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Hs3st1
Gene Detail
 Symbol
Name
ID
Hs3st1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
MGI:1201606
STS D5Dmo6
Synonyms 3-OST, D5Wsu110e
Feature Type protein coding gene
Genetic Map
Chromosome 5
21.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:39613935-39755475 bp, - strand
From VEGA annotation of GRCm38

  141541 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3751  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hs3st1

Human
homologs
Human Homolog HS3ST1, heparan sulfate (glucosamine) 3-O-sulfotransferase 1
NCBI Gene ID 9957
neXtProt AC  NX_O14792
Human Synonyms  3OST, 3OST1
Human Chr (Location)  4p16; chr4:11398364-11428913 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutation of this gene results in embryonic growth retardation and death between postnatal days 2-3 when bred on a C57BL/6J background. Mice homozygous for this mutation on a 129 background are normal.
 
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component Golgi apparatus
Function [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity, sulfotransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (224)    Tissues (134)    Images (26)
Theiler Stages: 11, 22, 23, 24, 28
Assay TypeResults
RNA in situ 201
RT-PCR 23
cDNA source data(46)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(49) cDNA(46) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029672 (Evidence)
Ensembl Gene ModelENSMUSG00000051022 (Evidence)
Entrez Gene15476 (Evidence)
UniGene12559
DFCITC1578972, TC1780228
DoTSDT.491144, DT.110679570, DT.94405201, DT.94405202
NIA Mouse Gene IndexU026144
EC2.8.2.23
PDB1VKJ, 3UAN
Consensus CDS ProjectCCDS19257.1
International Mouse Knockout Project StatusHs3st1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029672 VEGA Gene Model | MGI Sequence Detail 141541 C57BL/6J ±  kb
transcript OTTMUST00000073605 VEGA | MGI Sequence Detail 1686 Not Applicable 
polypeptide OTTMUSP00000038132 VEGA | MGI Sequence Detail 311 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(901 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000008758 heparan sulfate glucosamine 3-O-sulfotransferase 1
References (Earliest) J:43711 Shworak NW, et al., Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase. J Biol Chem. 1997 Oct 31;272(44):28008-19
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGD-MRK-34175, MGI:106481

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory