About   Help   FAQ
Rdh5 Gene Detail
Summary
  • Symbol
    Rdh5
  • Name
    retinol dehydrogenase 5
  • Synonyms
    cRDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201412
    NCBI Gene: 19682
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128749457-128755906 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 77.19 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201412
 protein coding gene Chr10:128749457-128758757 (-)
129S1/SvImJ ENSMUSG00200012904
 protein coding gene Chr10:125107589-125112701 (-)
A/J ENSMUSG00195014251
 protein coding gene Chr10:125570910-125576023 (-)
AKR/J ENSMUSG00220005491
 protein coding gene Chr10:125175812-125180924 (-)
BALB/cJ ENSMUSG00180009341
 protein coding gene Chr10:125561899-125567012 (-)
C3H/HeJ ENSMUSG00175005590
 protein coding gene Chr10:125561030-125566142 (-)
C57BL/6NJ ENSMUSG00215012396
 protein coding gene Chr10:125167994-125173107 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015961
 protein coding gene Chr10:121277625-121287193 (-)
CAST/EiJ ENSTCUG00005034702
 protein coding gene Chr10:124552902-124558016 (-)
CBA/J ENSMUSG00210007807
 protein coding gene Chr10:125385268-125390380 (-)
DBA/2J ENSMUSG00185025678
 protein coding gene Chr10:125535033-125540145 (-)
FVB/NJ ENSMUSG00205016070
 protein coding gene Chr10:124776483-124781596 (-)
JF1/MsJ ENSUMUG00000041919
 protein coding gene Chr10:126843080-126848244 (-)
LP/J ENSMUSG00230031900
 protein coding gene Chr10:127460593-127465890 (-)
NOD/ShiLtJ ENSMUSG00190014946
 protein coding gene Chr10:125598662-125603775 (-)
NZO/HlLtJ ENSMUSG00225036731
 protein coding gene Chr10:131659612-131664724 (-)
PWK/PhJ ENSLUMG00010009764
 protein coding gene Chr10:125300911-125306073 (-)
SPRET/EiJ ENSMSPG00010027098
 protein coding gene Chr10:127258446-127264172 (-)
WSB/EiJ ENSIUOG00005008659
 protein coding gene Chr10:125182216-125187382 (-)



Homology
more
  • Human Ortholog
    RDH5, retinol dehydrogenase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RDH5, retinol dehydrogenase 5
  • Synonyms
    9cRDH, HSD17B9, RDH1, SDR9C5
  • Links
    NCBI Gene ID: 5959
    UniProt: Q92781

  • Chr Location
    12q13.2; chr12:55720367-55724710 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human RDH5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit an impaired dark adaptation and at high bleaching levels, a large increase in 11-cis-retinyl ester concentration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    900
  • Tissues
    202
  • cDNA Data
    20
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19682 NCBI Gene Model | MGI Sequence Detail 6450 C57BL/6J ±  kb
    transcript NM_001428784 RefSeq | MGI Sequence Detail 2405 C57BL/6  
    polypeptide O55240 UniProt | EBI | MGI Sequence Detail 318 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 21
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143706
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 9
      Gene Ontology 12
      Phenotypes 10
    • Earliest
      J:44704 Driessen CA, et al., Cloning and structural analysis of the murine GCN5L1 gene. Gene. 1997 Dec 5;203(1):27-31
    • Latest
      J:289971 Xie Y, et al., A spectral-domain optical coherence tomographic analysis of Rdh5-/- mice retina. PLoS One. 2020;15(4):e0231220
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory