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Mfsd14a Gene Detail
Summary
  • Symbol
    Mfsd14a
  • Name
    major facilitator superfamily domain containing 14A
  • Synonyms
    Hiat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201609
    NCBI Gene: 15247
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:116631164-116662677 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 50.42 cM, cytoband G2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201609
 protein coding gene Chr3:116631164-116662692 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027815
 protein coding gene Chr3:118540851-118572142 (-)
A/J MGP_AJ_G0027773
 protein coding gene Chr3:114659935-114691572 (-)
AKR/J MGP_AKRJ_G0027739
 protein coding gene Chr3:117566755-117598276 (-)
BALB/cJ MGP_BALBcJ_G0027785
 protein coding gene Chr3:114501968-114533550 (-)
C3H/HeJ MGP_C3HHeJ_G0027516
 protein coding gene Chr3:117924580-117957510 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028231
 protein coding gene Chr3:122889533-122921026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025570
 protein coding gene Chr3:110348876-110378850 (-)
CAST/EiJ MGP_CASTEiJ_G0026972
 protein coding gene Chr3:117210506-117242194 (-)
CBA/J MGP_CBAJ_G0027491
 protein coding gene Chr3:127081067-127115231 (-)
DBA/2J MGP_DBA2J_G0027632
 protein coding gene Chr3:113897705-113929037 (-)
FVB/NJ MGP_FVBNJ_G0027600
 protein coding gene Chr3:111534615-111565807 (-)
LP/J MGP_LPJ_G0027742
 protein coding gene Chr3:120082849-120116177 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027630
 protein coding gene Chr3:134466201-134499074 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028287
 protein coding gene Chr3:117101278-117134071 (-)
PWK/PhJ MGP_PWKPhJ_G0026698
 protein coding gene Chr3:113542582-113574375 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026520
 protein coding gene Chr3:115110999-115148629 (-)
WSB/EiJ MGP_WSBEiJ_G0027052
 protein coding gene Chr3:117784568-117816116 (-)



Homology
more
  • Human Ortholog
    MFSD14A, major facilitator superfamily domain containing 14A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MFSD14A, major facilitator superfamily domain containing 14A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HIAT1
  • Links
    NCBI Gene ID: 64645
    neXtProt AC: NX_Q96MC6
    UniProt: Q96MC6

  • Chr Location
    1p21.2; chr1:100038078-100083377 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility with oligozoospermia, globozoospermia, and defects in spermiogenesis and acrosome formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    17
  • Tissues
    15
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000089911 Ensembl Gene Model | MGI Sequence Detail 31514 C57BL/6J ±  kb
    transcript ENSMUST00000029570 Ensembl | MGI Sequence Detail 2782 Not Applicable  
    polypeptide ENSMUSP00000029570 Ensembl | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008546 hippocampus abundant transcript 1 protein
      (term hierarchy)
    • InterPro Domains
      IPR011701 Major facilitator superfamily
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR005829 Sugar transporter, conserved site
      IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 4
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 2
      Phenotypes 9
    • Earliest
      J:42916 Matsuo N, et al., Cloning of a cDNA encoding a novel sugar transporter expressed in the neonatal mouse hippocampus. Biochem Biophys Res Commun. 1997 Sep 8;238(1):126-9
    • Latest
      J:230570 Doran J, et al., Mfsd14a (Hiat1) gene disruption causes globozoospermia and infertility in male mice. Reproduction. 2016 Jul;152(1):91-9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/06/2018
    MGI 6.13     		The Jackson Laboratory