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Cdk2ap1 Gene Detail
Summary
  • Symbol
    Cdk2ap1
  • Name
    CDK2 (cyclin-dependent kinase 2)-associated protein 1
  • Synonyms
    Doc1, DORC1, p12, ST19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202069
    NCBI Gene: 13445
  • Gene Overview
    MyGene.info: CDK2AP1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:124345439-124354628 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 63.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202069
protein coding gene Chr5:124345417-124363082 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030093
protein coding gene Chr5:128149482-128171730 (-)
A/J MGP_AJ_G0030058
protein coding gene Chr5:122816803-122834997 (-)
AKR/J MGP_AKRJ_G0029994
protein coding gene Chr5:126769795-126792472 (-)
BALB/cJ MGP_BALBcJ_G0030069
protein coding gene Chr5:124151205-124170160 (-)
C3H/HeJ MGP_C3HHeJ_G0029786
protein coding gene Chr5:127382545-127397757 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030522
protein coding gene Chr5:133112811-133139109 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027748
protein coding gene Chr5:117345325-117354415 (-)
CAST/EiJ MGP_CASTEiJ_G0029195
protein coding gene Chr5:126499263-126508183 (-)
CBA/J MGP_CBAJ_G0029756
protein coding gene Chr5:138342846-138367798 (-)
DBA/2J MGP_DBA2J_G0029906
protein coding gene Chr5:122833965-122853313 (-)
FVB/NJ MGP_FVBNJ_G0029862
protein coding gene Chr5:121870237-121887425 (-)
LP/J MGP_LPJ_G0029995
protein coding gene Chr5:128697879-128716981 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029893
protein coding gene Chr5:141917652-141943103 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030563
protein coding gene Chr5:126385121-126407533 (-)
PWK/PhJ MGP_PWKPhJ_G0028909
protein coding gene Chr5:121654027-121663713 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028746
protein coding gene Chr5:124034020-124043914 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CDK2AP1, cyclin dependent kinase 2 associated protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDK2AP1, cyclin dependent kinase 2 associated protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    doc-1, DOC1, DORC1, p12DOC-1, ST19
  • Links
    NCBI Gene ID: 8099
    neXtProt AC: NX_O14519
    UniProt: O14519

  • Chr Location
    12q24.31; chr12:123260970-123272316 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mic homozygous for a knock-out allele die between E3.5 and E5.5 with rare survivors exhibiting craniofacial defect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13445 NCBI Gene Model | MGI Sequence Detail 9190 C57BL/6J ±  kb
    transcript NM_013812 RefSeq | MGI Sequence Detail 1283 Not Specified  
    polypeptide NP_038840 RefSeq | MGI Sequence Detail 114 Not Specified  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 127
      Genomic 1
      cDNA 124
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 13
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory