Otog
Gene Detail

Symbol Name ID

Otog otogelin MGI:1202064

Synonyms

Otgn

Feature Type

protein coding gene

Genetic Map

Chromosome 7

29.66 cM, cytoband B4-C
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:46240987-46311434 bp, + strand From NCBI annotation of GRCm38   70448 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8421  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: von Willebrand factor
Gene Tree: Otog

Human homologs

Human Homolog		OTOG, otogelin
NCBI Gene ID		340990
neXtProt AC		NX_Q6ZRI0
Human Synonyms		DFNB18B, MLEMP, OTGN
Human Chr (Location)		11p15.1; chr11:17568920-17667491 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human OTOG

Alleles and phenotypes

All alleles(12) : Targeted(7) Spontaneous(5)
 

Homozygotes for a number of different spontaneous and targeted mutations exhibit vestibular dysfunction, including circling, head tilt, impaired balance, coordination, and placing response. Mutants have impaired hearing, decreased brain stem auditory evoked potential, and ear abnormalities.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	adult locomotory behavior, blood coagulation, ...
Component	cytosol, extracellular region, ...
Function	alpha-N-arabinofuranosidase activity, structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (18)    Tissues (3)    Images (15)
Theiler Stages: 23

Assay Type	Results
RNA in situ	18

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) Genomic(1) cDNA(4)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000009487 (Evidence)
Entrez Gene	18419 (Evidence)
UniGene	8020
DFCI	TC1589117
DoTS	DT.101706126, DT.87025056, DT.97363230
Consensus CDS Project	CCDS52251.1
International Mouse Knockout Project Status	Otog

Sequences

Length	Strain/Species
genomic	18419	NCBI Gene Model | MGI Sequence Detail	70448	C57BL/6J
transcript	NM_013624	RefSeq | MGI Sequence Detail	10043	Not Specified
polypeptide	O55225	UniProt | EBI | MGI Sequence Detail	2910	Not Applicable

All sequences(15) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(635 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007934	Alpha-L-arabinofuranosidase B
InterPro	IPR006207	Cystine knot, C-terminal
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR002919	Trypsin Inhibitor-like, cysteine rich domain
InterPro	IPR014853	Uncharacterised domain, cysteine-rich
InterPro	IPR012011	von Willebrand factor
InterPro	IPR001007	von Willebrand factor, type C
InterPro	IPR001846	von Willebrand factor, type D domain
Protein Ontology	PR:000012073	otogelin

Graphical View of Protein Domain Structure

References

(Earliest) J:13873 Lane PW, Twister (twt). Mouse News Lett. 1981;64:59
(Latest) J:189624 Son EJ, et al., Developmental gene expression profiling along the tonotopic axis of the mouse cochlea. PLoS One. 2012;7(7):e40735
All references(33)

Other accession IDs

MGD-MRK-15306, MGI:98873