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Hrk
Gene Detail
Symbol

Name
ID
Hrk
harakiri, BCL2 interacting protein (contains only BH3 domain)
MGI:1201608
Synonyms
Bid3, DP5
Feature Type
protein coding gene
Genetic Map
Chromosome 5
58.16 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:118164648-118189478 bp, + strand
From VEGA annotation of GRCm38

  24831 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137206  Vertebrate Homology Class
1 mouse; 1 rat

HCOP human homology predictions: HRK
Protein SuperFamily: activator of apoptosis harakiri
Gene Tree: Hrk

Human
homologs
HRK, harakiri, BCL2 interacting protein
Orthology source: HGNC

IDs:
NCBI Gene ID: 8739
neXtProt AC: NX_O00198

Human Synonyms: DP5, HARAKIRI

Human Chr (Location): 12q24.22; chr12:116860420-116881427 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Homozygous mutants exhibit motoneurons that are protected from cell death induced by resection of the hypoglossal nerve and delayed cell death of superior cervical ganglia neurons triggered by nerve growth factor withdrawal.
 
Interactions
Hrk interacts with 334 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process apoptotic process, cellular response to potassium ion starvation, ...
Component integral component of membrane, membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (29)    Tissues (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 18
Northern blot 10
RT-PCR 1
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000044796 (Evidence)
Ensembl Gene Model ENSMUSG00000046607 (Evidence)
Entrez Gene 12123 (Evidence)
UniGene 384468
DFCI TC1591042, TC1647102
DoTS DT.40185360
NIA Mouse Gene Index U042682
Consensus CDS Project CCDS39236.1
International Mouse Phenotyping Consortium Status Hrk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044796 VEGA Gene Model | MGI Sequence Detail 24831 C57BL/6J ±  kb
transcript OTTMUST00000117740 VEGA | MGI Sequence Detail 5382 Not Applicable 
polypeptide OTTMUSP00000065787 VEGA | MGI Sequence Detail 92 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017249 Activator of apoptosis harakiri
InterPro IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
Protein Ontology PR:000008752 activator of apoptosis harakiri
References
(Earliest) J:41987 Imaizumi K, et al., Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death. J Biol Chem. 1997 Jul 25;272(30):18842-8
(Latest) J:210416 Fernandes KA, et al., JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells. Exp Eye Res. 2013 Jul;112:106-17
All references(35)
Other
accession IDs
MGI:2140973

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory