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Hrk Gene Detail
Summary
  • Symbol
    Hrk
  • Name
    harakiri, BCL2 interacting protein (contains only BH3 domain)
  • Synonyms
    Bid3, DP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201608
    NCBI Gene: 12123
  • Gene Overview
    MyGene.info: HRK
Location & Maps
more
  • Sequence Map
    Chr5:118164648-118189478 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24831 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HRK, harakiri, BCL2 interacting protein
  • Vertebrate Orthologs
    2
  • Human Ortholog
    HRK, harakiri, BCL2 interacting protein
    Orthology source: HGNC
  • Synonyms
    DP5, HARAKIRI
  • Links
    NCBI Gene ID: 8739
    neXtProt AC: NX_O00198

  • Chr Location
    12q24.22; chr12:116860420-116881427 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Hrk
Homozygous mutants exhibit motoneurons that are protected from cell death induced by resection of the hypoglossal nerve and delayed cell death of superior cervical ganglia neurons triggered by nerve growth factor withdrawal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044796 VEGA Gene Model | MGI Sequence Detail 24831 C57BL/6J ±  kb
transcript OTTMUST00000117740 VEGA | MGI Sequence Detail 5382 Not Applicable  
polypeptide OTTMUSP00000065787 VEGA | MGI Sequence Detail 92 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    51 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008752 activator of apoptosis harakiri
  • InterPro Domains
    IPR017249 Activator of apoptosis harakiri
    IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
Molecular
Reagents
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  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140973
References
more
  • Summaries
    All 33
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:41987 Imaizumi K, et al., Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death. J Biol Chem. 1997 Jul 25;272(30):18842-8
  • Latest
    J:210416 Fernandes KA, et al., JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells. Exp Eye Res. 2013 Jul;112:106-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory