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Kcnu1
Gene Detail
Symbol

Name
ID
Kcnu1
potassium channel, subfamily U, member 1
MGI:1202300
Synonyms
Kcnma3, Slo3
Feature Type
protein coding gene
Genetic Map
Chromosome 8
14.17 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:25849623-25937933 bp, + strand
From VEGA annotation of GRCm38

  88311 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7392  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: KCNU1
Protein SuperFamily: calcium-activated potassium channel, alpha subunit
Gene Tree: Kcnu1

Human
homologs
KCNU1, potassium channel, subfamily U, member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 157855
neXtProt AC: NX_A8MYU2

Human Synonyms: KCa5, KCa5.1, Kcnma3, KCNMC1, Slo3

Human Chr (Location): 8p11.23; chr8:36784324-36936125 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(8) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous male mutants are infertile with impaired sperm capacitation.
 
Interactions
Kcnu1 interacts with 17 markers (Mir30b, Mir135a-1, Mir135a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function calcium-activated potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 2
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031857 (Evidence)
Ensembl Gene Model ENSMUSG00000031576 (Evidence)
Entrez Gene 16532 (Evidence)
UniGene 289679
DFCI TC1650194, TC1632833, TC1606552
DoTS DT.97408171, DT.101201937, DT.101143773
NIA Mouse Gene Index U009206
Consensus CDS Project CCDS52530.1
International Mouse Phenotyping Consortium Status Kcnu1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031857 VEGA Gene Model | MGI Sequence Detail 88311 C57BL/6J ±  kb
transcript OTTMUST00000078991 VEGA | MGI Sequence Detail 3529 Not Applicable 
polypeptide OTTMUSP00000042086 VEGA | MGI Sequence Detail 1121 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(289 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR003929 Potassium channel, calcium-activated, BK, alpha subunit
InterPro IPR003091 Voltage-dependent potassium channel
Protein Ontology PR:000009271 potassium channel subfamily U member 1
References
(Earliest) J:45626 Schreiber M, et al., Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. J Biol Chem. 1998 Feb 6;273(6):3509-16
(Latest) J:218100 Chavez JC, et al., SLO3 K+ channels control calcium entry through CATSPER channels in sperm. J Biol Chem. 2014 Nov 14;289(46):32266-75
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory