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Cacna1g Gene Detail
Summary
  • Symbol
    Cacna1g
  • Name
    calcium channel, voltage-dependent, T type, alpha 1G subunit
  • Synonyms
    a1G, Cav3.1d, mKIAA1123
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201678
    NCBI Gene: 12291
  • Gene Overview
    MyGene.info: CACNA1G
Location & Maps
more
  • Sequence Map
    Chr11:94408391-94474100 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65710 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 58.90 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CACNA1G, calcium voltage-gated channel subunit alpha1 G
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CACNA1G, calcium voltage-gated channel subunit alpha1 G
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Cav3.1, Ca(V)T.1, NBR13, SCA42
  • Links
    NCBI Gene ID: 8913
    neXtProt AC: NX_O43497

  • Chr Location
    17q22; chr17:50561068-50629625 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 5 alleles in 6 genetic backgrounds
    9 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Targeted
    10
  • Transgenic
    3
  • Genomic Mutations
    3 involving Cacna1g
  • Incidental Mutations
Homozygote null mice display disrupted sleeping patterns, altered amounts of activity, abnormal action potentials in the brain, prolonged electrical conductance in the heart, and resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001890 VEGA Gene Model | MGI Sequence Detail 65710 C57BL/6J ±  kb
transcript OTTMUST00000003940 VEGA | MGI Sequence Detail 8383 Not Applicable  
polypeptide OTTMUSP00000001911 VEGA | MGI Sequence Detail 2381 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    475 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    17 Sequences
  • InterPro Domains
    IPR005821 Ion transport domain
    IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
    IPR030154 Voltage-dependent calcium channel,T-type, alpha-1G subunit
    IPR005445 Voltage-dependent calcium channel, T-type, alpha-1 subunit
    IPR027359 Voltage-dependent channel, four helix bundle domain
Molecular
Reagents
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  • All nucleic 66
    cDNA 58
    Primer pair 7
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 67
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 8
    Phenotypes 37
  • Earliest
    J:46135 Perez-Reyes E, et al., Molecular characterization of a neuronal low-voltage-activated T-type calcium channel [see comments]. Nature. 1998 Feb 26;391(6670):896-900
  • Latest
    J:230133 Chevalier M, et al., T-type calcium channels are involved in hypoxic pulmonary hypertension. Cardiovasc Res. 2014 Sep 1;103(4):597-606

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory