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Eomes
Gene Detail
Symbol

Name
ID
Eomes
eomesodermin homolog (Xenopus laevis)
MGI:1201683
Synonyms
Tbr2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
70.21 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:118478212-118486132 bp, + strand
From VEGA annotation of GRCm38

  7921 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3971  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EOMES
Gene Tree: Eomes

Human
homologs
EOMES, eomesodermin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8320
neXtProt AC: NX_O95936

Human Synonyms: TBR2

Human Chr (Location): 3p24.1; chr3:27715949-27722715 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality, fail to implant, and lack trophoectoderm outgrowth.
 
Interactions
Eomes interacts with 206 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process adaptive immune response, blastocyst development, ...
Component intracellular, nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (369 records)
Data Summary: Results (644)    Tissues (246)    Images (207)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 151
RNA in situ 363
In situ reporter (knock in) 31
Northern blot 5
Western blot 4
RT-PCR 90
cDNA source data(40)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA EOMES ; Xenbase eomes ; ZFIN eomesa, eomesb    NEW 
Molecular
reagents
All nucleic(60) Genomic(2) cDNA(44) Primer pair(10) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021058 (Evidence)
Ensembl Gene Model ENSMUSG00000032446 (Evidence)
Entrez Gene 13813 (Evidence)
UniGene 200692
DFCI TC1581871, TC1594770, TC1642071, TC1643213, TC1667767, TC1747094
DoTS DT.101167283, DT.488186, DT.91330474, DT.97349426, DT.97386218
Consensus CDS Project CCDS23603.1, CCDS52960.1
International Mouse Phenotyping Consortium Status Eomes
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021058 VEGA Gene Model | MGI Sequence Detail 7921 C57BL/6J ±  kb
transcript OTTMUST00000049812 VEGA | MGI Sequence Detail 3560 Not Applicable 
polypeptide OTTMUSP00000023138 VEGA | MGI Sequence Detail 707 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000003463 eomesodermin
References
(Earliest) J:46272 Wattler S, et al., A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family. Genomics. 1998 Feb 15;48(1):24-33
(Latest) J:222255 Knock E, et al., The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex. Neural Dev. 2015;10:13
All references(437)
Other
accession IDs
MGI:1313283, MGI:2143384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory