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Phlda2 Gene Detail
Summary
  • Symbol
    Phlda2
  • Name
    pleckstrin homology like domain, family A, member 2
  • Synonyms
    Ipl, Tssc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202307
    NCBI Gene: 22113
  • Gene Overview
    MyGene.info: PHLDA2
Location & Maps
more
  • Sequence Map
    Chr7:143501545-143503150 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1606 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.23 cM
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    PHLDA2, pleckstrin homology like domain family A member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PHLDA2, pleckstrin homology like domain family A member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BRW1C, BWR1C, HLDA2, IPL, TSSC3
  • Links
    NCBI Gene ID: 7262
    neXtProt AC: NX_Q53GA4

  • Chr Location
    11p15.4; chr11:2928273-2929420 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 1 genetic background
    6 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    3
  • Targeted
    5
  • Transgenic
    1
Mice homozygous for disruptions in this gene have enlarged placentas but display little change in fetal weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024031 VEGA Gene Model | MGI Sequence Detail 1606 C57BL/6J ±  kb
transcript OTTMUST00000058758 VEGA | MGI Sequence Detail 757 Not Applicable  
polypeptide OTTMUSP00000028511 VEGA | MGI Sequence Detail 144 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    16 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012664 pleckstrin homology-like domain family A member 2
  • InterPro Domains
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
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  • All nucleic 59
    Genomic 11
    cDNA 39
    Primer pair 7
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 71
    Developmental Gene Expression 34
    Diseases 1
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
  • Latest
    J:228795 Tunster SJ, et al., The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Dev Biol. 2016 Jan 1;409(1):251-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory