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Hrk Gene Detail
Summary
  • Symbol
    Hrk
  • Name
    harakiri, BCL2 interacting protein (contains only BH3 domain)
  • Synonyms
    Bid3, DP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201608
    NCBI Gene: 12123
  • Gene Overview
    MyGene.info: HRK
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:118169764-118189478 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 58.16 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201608
protein coding gene Chr5:118164648-118189478 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029994
protein coding gene Chr5:121318913-121346479 (+)
A/J MGP_AJ_G0029958
protein coding gene Chr5:116358773-116385047 (+)
AKR/J MGP_AKRJ_G0029897
protein coding gene Chr5:120114037-120143790 (+)
BALB/cJ MGP_BALBcJ_G0029969
protein coding gene Chr5:117782651-117809236 (+)
C3H/HeJ MGP_C3HHeJ_G0029689
protein coding gene Chr5:120649474-120677550 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030424
protein coding gene Chr5:125919826-125949484 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027650
protein coding gene Chr5:111118640-111143566 (+)
CAST/EiJ MGP_CASTEiJ_G0029098
protein coding gene Chr5:119668366-119693918 (+)
CBA/J MGP_CBAJ_G0029657
protein coding gene Chr5:130772735-130799892 (+)
DBA/2J MGP_DBA2J_G0029807
protein coding gene Chr5:116457559-116482983 (+)
FVB/NJ MGP_FVBNJ_G0029763
protein coding gene Chr5:115356096-115381845 (+)
LP/J MGP_LPJ_G0029895
protein coding gene Chr5:121806672-121835155 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029794
protein coding gene Chr5:134942810-134972440 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030465
protein coding gene Chr5:119669539-119697011 (+)
PWK/PhJ MGP_PWKPhJ_G0028811
protein coding gene Chr5:115168541-115195419 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028649
protein coding gene Chr5:117258379-117286786 (+)
WSB/EiJ MGP_WSBEiJ_G0029173
protein coding gene Chr5:120239733-120271924 (+)



Homology
more
  • Human Ortholog
    HRK, harakiri, BCL2 interacting protein
  • Vertebrate Orthologs
    2
  • Human Ortholog
    HRK, harakiri, BCL2 interacting protein
    Orthology source: HGNC
  • Synonyms
    DP5, HARAKIRI
  • Links
    NCBI Gene ID: 8739
    neXtProt AC: NX_O00198
    UniProt: O00198

  • Chr Location
    12q24.22; chr12:116856144-116881427 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit motoneurons that are protected from cell death induced by resection of the hypoglossal nerve and delayed cell death of superior cervical ganglia neurons triggered by nerve growth factor withdrawal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12123 NCBI Gene Model | MGI Sequence Detail 19715 C57BL/6J ±  kb
    transcript NM_007545 RefSeq | MGI Sequence Detail 5366 Not Specified  
    polypeptide P62816 UniProt | EBI | MGI Sequence Detail 92 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140973
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:210416 Fernandes KA, et al., JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells. Exp Eye Res. 2013 Jul;112:106-17

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory