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Socs3
Gene Detail
Symbol

Name
ID
Socs3
suppressor of cytokine signaling 3
MGI:1201791
Synonyms
CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
82.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:117966079-117970047 bp, - strand
From VEGA annotation of GRCm38

  3969 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2941  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SOCS3
Protein SuperFamily: suppressor of cytokine signaling (SOCS) 1-3
Gene Tree: Socs3

Human
homologs
SOCS3, suppressor of cytokine signaling 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9021
neXtProt AC: NX_O14543

Human Synonyms: ATOD4, CIS3, Cish3, SOCS-3, SSI3, SSI-3

Human Chr (Location): 17q25.3; chr17:78356777-78360079 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(9) Targeted(8)
 
Mice homozygous for mutations cause impairment if gene expression show immunological and hematopoetic abnormalities. Complete gene disruption causes lethality.
 
Interactions
Socs3 interacts with 198 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (22)    Tissues (16)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
RT-PCR 10
cDNA source data(52)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase socs3 ; ZFIN socs3a, socs3b    NEW 
Molecular
reagents
All nucleic(53) cDNA(52) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000003735 (Evidence)
Ensembl Gene Model ENSMUSG00000053113 (Evidence)
Entrez Gene 12702 (Evidence)
UniGene 3468
DFCI TC1571892, TC1727860
DoTS DT.530948, DT.101221192
NIA Mouse Gene Index U033671
PDB 2HMH, 2BBU, 2JZ3, 4GL9
Consensus CDS Project CCDS25697.1
International Mouse Phenotyping Consortium Status Socs3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003735 VEGA Gene Model | MGI Sequence Detail 3969 C57BL/6J ±  kb
transcript OTTMUST00000008134 VEGA | MGI Sequence Detail 2552 Not Applicable 
polypeptide OTTMUSP00000003963 VEGA | MGI Sequence Detail 225 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
InterPro IPR001496 SOCS protein, C-terminal
Protein Ontology PR:000015394 suppressor of cytokine signaling 3
References
(Earliest) J:42258 Minamoto S, et al., Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem Biophys Res Commun. 1997 Aug 8;237(1):79-83
(Latest) J:220978 Zampieri TT, et al., SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes. Mol Metab. 2015 Mar;4(3):237-45
All references(169)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory