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Cdk2ap1
Gene Detail
Symbol

Name
ID
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
MGI:1202069
Synonyms
Doc1, DORC1, p12, ST19
Feature Type
protein coding gene
Genetic Map
Chromosome 5
63.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:124345417-124354671 bp, - strand
From VEGA annotation of GRCm38

  9255 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDK2AP1
Protein SuperFamily: cyclin-dependent kinase 2-associated protein 2
Gene Tree: Cdk2ap1

Human
homologs
CDK2AP1, cyclin-dependent kinase 2 associated protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8099
neXtProt AC: NX_O14519

Human Synonyms: doc-1, DOC1, DORC1, p12DOC-1, ST19

Human Chr (Location): 12q24.31; chr12:123260970-123272316 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(82) : Gene trapped(80) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mic homozygous for a knock-out allele die between E3.5 and E5.5 with rare survivors exhibiting craniofacial defect.
 
Phenotype Images(1)
Interactions
Cdk2ap1 interacts with 98 markers (Mir17, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process face morphogenesis, in utero embryonic development, ...
Component nucleus, perinuclear region of cytoplasm
Function DNA polymerase binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (9)    Tissues (5)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 9
cDNA source data(122)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cdk2ap1    NEW 
Molecular
reagents
All nucleic(125) Genomic(1) cDNA(122) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024438 (Evidence)
Ensembl Gene Model ENSMUSG00000029394 (Evidence)
Entrez Gene 13445 (Evidence)
UniGene 425284
DFCI TC1573063
DoTS DT.97402140, DT.537933, DT.102545142
NIA Mouse Gene Index U112672, U062162
Consensus CDS Project CCDS39279.1
International Mouse Phenotyping Consortium Status Cdk2ap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024438 VEGA Gene Model | MGI Sequence Detail 9255 C57BL/6J ±  kb
transcript OTTMUST00000059921 VEGA | MGI Sequence Detail 1315 Not Applicable 
polypeptide OTTMUSP00000029189 VEGA | MGI Sequence Detail 114 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2)
Polymorphisms
SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000005254 cyclin-dependent kinase 2-associated protein 1
References
(Earliest) J:25193 Gordon HM, et al., Tumor necrosis factor induces genes involved in inflammation, cellular and tissue repair, and metabolism in murine fibroblasts. J Immunol. 1992 Jun 15;148(12):4021-7
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory