Mfsd14a MGI Mouse Gene Detail - MGI:1201609 - major facilitator superfamily domain containing 14A

Mfsd14a Gene Detail

Symbol

Mfsd14a
Name

major facilitator superfamily domain containing 14A
Synonyms

Hiat1

Feature Type

protein coding gene
IDs

MGI:1201609
NCBI Gene: 15247

Sequence Map

Chr3:116631164-116662677 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

31514 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 50.42 cM, cytoband G2
Mapping Data

2 experiments

Human Ortholog

MFSD14A, major facilitator superfamily domain containing 14A

Vertebrate Orthologs

10

Human Ortholog

MFSD14A, major facilitator superfamily domain containing 14A
Orthology source: HomoloGene, HGNC
Synonyms

HIAT1
Links

HGNC:23363

NCBI Gene ID: 64645

neXtProt AC: NX_Q96MC6

UniProt: Q96MC6
Chr Location

1p21.2; chr1:100038078-100083377 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 22456
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: MFSD14A
Gene Tree

Mfsd14a

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References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Gene trapped

7
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Mfsd14a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

78 strains or lines available

Mice homozygous for a knock-out allele exhibit male infertility with oligozoospermia, globozoospermia, and defects in spermiogenesis and acrosome formation.

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All GO Annotations

6
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

17
Tissues

15
cDNA Data

12
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Mfsd14a interacts with 320 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

35
RefSeq

8
UniProt

1
CCDS

CCDS17790.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000029518	VEGA Gene Model \| MGI Sequence Detail	31514	C57BL/6J	± kb
transcript	OTTMUST00000073141	VEGA \| MGI Sequence Detail	2782	Not Applicable
polypeptide	OTTMUSP00000037831	VEGA \| MGI Sequence Detail	490	Not Applicable

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SNPs within 2kb

191 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000008546 hippocampus abundant transcript 1 protein

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR005829 Sugar transporter, conserved site

IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG

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All nucleic 12

cDNA 12

Microarray probesets 4

Summaries

All 32

Developmental Gene Expression 1

Diseases 1

Gene Ontology 3

Phenotypes 9
Earliest

J:42916 Matsuo N, et al., Cloning of a cDNA encoding a novel sugar transporter expressed in the neonatal mouse hippocampus. Biochem Biophys Res Commun. 1997 Sep 8;238(1):126-9
Latest

J:230570 Doran J, et al., Mfsd14a (Hiat1) gene disruption causes globozoospermia and infertility in male mice. Reproduction. 2016 Apr 22;

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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