc4 mouse models; 1 with human DRC4 associations

Human Disease

Mouse Models

primary ciliary dyskinesia 33

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Gene trapped

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit postnatal lethality, severe hydrocephaly, situs inversus with levocardia and abnormal cilia morphology and function.

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All GO Annotations

75
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

650
Tissues

11
cDNA Data

37
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase drc4

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All Sequences

47
RefSeq

11
UniProt

4
CCDS

CCDS40512.1

Ensembl

ENSMUSG00000040220 (Evidence)
NCBI Gene

104346

			Length	Strain/Species	Flank
genomic	104346	NCBI Gene Model \| MGI Sequence Detail	17765	C57BL/6J	± kb
transcript	NR_189740	RefSeq \| MGI Sequence Detail	1708	C57BL/6
polypeptide	Q60779	UniProt \| EBI \| MGI Sequence Detail	478	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007855 dynein regulatory complex subunit 4

(term hierarchy)
InterPro Domains

IPR039308 Growth arrest-specific protein 8

IPR025593 Growth arrest-specific protein 8 domain

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All nucleic 38

Genomic 1

cDNA 37

Antibodies 1

Microarray probesets 4

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MGI:1933195, MGI:8348355

Summaries

All 45

Developmental Gene Expression 3

Diseases 1

Gene Ontology 16

Phenotypes 5
Earliest

J:46329 Brenner DG, et al., Analysis of mammalian cell genetic regulation in situ by using retrovirus-derived portable exons carrying the Escherichia coli lacZ gene. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5517-21
Latest

J:373993 Ren C, et al., Core N-DRC components play a crucial role in embryonic development and postnatal organ development. Cell Death Dis. 2025 Mar 15;16(1):176

TSS for Drc4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79978	Chr8:124245582-124245667 (+)	-5 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24