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Otog
Gene Detail
 Symbol
Name
ID
Otog
otogelin
MGI:1202064
Synonyms Otgn
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.66 cM, cytoband B4-C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:46240987-46311434 bp, + strand
From NCBI annotation of GRCm38

  70448 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8421  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: von Willebrand factor
Gene Tree: Otog

Human
homologs
Human Homolog OTOG, otogelin
NCBI Gene ID 340990
neXtProt AC  NX_Q6ZRI0
Human Synonyms  DFNB18B, MLEMP, OTGN
Human Chr (Location)  11p15.1; chr11:17547373-17645944 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human OTOG
Alleles
and
phenotypes
All alleles(12) : Spontaneous(5) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a number of different spontaneous and targeted mutations exhibit vestibular dysfunction, including circling, head tilt, impaired balance, coordination, and placing response. Mutants have impaired hearing, decreased brain stem auditory evoked potential, and ear abnormalities.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process adult locomotory behavior, blood coagulation, ...
Component cytosol, extracellular region, ...
Function alpha-L-arabinofuranosidase activity, structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (18)    Tissues (3)    Images (15)
Theiler Stages: 23
Assay TypeResults
RNA in situ 18
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(5) Genomic(1) cDNA(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000009487 (Evidence)
Entrez Gene18419 (Evidence)
UniGene8020
DFCITC1589117
DoTSDT.101706126, DT.87025056, DT.97363230
Consensus CDS ProjectCCDS52251.1
International Mouse Knockout Project StatusOtog
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18419 NCBI Gene Model | MGI Sequence Detail 70448 C57BL/6J ±  kb
transcript NM_013624 RefSeq | MGI Sequence Detail 10043 Not Specified 
polypeptide O55225 UniProt | EBI | MGI Sequence Detail 2910 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(981 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007934 Alpha-L-arabinofuranosidase B
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002919 Trypsin Inhibitor-like, cysteine rich domain
InterPro IPR014853 Uncharacterised domain, cysteine-rich
InterPro IPR012011 von Willebrand factor
InterPro IPR001007 von Willebrand factor, type C
InterPro IPR001846 von Willebrand factor, type D domain
Protein Ontology PR:000012073 otogelin
Graphical View of Protein Domain Structure
References (Earliest) J:13873 Lane PW, Twister (twt). Mouse News Lett. 1981;64:59
(Latest) J:196582 Romand R, et al., Retinoic acid deficiency impairs the vestibular function. J Neurosci. 2013 Mar 27;33(13):5856-66
All references(34)
Other
accession IDs
MGD-MRK-15306, MGI:98873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory