Socs3
Gene Detail

Symbol Name ID

Socs3 suppressor of cytokine signaling 3 MGI:1201791

Synonyms

CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

82.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:117966079-117970047 bp, - strand From VEGA annotation of GRCm38   3969 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2941  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: suppressor of cytokine signaling (SOCS) 1-3
Gene Tree: Socs3

Human homologs

Human Homolog		SOCS3, suppressor of cytokine signaling 3
NCBI Gene ID		9021
neXtProt AC		NX_O14543
Human Synonyms		ATOD4, CIS3, Cish3, SOCS-3, SSI3, SSI-3
Human Chr (Location)		17q25.3; chr17:76352859-76356158 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(17) : Targeted(8) Gene trapped(9)
 

Mice homozygous for mutations cause impairment if gene expression show immunological and hematopoetic abnormalities. Complete gene disruption causes lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	branching involved in labyrinthine layer morphogenesis, intracellular protein kinase cascade, ...
Component	cytoplasm
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (22)    Tissues (16)   
Theiler Stages: 10, 18, 20, 22, 23, 25, 28

Assay Type	Results
Northern blot	12
RT-PCR	10

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) cDNA(51) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000003735 (Evidence)
Ensembl Gene Model	ENSMUSG00000053113 (Evidence)
Entrez Gene	12702 (Evidence)
UniGene	3468
DFCI	TC1571892, TC1727860
DoTS	DT.101221192, DT.530948
NIA Mouse Gene Index	U033671
PDB	2BBU, 2HMH, 2JZ3
Consensus CDS Project	CCDS25697.1
International Mouse Knockout Project Status	Socs3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003735	VEGA Gene Model | MGI Sequence Detail	3969	C57BL/6J
transcript	OTTMUST00000008134	VEGA | MGI Sequence Detail	2552	Not Applicable
polypeptide	OTTMUSP00000003963	VEGA | MGI Sequence Detail	225	Not Applicable

All sequences(43) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000980	SH2 domain
InterPro	IPR001496	SOCS protein, C-terminal
Protein Ontology	PR:000015394	suppressor of cytokine signaling 3

References

(Earliest) J:42258 Minamoto S, et al., Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem Biophys Res Commun. 1997 Aug 8;237(1):79-83
(Latest) J:192314 Spence S, et al., Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization. Immunity. 2013 Jan 24;38(1):66-78
All references(147)