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Eomes
Gene Detail
Symbol

Name
ID
Eomes
eomesodermin homolog (Xenopus laevis)
MGI:1201683
Synonyms
Tbr2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
70.21 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:118478212-118486132 bp, + strand
From VEGA annotation of GRCm38

  7921 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3971  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Eomes

Human
homologs
Human Homolog EOMES, eomesodermin
NCBI Gene ID 8320
neXtProt AC  NX_O95936
Human Synonyms  TBR2
Human Chr (Location)  3p24.1; chr3:27715949-27722715 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Targeted(14)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality, fail to implant, and lack trophoectoderm outgrowth.
 
Interactions
Eomes interacts with 207 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process blastocyst development, brain development, ...
Component intracellular, nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (331 records)
Data Summary: Results (595)    Tissues (229)    Images (174)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 133
RNA in situ 363
Northern blot 5
Western blot 4
RT-PCR 90
cDNA source data(40)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(60) Genomic(2) cDNA(44) Primer pair(10) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021058 (Evidence)
Ensembl Gene ModelENSMUSG00000032446 (Evidence)
Entrez Gene13813 (Evidence)
UniGene200692
DFCITC1581871, TC1642071, TC1747094, TC1594770, TC1667767, TC1643213
DoTSDT.97349426, DT.97386218, DT.91330474, DT.488186, DT.101167283
Consensus CDS ProjectCCDS23603.1, CCDS52960.1
International Mouse Knockout Project StatusEomes
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021058 VEGA Gene Model | MGI Sequence Detail 7921 C57BL/6J ±  kb
transcript OTTMUST00000049812 VEGA | MGI Sequence Detail 3560 Not Applicable 
polypeptide OTTMUSP00000023138 VEGA | MGI Sequence Detail 707 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(5)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000003463 eomesodermin
References
(Earliest) J:46272 Wattler S, et al., A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family. Genomics. 1998 Feb 15;48(1):24-33
(Latest) J:214315 Yamada M, et al., MLLT11/AF1q is differentially expressed in maturing neurons during development. Gene Expr Patterns. 2014 Jul;15(2):80-7
All references(396)
Other
accession IDs
MGI:1313283, MGI:2143384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory