About   Help   FAQ
Kcnu1 Gene Detail
Summary
  • Symbol
    Kcnu1
  • Name
    potassium channel, subfamily U, member 1
  • Synonyms
    Kcnma3, Slo3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202300
    NCBI Gene: 16532
  • Gene Overview
    MyGene.info: KCNU1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:25849623-25937939 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 14.17 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202300
protein coding gene Chr8:25848627-25937943 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033491
protein coding gene Chr8:23923114-24013285 (+)
A/J MGP_AJ_G0033471
protein coding gene Chr8:23053834-23137767 (+)
AKR/J MGP_AKRJ_G0033396
protein coding gene Chr8:23817639-23906770 (+)
BALB/cJ MGP_BALBcJ_G0033467
protein coding gene Chr8:23200432-23288047 (+)
C3H/HeJ MGP_C3HHeJ_G0033181
protein coding gene Chr8:24023709-24118549 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033983
protein coding gene Chr8:24890953-24993891 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030933
protein coding gene Chr8:20321718-20410703 (+)
CAST/EiJ MGP_CASTEiJ_G0032507
protein coding gene Chr8:23471598-23563727 (+)
CBA/J MGP_CBAJ_G0033156
protein coding gene Chr8:25867818-25963850 (+)
DBA/2J MGP_DBA2J_G0033311
protein coding gene Chr8:23023483-23107653 (+)
FVB/NJ MGP_FVBNJ_G0033255
protein coding gene Chr8:22829391-22918309 (+)
LP/J MGP_LPJ_G0033400
protein coding gene Chr8:23898121-23988864 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033298
protein coding gene Chr8:25320452-25421651 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034002
protein coding gene Chr8:23750876-23834851 (+)
PWK/PhJ MGP_PWKPhJ_G0032218
protein coding gene Chr8:22664463-22749423 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032052
protein coding gene Chr8:23125256-23222076 (+)
WSB/EiJ MGP_WSBEiJ_G0032623
protein coding gene Chr8:23968984-24056666 (+)



Homology
more
  • Human Ortholog
    KCNU1, potassium calcium-activated channel subfamily U member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KCNU1, potassium calcium-activated channel subfamily U member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KCa5, KCa5.1, Kcnma3, KCNMC1, Slo3
  • Links
    NCBI Gene ID: 157855
    neXtProt AC: NX_A8MYU2
    UniProt: A8MYU2

  • Chr Location
    8p11.23; chr8:36784324-36936125 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous male mutants are infertile with impaired sperm capacitation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031576 Ensembl Gene Model | MGI Sequence Detail 88317 C57BL/6J ±  kb
    transcript ENSMUST00000098858 Ensembl | MGI Sequence Detail 3536 Not Applicable  
    polypeptide ENSMUSP00000096457 Ensembl | MGI Sequence Detail 1121 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR005821 Ion transport domain
      IPR003929 Potassium channel, BK, alpha subunit
      IPR027359 Voltage-dependent channel domain superfamily
      IPR028325 Voltage-gated potassium channel
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:45626 Schreiber M, et al., Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. J Biol Chem. 1998 Feb 6;273(6):3509-16
    • Latest
      J:264928 Navarrete FA, et al., Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models. Sci Rep. 2016 Sep 15;6:33589

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory