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Eomes Gene Detail
Summary
  • Symbol
    Eomes
  • Name
    eomesodermin
  • Synonyms
    Tbr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201683
    NCBI Gene: 13813
  • Gene Overview
    MyGene.info: EOMES
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:118478212-118486132 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 70.21 cM, cytoband F3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201683
protein coding gene Chr9:118478189-118486132 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035405
protein coding gene Chr9:121157863-121165779 (+)
A/J MGP_AJ_G0035385
protein coding gene Chr9:116682120-116690043 (+)
AKR/J MGP_AKRJ_G0035318
protein coding gene Chr9:119693419-119701332 (+)
BALB/cJ MGP_BALBcJ_G0035381
protein coding gene Chr9:116546916-116554838 (+)
C3H/HeJ MGP_C3HHeJ_G0035089
protein coding gene Chr9:120173642-120181565 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035904
protein coding gene Chr9:124468157-124476074 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032787
protein coding gene Chr9:113888127-113896129 (+)
CAST/EiJ MGP_CASTEiJ_G0034393
protein coding gene Chr9:120123868-120131792 (+)
CBA/J MGP_CBAJ_G0035056
protein coding gene Chr9:129144606-129152526 (+)
DBA/2J MGP_DBA2J_G0035215
protein coding gene Chr9:116126565-116134505 (+)
FVB/NJ MGP_FVBNJ_G0035162
protein coding gene Chr9:114962179-114970102 (+)
LP/J MGP_LPJ_G0035294
protein coding gene Chr9:121505788-121513701 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035203
protein coding gene Chr9:130189837-130197760 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035923
protein coding gene Chr9:120078775-120086692 (+)
PWK/PhJ MGP_PWKPhJ_G0034100
protein coding gene Chr9:116505943-116514290 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033934
protein coding gene Chr9:120165822-120173708 (+)
WSB/EiJ MGP_WSBEiJ_G0034514
protein coding gene Chr9:119976130-119984041 (+)



Homology
more
  • Human Ortholog
    EOMES, eomesodermin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EOMES, eomesodermin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TBR2
  • Links
    NCBI Gene ID: 8320
    neXtProt AC: NX_O95936
    UniProt: O95936

  • Chr Location
    3p24.1; chr3:27715949-27722715 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 11 alleles in 12 genetic backgrounds
    37 phenotypes from multigenic genotypes
    1 images
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality, fail to implant, and lack trophoectoderm outgrowth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032446 Ensembl Gene Model | MGI Sequence Detail 7921 C57BL/6J ±  kb
    transcript ENSMUST00000035020 Ensembl | MGI Sequence Detail 3560 Not Applicable  
    polypeptide ENSMUSP00000035020 Ensembl | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      Genomic 2
      cDNA 47
      Primer pair 11
      Other 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1313283, MGI:2143384
    References
    more
    • Summaries
      All 662
      Developmental Gene Expression 546
      Gene Ontology 24
      Phenotypes 76
    • Earliest
      J:46272 Wattler S, et al., A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family. Genomics. 1998 Feb 15;48(1):24-33
    • Latest
      J:266242 Desmaris E, et al., DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors. J Neurosci. 2018 Oct 17;38(42):9105-9121

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory