Oit3 MGI Mouse Gene Detail - MGI:1201782 - oncoprotein induced transcript 3

Oit3 Gene Detail

Symbol

Oit3
Name

oncoprotein induced transcript 3
Synonyms

EF-9

Feature Type

protein coding gene
IDs

MGI:1201782
NCBI Gene: 18302

Sequence Map

Chr10:59422958-59441778 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

18821 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 29.54 cM, cytoband B3
Mapping Data

2 experiments

Human Ortholog

OIT3, oncoprotein induced transcript 3

Vertebrate Orthologs

10

Human Ortholog

OIT3, oncoprotein induced transcript 3
Orthology source: HomoloGene, HGNC
Synonyms

LZP
Links

HGNC:29953

NCBI Gene ID: 170392

neXtProt AC: NX_Q8WWZ8
Chr Location

10q22.1; chr10:72893556-72933036 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 7870
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: OIT3
Protein SuperFamily

membrane glycoprotein 2
Gene Tree

Oit3

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Oit3
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for a knock-out allele exhibit decreased bloord uric acid, increased urine uric acid and polyuria.

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All GO Annotations

3
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

12
Tissues

12
cDNA Data

7
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase oit3

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Oit3 interacts with 152 markers (Mir1a-1, Mir1a-2, Mir19a, ...) View All

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All Sequences

22
RefSeq

2
UniProt

2
CCDS

CCDS23865.1
UniGene

123013

			Length	Strain/Species	Flank
genomic	OTTMUSG00000027943	VEGA Gene Model \| MGI Sequence Detail	18821	C57BL/6J	± kb
transcript	OTTMUST00000069221	VEGA \| MGI Sequence Detail	2717	Not Applicable
polypeptide	OTTMUSP00000035124	VEGA \| MGI Sequence Detail	546	Not Applicable

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SNPs within 2kb

128 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000011620 oncoprotein-induced transcript 3 protein
InterPro Domains

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR001507 Zona pellucida domain

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All nucleic 9

cDNA 7

Other 2

Microarray probesets 2

Summaries

All 23

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 12
Earliest

J:44165 Fu X, et al., E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
Latest

J:181913 Yan B, et al., OIT3 deficiency impairs uric acid reabsorption in renal tubule. FEBS Lett. 2012 Mar 23;586(6):760-5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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