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Psmd4 Gene Detail
Summary
  • Symbol
    Psmd4
  • Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
  • Synonyms
    Af1, angiocidin, Mcb1, multiubiquitin-chain-binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201670
    NCBI Gene: 19185
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:94939999-94949880 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201670
 protein coding gene Chr3:94939999-94949925 (-)
129S1/SvImJ ENSMUSG00200041990
 protein coding gene Chr3:91596942-91606865 (-)
A/J ENSMUSG00195045540
 protein coding gene Chr3:91922462-91932379 (-)
AKR/J ENSMUSG00220048106
 protein coding gene Chr3:90309436-90319360 (-)
BALB/cJ ENSMUSG00180036562
 protein coding gene Chr3:91922109-91932037 (-)
C3H/HeJ ENSMUSG00175023355
 protein coding gene Chr3:91566161-91576076 (-)
C57BL/6NJ ENSMUSG00215024725
 protein coding gene Chr3:92284475-92294397 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025324
 protein coding gene Chr3:89130710-89140627 (-)
CAST/EiJ ENSTCUG00005044547
 protein coding gene Chr3:92126586-92136372 (-)
CBA/J ENSMUSG00210050542
 protein coding gene Chr3:92103639-92113554 (-)
DBA/2J ENSMUSG00185037675
 protein coding gene Chr3:92520217-92530130 (-)
FVB/NJ ENSMUSG00205047158
 protein coding gene Chr3:91219872-91229804 (-)
JF1/MsJ ENSUMUG00000040277
 protein coding gene Chr3:91421745-91431904 (-)
LP/J ENSMUSG00230042074
 protein coding gene Chr3:94460453-94470372 (-)
NOD/ShiLtJ ENSMUSG00190032503
 protein coding gene Chr3:92613530-92623453 (-)
NZO/HlLtJ ENSMUSG00225010699
 protein coding gene Chr3:96883660-96893583 (-)
PWK/PhJ ENSLUMG00010049471
 protein coding gene Chr3:91401737-91411920 (-)
SPRET/EiJ ENSMSPG00010044735
 protein coding gene Chr3:91707300-91717102 (-)
WSB/EiJ ENSIUOG00005028512
 protein coding gene Chr3:92042506-92052424 (-)



Homology
more
  • Human Ortholog
    PSMD4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMD4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4
  • Synonyms
    AF, AF-1, ASF, MCB1, pUB-R5, Rpn10, S5A
  • Links
    NCBI Gene ID: 5710
    UniProt: P55036

  • Chr Location
    1q21.3; chr1:151254709-151267479 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality and abnormal embryogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    22
  • cDNA Data
    10
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19185 NCBI Gene Model | MGI Sequence Detail 9882 C57BL/6J ±  kb
transcript NM_001282017 RefSeq | MGI Sequence Detail 1286 ZRU/MplStud  
polypeptide O35226 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000002181 26S proteasome non-ATPase regulatory subunit 4
    (term hierarchy)
  • InterPro Domains
    IPR027040 26S proteasome non-ATPase regulatory subunit 4
    IPR049590 PSMD4, RAZUL domain
    IPR003903 Ubiquitin interacting motif
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
  • GlyGen
    O35226 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 2
    Antibodies 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36380, MGI:107803
References
more
  • Summaries
    All 55
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:367356 Yue WY, et al., Non-Redundant Essential Roles of Proteasomal Ubiquitin Receptors Rpn10 and Rpn13 in Germ Cell Formation and Fertility. Cells. 2025 May 12;14(10)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory