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Pde1a Gene Detail
Summary
  • Symbol
    Pde1a
  • Name
    phosphodiesterase 1A, calmodulin-dependent
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201792
    NCBI Gene: 18573
  • Gene Overview
    MyGene.info: PDE1A
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:79834453-80129458 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 47.64 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1864 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201792
protein coding gene Chr2:79834453-80196522 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025881
protein coding gene Chr2:80398111-80705789 (-)
A/J MGP_AJ_G0025858
protein coding gene Chr2:77295466-77589274 (-)
AKR/J MGP_AKRJ_G0025827
protein coding gene Chr2:79310808-79622020 (-)
BALB/cJ MGP_BALBcJ_G0025854
protein coding gene Chr2:77418505-77720034 (-)
C3H/HeJ MGP_C3HHeJ_G0025613
protein coding gene Chr2:79541254-79852279 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026300
protein coding gene Chr2:82770020-83087072 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023703
protein coding gene Chr2:74544056-74824655 (-)
CAST/EiJ MGP_CASTEiJ_G0025075
protein coding gene Chr2:79967542-80266600 (-)
CBA/J MGP_CBAJ_G0025594
protein coding gene Chr2:85738996-86069357 (-)
DBA/2J MGP_DBA2J_G0025725
protein coding gene Chr2:76839323-77129619 (-)
FVB/NJ MGP_FVBNJ_G0025687
protein coding gene Chr2:76209265-76489087 (-)
LP/J MGP_LPJ_G0025813
protein coding gene Chr2:80241883-80557745 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025718
protein coding gene Chr2:87602456-87945119 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026356
protein coding gene Chr2:79490488-79787777 (-)
PWK/PhJ MGP_PWKPhJ_G0024818
protein coding gene Chr2:76788267-77084386 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024624
protein coding gene Chr2:79765376-80045869 (-)
WSB/EiJ MGP_WSBEiJ_G0025144
protein coding gene Chr2:80108808-80406285 (-)



Homology
more
  • Human Ortholog
    PDE1A, phosphodiesterase 1A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDE1A, phosphodiesterase 1A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAM-PDE 1A, CAM-PDE-1A, HCAM1, HCAM-1, HSPDE1A
  • Links
    NCBI Gene ID: 5136
    neXtProt AC: NX_P54750
    UniProt: P54750

  • Chr Location
    2q32.1; chr2:182140035-182523375 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059173 Ensembl Gene Model | MGI Sequence Detail 295006 C57BL/6J ±  kb
transcript ENSMUST00000102655 Ensembl | MGI Sequence Detail 4258 Not Applicable  
polypeptide ENSMUSP00000099715 Ensembl | MGI Sequence Detail 545 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • EC
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR013706 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    IPR003607 HD/PDEase domain
Molecular
Reagents
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  • All nucleic 40
    cDNA 38
    Primer pair 1
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGI:2139118, MGI:2139319
References
more
  • Summaries
    All 45
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:37553 Yan C, et al., Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9677-81
  • Latest
    J:252096 Paul A, et al., Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity. Cell. 2017 Oct 19;171(3):522-539.e20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory