Oit3 MGI Mouse Gene Detail - MGI:1201782 - oncoprotein induced transcript 3

Symbol

Oit3
Name

oncoprotein induced transcript 3
Synonyms

EF-9

Feature Type

protein coding gene
IDs

MGI:1201782
NCBI Gene: 18302
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:59422960-59441779 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 29.54 cM, cytoband B3
Mapping Data

2 experiments

SNPs within 2kb

128 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1201782	protein coding gene	Chr10:59422958-59441779 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017257	protein coding gene	Chr10:58588385-58610203 (-)
A/J	MGP_AJ_G0017234	protein coding gene	Chr10:56877998-56896748 (-)
AKR/J	MGP_AKRJ_G0017193	protein coding gene	Chr10:58343417-58362516 (-)
BALB/cJ	MGP_BALBcJ_G0017195	protein coding gene	Chr10:56942709-56961279 (-)
C3H/HeJ	MGP_C3HHeJ_G0017018	protein coding gene	Chr10:58267624-58289282 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017653	protein coding gene	Chr10:60691465-60710711 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015344	protein coding gene	Chr10:53914184-53933429 (-)
CAST/EiJ	MGP_CASTEiJ_G0016589	protein coding gene	Chr10:58191589-58210866 (-)
CBA/J	MGP_CBAJ_G0016990	protein coding gene	Chr10:62871135-62889545 (-)
DBA/2J	MGP_DBA2J_G0017095	protein coding gene	Chr10:56187855-56207830 (-)
FVB/NJ	MGP_FVBNJ_G0017089	protein coding gene	Chr10:55423283-55441937 (-)
LP/J	MGP_LPJ_G0017170	protein coding gene	Chr10:58965147-58984472 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017117	protein coding gene	Chr10:65387345-65407629 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017690	protein coding gene	Chr10:58153525-58175517 (-)
PWK/PhJ	MGP_PWKPhJ_G0016372	protein coding gene	Chr10:55993788-56012930 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016155	protein coding gene	Chr10:57501450-57521765 (-)
WSB/EiJ	MGP_WSBEiJ_G0016653	protein coding gene	Chr10:58055127-58075797 (-)

Human Ortholog

OIT3, oncoprotein induced transcript 3

Vertebrate Orthologs

10

Human Ortholog

OIT3, oncoprotein induced transcript 3
Orthology source: HomoloGene, HGNC
Synonyms

LZP
Links

HGNC:29953

NCBI Gene ID: 170392

neXtProt AC: NX_Q8WWZ8

UniProt: Q8WWZ8
Chr Location

10q22.1; chr10:72893556-72933036 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7870
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: OIT3
Protein SuperFamily

membrane glycoprotein 2
Gene Tree

Oit3

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Oit3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased bloord uric acid, increased urine uric acid and polyuria.

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All GO Annotations

3
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

12
Tissues

12
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase oit3

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Oit3 interacts with 152 markers (Mir1a-1, Mir1a-2, Mir19a, ...) View All

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS23865.1
UniGene

123013

Ensembl

ENSMUSG00000009654 (Evidence)
NCBI Gene

18302

			Length	Strain/Species	Flank
genomic	18302	NCBI Gene Model \| MGI Sequence Detail	18820	C57BL/6J	± kb
transcript	NM_010959	RefSeq \| MGI Sequence Detail	2716	C57BL/6
polypeptide	Q8R4V5	UniProt \| EBI \| MGI Sequence Detail	546	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011620 oncoprotein-induced transcript 3 protein

(term hierarchy)
InterPro Domains

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR001507 Zona pellucida domain

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All nucleic 8

cDNA 8

Microarray probesets 2

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:181913 Yan B, et al., OIT3 deficiency impairs uric acid reabsorption in renal tubule. FEBS Lett. 2012 Mar 23;586(6):760-5

TSS for Oit3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97659	Chr10:59441869-59441880 (-)	-96 bp
Tssr97658	Chr10:59441840-59441851 (-)	-67 bp
Tssr97657	Chr10:59441838-59441839 (-)	-60 bp
Tssr97656	Chr10:59441801-59441808 (-)	-26 bp
Tssr97655	Chr10:59441784-59441800 (-)	-13 bp
Tssr97654	Chr10:59441748-59441782 (-)	14 bp
Tssr97653	Chr10:59441708-59441713 (-)	68 bp
Tssr97652	Chr10:59438910-59438913 (-)	2,867 bp
Tssr97651	Chr10:59430999-59431038 (-)	10,760 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14