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Hs3st1
Gene Detail
Symbol

Name
ID
Hs3st1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
MGI:1201606
STS
Synonyms
3-OST, D5Wsu110e
Feature Type
protein coding gene
Genetic Map
Chromosome 5
21.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:39613935-39755475 bp, - strand
From VEGA annotation of GRCm38

  141541 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3751  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HS3ST1
Gene Tree: Hs3st1

Human
homologs
HS3ST1, heparan sulfate (glucosamine) 3-O-sulfotransferase 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9957
neXtProt AC: NX_O14792

Human Synonyms: 3OST, 3OST1

Human Chr (Location): 4p16; chr4:11398364-11429567 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Gene trapped(2) Radiation induced(2) Targeted(3)
Genomic Mutations involving Hs3st1 (3)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutation of this gene results in embryonic growth retardation and death between postnatal days 2-3 when bred on a C57BL/6J background. Mice homozygous for this mutation on a 129 background are normal.
 
Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Hs3st1 interacts with 116 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Component Golgi apparatus
Function 1-hydroxypyrene sulfotransferase activity, 1-phenanthrol sulfotransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (224)    Tissues (141)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 201
RT-PCR 23
cDNA source data(46)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HS3ST1 ; Xenbase hs3st1 ; ZFIN hs3st1    NEW 
Molecular
reagents
All nucleic(49) cDNA(46) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029672 (Evidence)
Ensembl Gene Model ENSMUSG00000051022 (Evidence)
Entrez Gene 15476 (Evidence)
UniGene 12559
DFCI TC1780228, TC1578972
DoTS DT.491144, DT.110679570, DT.94405202, DT.94405201
NIA Mouse Gene Index U026144
EC 2.8.2.-, 2.8.2.23
PDB 1VKJ, 3UAN
Consensus CDS Project CCDS19257.1
International Mouse Phenotyping Consortium Status Hs3st1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029672 VEGA Gene Model | MGI Sequence Detail 141541 C57BL/6J ±  kb
transcript OTTMUST00000073605 VEGA | MGI Sequence Detail 1686 Not Applicable 
polypeptide OTTMUSP00000038132 VEGA | MGI Sequence Detail 311 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(901 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000008758 heparan sulfate glucosamine 3-O-sulfotransferase 1
References
(Earliest) J:43711 Shworak NW, et al., Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase. J Biol Chem. 1997 Oct 31;272(44):28008-19
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Other
accession IDs
MGD-MRK-34175, MGI:106481

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory