Fam3d MGI Mouse Gene Detail - MGI:1201784 - FAM3 metabolism regulating signaling molecule D

Symbol

Fam3d
Name

FAM3 metabolism regulating signaling molecule D
Synonyms

2310076N21Rik, EF-7, Oit1

Feature Type

protein coding gene
IDs

MGI:1201784
NCBI Gene: 18300
Alliance

genome feature page
Transcription Start Sites

13 TSS

Sequence Map

Chr14:14091019-14120836 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 4.83 cM, cytoband A1
Mapping Data

3 experiments

SNPs within 2kb

1012 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1201784	protein coding gene	Chr14:14091010-14120836 (+)
129S1/SvImJ	ENSMUSG00200013259	protein coding gene	Chr14:10734604-10764842 (+)
A/J	ENSMUSG00195017522	protein coding gene	Chr14:11598822-11628641 (+)
AKR/J	ENSMUSG00220023797	protein coding gene	Chr14:10762786-10792608 (+)
BALB/cJ	ENSMUSG00180035783	protein coding gene	Chr14:10889628-10919445 (+)
C3H/HeJ	ENSMUSG00175023283	protein coding gene	Chr14:10957590-10988558 (+)
C57BL/6NJ	ENSMUSG00215029072	protein coding gene	Chr14:11138692-11168511 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018946	protein coding gene	Chr14:1571615-1600949 (-)
CAST/EiJ	ENSTCUG00005026517	protein coding gene	Chr14:10775680-10806473 (+)
CBA/J	ENSMUSG00210026505	protein coding gene	Chr14:11172642-11203611 (+)
DBA/2J	ENSMUSG00185036854	protein coding gene	Chr14:11181108-11212076 (+)
FVB/NJ	ENSMUSG00205031621	protein coding gene	Chr14:11093039-11124117 (+)
JF1/MsJ	ENSUMUG00000036365	protein coding gene	Chr14:11114088-11144294 (+)
LP/J	ENSMUSGG00230055734	protein coding gene	Chr14:12245220-12247579 (+)
NOD/ShiLtJ	ENSMUSG00190023606	protein coding gene	Chr14:11181268-11212342 (+)
NZO/HlLtJ	ENSMUSG00225035085	protein coding gene	Chr14:11540899-11571885 (+)
PWK/PhJ	ENSLUMG00010033257	protein coding gene	Chr14:32437320-32467536 (+)
SPRET/EiJ	ENSMSPG00010025068	protein coding gene	Chr14:11563627-11593308 (+)
WSB/EiJ	ENSIUOG00005030574	protein coding gene	Chr14:11019683-11049452 (+)

Human Ortholog

FAM3D, FAM3 metabolism regulating signaling molecule D

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM3D, FAM3 metabolism regulating signaling molecule D
Synonyms

EF7, OIT1
Links

HGNC:18665

NCBI Gene ID: 131177

UniProt: Q96BQ1
Chr Location

3p14.2; chr3:58633941-58666877 (-) GRCh38

MGI Vertebrate Homology

Fam3d stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FAM3D
Gene Tree

Fam3d

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Phenotype Summary

28 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

6
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a targeted mutation exhibit emotion/affect abnormalities including decreased anxiety and depression responses. Mice homozygous for a null allele exhibit colitis by 1 year of age, increased sensitivity to chemically-induced colitis associated with high incidence of cancer, abnormal gut flora balance and males show decreased development of induced abdominal aortic aneurysm.

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All GO Annotations

17
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

624
Tissues

15
cDNA Data

37
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

57
RefSeq

20
UniProt

2
CCDS

CCDS36802.1

Ensembl

ENSMUSG00000021749 (Evidence)
NCBI Gene

18300

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021749	Ensembl Gene Model \| MGI Sequence Detail	29818	C57BL/6J	± kb
transcript	ENSMUST00000022269	Ensembl \| MGI Sequence Detail	1253	Not Applicable
polypeptide	ENSMUSP00000022269	Ensembl \| MGI Sequence Detail	223	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031428 protein FAM3D

(term hierarchy)
InterPro Domains

IPR039475 FAM3C (ILEI) domain

IPR039220 FAM3 family

IPR039477 ILEI/PANDER domain
GlyGen

P97805 1 site

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All nucleic 37

cDNA 37

Microarray probesets 3

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MGI:2145775, MGI:2444732, MGI:6479867

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 11
Earliest

J:44165 Fu X, et al., E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
Latest

J:390347 Zhu S, et al., Targeting cytokine-like protein FAM3D alleviates atherosclerosis. Cell Rep Med. 2026 Jul 1;:102908

TSS for Fam3d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127436	Chr14:14090850-14090874 (+)	-157 bp
Tssr127435	Chr14:14090876-14090883 (+)	-139 bp
Tssr127434	Chr14:14090903-14090922 (+)	-106 bp
Tssr127433	Chr14:14090927-14090952 (+)	-79 bp
Tssr127432	Chr14:14090969-14091020 (+)	-24 bp
Tssr127431	Chr14:14091022-14091046 (+)	15 bp
Tssr127430	Chr14:14091068-14091073 (+)	52 bp
Tssr127429	Chr14:14101616-14101624 (+)	10,601 bp
Tssr127428	Chr14:14101637-14101653 (+)	10,626 bp
Tssr127427	Chr14:14102476-14102492 (+)	11,465 bp
Tssr127426	Chr14:14102493-14102512 (+)	11,484 bp
Tssr127425	Chr14:14102516-14102527 (+)	11,503 bp
Tssr127424	Chr14:14109411-14109434 (+)	18,404 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24