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Atp6v1a Gene Detail
Summary
  • Symbol
    Atp6v1a
  • Name
    ATPase, H+ transporting, lysosomal V1 subunit A
  • Synonyms
    Atp6a1, lysosomal 70kDa, VA68, VPP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201780
    NCBI Gene: 11964
  • Gene Overview
    MyGene.info: ATP6V1A
Location & Maps
more
  • Sequence Map
    Chr16:44085402-44139705 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      54304 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 28.44 cM, cytoband B4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ATP6V1A, ATPase H+ transporting V1 subunit A
  • Vertebrate Orthologs
    12
  • Human Ortholog
    ATP6V1A, ATPase H+ transporting V1 subunit A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATP6A1, ATP6V1A1, HO68, VA68, Vma1, VPP2
  • Links
    NCBI Gene ID: 523
    neXtProt AC: NX_P38606

  • Chr Location
    3q13.31; chr3:113747019-113812058 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    29
  • Gene trapped
    25
  • Targeted
    4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023485 VEGA Gene Model | MGI Sequence Detail 54304 C57BL/6J ±  kb
transcript OTTMUST00000057143 VEGA | MGI Sequence Detail 4234 Not Applicable  
polypeptide OTTMUSP00000027535 VEGA | MGI Sequence Detail 617 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    186 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004480 V-type proton ATPase catalytic subunit A
  • EC
  • InterPro Domains
    IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site
    IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain
    IPR024034 ATPase, F1 complex beta subunit/V1 complex, C-terminal
    IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal
    IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
    IPR005725 ATPase, V1 complex, subunit A
    IPR031686 ATPsynthase alpha/beta subunit, N-terminal extension
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR022878 V-type ATP synthase catalytic alpha chain
Molecular
Reagents
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  • All nucleic 346
    cDNA 345
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2146472
References
more
  • Summaries
    All 41
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:31176 Laitala-Leinonen T, et al., Resorption-cycle-dependent polarization of mRNAs for different subunits of V-ATPase in bone-resorbing osteoclasts. Mol Biol Cell. 1996 Jan;7(1):129-42
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory