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Oit1 Gene Detail
Summary
  • Symbol
    Oit1
  • Name
    oncoprotein induced transcript 1
  • Synonyms
    2310076N21Rik, EF-7, Fam3d
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201784
    NCBI Gene: 18300
  • Gene Overview
    MyGene.info: FAM3D
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:8348937-8378754 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 4.83 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    292 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201784
protein coding gene Chr14:8348937-8378763 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020993
protein coding gene Chr14:687225-719780 (-)
A/J MGP_AJ_G0020941
protein coding gene Chr14:661671-691103 (-)
AKR/J MGP_AKRJ_G0020918
protein coding gene Chr14:678774-707470 (-)
BALB/cJ MGP_BALBcJ_G0020943
protein coding gene Chr14:659541-689396 (-)
C3H/HeJ MGP_C3HHeJ_G0020728
protein coding gene Chr14:674620-704473 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021377
protein coding gene Chr14:709575-739817 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018946
protein coding gene Chr14:1571615-1600949 (-)
CAST/EiJ MGP_CASTEiJ_G0020250
protein coding gene Chr14:675080-707295 (-)
CBA/J MGP_CBAJ_G0020694
protein coding gene Chr14:725268-760920 (-)
DBA/2J MGP_DBA2J_G0020817
protein coding gene Chr14:639349-674608 (-)
FVB/NJ MGP_FVBNJ_G0020799
protein coding gene Chr14:644963-674270 (-)
LP/J MGP_LPJ_G0020894
protein coding gene Chr14:670265-705812 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020825
protein coding gene Chr14:700223-732214 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021410
protein coding gene Chr14:667097-695641 (-)
PWK/PhJ MGP_PWKPhJ_G0020002
protein coding gene Chr14:672543-703527 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019823
protein coding gene Chr14:689815-720512 (-)
WSB/EiJ MGP_WSBEiJ_G0020308
protein coding gene Chr14:679327-711256 (-)



Homology
more
  • Human Ortholog
    FAM3D, family with sequence similarity 3 member D
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FAM3D, family with sequence similarity 3 member D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EF7, OIT1
  • Links
    NCBI Gene ID: 131177
    neXtProt AC: NX_Q96BQ1
    UniProt: Q96BQ1

  • Chr Location
    3p14.2; chr3:58633943-58666843 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 16354
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FAM3D
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for a targeted mutation exhibit emotion/affect abnormalities including decreased anxiety and depression responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021749 Ensembl Gene Model | MGI Sequence Detail 29818 C57BL/6J ±  kb
transcript ENSMUST00000022269 Ensembl | MGI Sequence Detail 1253 Not Applicable  
polypeptide ENSMUSP00000022269 Ensembl | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 37

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145775, MGI:2444732
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:44165 Fu X, et al., E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
  • Latest
    J:241065 de Wit NJ, et al., Oit1/Fam3D, a gut-secreted protein displaying nutritional status-dependent regulation. J Nutr Biochem. 2012 Nov;23(11):1425-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory