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Oit3 Gene Detail
Summary
  • Symbol
    Oit3
  • Name
    oncoprotein induced transcript 3
  • Synonyms
    EF-9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201782
    NCBI Gene: 18302
Location & Maps
more
  • Sequence Map
    Chr10:59422958-59441778 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18821 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    OIT3, oncoprotein induced transcript 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OIT3, oncoprotein induced transcript 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LZP
  • Links
    NCBI Gene ID: 170392
    neXtProt AC: NX_Q8WWZ8

  • Chr Location
    10q22.1; chr10:72893556-72933036 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Oit3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased bloord uric acid, increased urine uric acid and polyuria.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027943 VEGA Gene Model | MGI Sequence Detail 18821 C57BL/6J ±  kb
transcript OTTMUST00000069221 VEGA | MGI Sequence Detail 2717 Not Applicable  
polypeptide OTTMUSP00000035124 VEGA | MGI Sequence Detail 546 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    128 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011620 oncoprotein-induced transcript 3 protein
  • InterPro Domains
    IPR000742 EGF-like domain
    IPR001507 Zona pellucida domain
Molecular
Reagents
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  • All nucleic 9
    cDNA 7
    Other 2

    Microarray probesets 2
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 12
  • Earliest
    J:44165 Fu X, et al., E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
  • Latest
    J:181913 Yan B, et al., OIT3 deficiency impairs uric acid reabsorption in renal tubule. FEBS Lett. 2012 Mar 23;586(6):760-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory