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Ctbp2
Gene Detail
 Symbol
Name
ID
Ctbp2
C-terminal binding protein 2
MGI:1201686
Synonyms D7Ertd45e, Gtrgeo6, Ribeye
Feature Type protein coding gene
Genetic Map
Chromosome 7
76.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:132987563-133124354 bp, - strand
From VEGA annotation of GRCm38

  136792 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: phosphoglycerate dehydrogenase
Gene Tree: Ctbp2

Human
homologs
Human Homolog CTBP2, C-terminal binding protein 2
NCBI Gene ID 1488
neXtProt AC  NX_P56545
Human Chr (Location)  10q26.13; chr10:124987849-125161055 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a gene-trapped allele die by E10 exhibiting a small size, axial truncations, a thin neural epithelium, a dilated pericardium, delayed fore- and midbrain development, and defects in heart morphogenesis, placental development and extraembryonic vascularization.
 
Interactions
Ctbp2 interacts with 370 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell differentiation, metabolic process, ...
Component cell junction, nucleus, ...
Function NAD binding, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (141)    Tissues (38)    Images (23)
Theiler Stages: 15, 17, 19, 20, 23, 28
Assay TypeResults
RNA in situ 131
Northern blot 10
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036726 (Evidence)
Ensembl Gene ModelENSMUSG00000030970 (Evidence)
Entrez Gene13017 (Evidence)
Consensus CDS ProjectCCDS21930.1, CCDS52417.1
International Mouse Knockout Project StatusCtbp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036726 VEGA Gene Model | MGI Sequence Detail 136792 C57BL/6J ±  kb
transcript OTTMUST00000094151 VEGA | MGI Sequence Detail 3604 Not Applicable 
polypeptide OTTMUSP00000052304 VEGA | MGI Sequence Detail 988 Not Applicable 

For the selected sequences
All sequences(144) RefSeq(20) UniProt(15)
Polymorphisms SNPs within 2kb(1002 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
InterPro IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000005995 C-terminal-binding protein 2
References (Earliest) J:40477 Baker RK, et al., In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(77)
Other
accession IDs
MGI:1098619, MGI:2141805, MGI:894664

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory