About   Help   FAQ
Cacna1g
Gene Detail
Symbol

Name
ID
Cacna1g
calcium channel, voltage-dependent, T type, alpha 1G subunit
MGI:1201678
Synonyms
a1G, Cav3.1d, mKIAA1123
Feature Type
protein coding gene
Genetic Map
Chromosome 11
58.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:94408391-94474100 bp, - strand
From VEGA annotation of GRCm38

  65710 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cacna1g

Human
homologs
Human Homolog CACNA1G, calcium channel, voltage-dependent, T type, alpha 1G subunit
NCBI Gene ID 8913
neXtProt AC  NX_O43497
Human Synonyms  Cav3.1, Ca(V)T.1, NBR13
Human Chr (Location)  17q22; chr17:50561068-50629625 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Genomic Mutations involving Cacna1g (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygote null mice display disrupted sleeping patterns, altered amounts of activity, abnormal action potentials in the brain, prolonged electrical conductance in the heart, and resistance to diet-induced obesity.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Cacna1g interacts with 253 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process action potential, artery smooth muscle contraction, ...
Component cell body, cytosol, ...
Function low voltage-gated calcium channel activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (78)    Tissues (53)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 40
RT-PCR 36
cDNA source data(58)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) cDNA(58) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001890 (Evidence)
Ensembl Gene ModelENSMUSG00000020866 (Evidence)
Entrez Gene12291 (Evidence)
UniGene29585
DFCITC1578646, TC1586305, TC1599069, TC1596991, TC1676200, TC1677573
DoTSDT.101157263, DT.91339494, DT.40166535, DT.101328144, DT.110502361, DT.94344056
NIA Mouse Gene IndexU033279
Consensus CDS ProjectCCDS25255.1, CCDS48884.1, CCDS48885.1, CCDS48886.1
International Mouse Knockout Project StatusCacna1g
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001890 VEGA Gene Model | MGI Sequence Detail 65710 C57BL/6J ±  kb
transcript OTTMUST00000003940 VEGA | MGI Sequence Detail 8383 Not Applicable 
polypeptide OTTMUSP00000001911 VEGA | MGI Sequence Detail 2381 Not Applicable 

For the selected sequences
All sequences(173) RefSeq(57) UniProt(34)
Polymorphisms
RFLP(1) : SNPs within 2kb(478 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
InterPro IPR005445 Voltage-dependent calcium channel, T-type, alpha-1 subunit
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000001972 voltage-dependent T-type calcium channel subunit alpha-1G
References
(Earliest) J:46135 Perez-Reyes E, et al., Molecular characterization of a neuronal low-voltage-activated T-type calcium channel [see comments]. Nature. 1998 Feb 26;391(6670):896-900
(Latest) J:213554 Thuesen AD, et al., Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo. Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F445-52
All references(70)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory