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Socs3
Gene Detail
 Symbol
Name
ID
Socs3
suppressor of cytokine signaling 3
MGI:1201791
Synonyms CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3
Feature Type protein coding gene
Genetic Map
Chromosome 11
82.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:117966079-117970047 bp, - strand
From VEGA annotation of GRCm38

  3969 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2941  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: suppressor of cytokine signaling (SOCS) 1-3
Gene Tree: Socs3

Human
homologs
Human Homolog SOCS3, suppressor of cytokine signaling 3
NCBI Gene ID 9021
neXtProt AC  NX_O14543
Human Synonyms  ATOD4, CIS3, Cish3, SOCS-3, SSI3, SSI-3
Human Chr (Location)  17q25.3; chr17:78356777-78360079 (-)  GRCh38
Alleles
and
phenotypes
All alleles(17) : Targeted(8) Gene trapped(9)
 
Mice homozygous for mutations cause impairment if gene expression show immunological and hematopoetic abnormalities. Complete gene disruption causes lethality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process branching involved in labyrinthine layer morphogenesis, intracellular signal transduction, ...
Component cytoplasm
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (22)    Tissues (16)   
Theiler Stages: 10, 18, 20, 22, 23, 25, 28
Assay TypeResults
Northern blot 12
RT-PCR 10
cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(53) cDNA(52) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000003735 (Evidence)
Ensembl Gene ModelENSMUSG00000053113 (Evidence)
Entrez Gene12702 (Evidence)
UniGene3468
DFCITC1571892, TC1727860
DoTSDT.101221192, DT.530948
NIA Mouse Gene IndexU033671
PDB2BBU, 2HMH, 2JZ3, 4GL9
Consensus CDS ProjectCCDS25697.1
International Mouse Knockout Project StatusSocs3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003735 VEGA Gene Model | MGI Sequence Detail 3969 C57BL/6J ±  kb
transcript OTTMUST00000008134 VEGA | MGI Sequence Detail 2552 Not Applicable 
polypeptide OTTMUSP00000003963 VEGA | MGI Sequence Detail 225 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
InterPro IPR001496 SOCS protein, C-terminal
Protein Ontology PR:000015394 suppressor of cytokine signaling 3
References (Earliest) J:42258 Minamoto S, et al., Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem Biophys Res Commun. 1997 Aug 8;237(1):79-83
(Latest) J:206300 Koike K, et al., Protective role of JAK/STAT signaling against renal fibrosis in mice with unilateral ureteral obstruction. Clin Immunol. 2014 Jan;150(1):78-87
All references(156)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory