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Hrk
Gene Detail
 Symbol
Name
ID
Hrk
harakiri, BCL2 interacting protein (contains only BH3 domain)
MGI:1201608
Synonyms Bid3, DP5
Feature Type protein coding gene
Genetic Map
Chromosome 5
58.16 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:118164648-118189478 bp, + strand
From VEGA annotation of GRCm38

  24831 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137206  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: activator of apoptosis harakiri
Gene Tree: Hrk

Alleles
and
phenotypes
All alleles(4) : Gene trapped(2) Targeted(2)
 
Homozygous mutants exhibit motoneurons that are protected from cell death induced by resection of the hypoglossal nerve and delayed cell death of superior cervical ganglia neurons triggered by nerve growth factor withdrawal.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process apoptotic process, cellular response to potassium ion starvation, ...
Component integral component of membrane, membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (29)    Tissues (21)   
Theiler Stages: 20, 21, 22, 28
Assay TypeResults
RNA in situ 18
Northern blot 10
RT-PCR 1
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000044796 (Evidence)
Ensembl Gene ModelENSMUSG00000046607 (Evidence)
Entrez Gene12123 (Evidence)
UniGene384468
DFCITC1591042, TC1647102
DoTSDT.40185360
NIA Mouse Gene IndexU042682
Consensus CDS ProjectCCDS39236.1
International Mouse Knockout Project StatusHrk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044796 VEGA Gene Model | MGI Sequence Detail 24831 C57BL/6J ±  kb
transcript OTTMUST00000117740 VEGA | MGI Sequence Detail 5382 Not Applicable 
polypeptide OTTMUSP00000065787 VEGA | MGI Sequence Detail 92 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017249 Activator of apoptosis harakiri
InterPro IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
Protein Ontology PR:000008752 activator of apoptosis harakiri
References (Earliest) J:41987 Imaizumi K, et al., Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death. J Biol Chem. 1997 Jul 25;272(30):18842-8
(Latest) J:210416 Fernandes KA, et al., JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells. Exp Eye Res. 2013 Jul;112:106-17
All references(38)
Other
accession IDs
MGI:2140973

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory