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Rdh5
Gene Detail
Symbol

Name
ID
Rdh5
retinol dehydrogenase 5
MGI:1201412
Synonyms
cRDH
Feature Type
protein coding gene
Genetic Map
Chromosome 10
77.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:128913593-128922888 bp, - strand
From VEGA annotation of GRCm38

  9296 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2179  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: retinol dehydrogenase
Gene Tree: Rdh5

Human
homologs
Human Homolog RDH5, retinol dehydrogenase 5 (11-cis/9-cis)
NCBI Gene ID 5959
neXtProt AC  NX_Q92781
Human Synonyms  9cRDH, HSD17B9, RDH1, SDR9C5
Human Chr (Location)  12q13-q14; chr12:55720367-55724742 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RDH5
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Homozygotes for targeted null mutations exhibit an impaired dark adaptation and at high bleaching levels, a large increase in 11-cis-retinyl ester concentration.
 
Interactions
Rdh5 interacts with 34 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process metabolic process, oxidation-reduction process, ...
Component cell body, endoplasmic reticulum, ...
Function oxidoreductase activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (197)    Tissues (113)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 188
RT-PCR 9
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(19) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033473 (Evidence)
Ensembl Gene ModelENSMUSG00000025350 (Evidence)
Entrez Gene19682 (Evidence)
UniGene439856
DFCITC1596548, TC1582521
DoTSDT.55177573, DT.521591, DT.101165660, DT.97360000
NIA Mouse Gene IndexU032381
EC1.1.1.315
Consensus CDS ProjectCCDS24298.1
International Mouse Knockout Project StatusRdh5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033473 VEGA Gene Model | MGI Sequence Detail 9296 C57BL/6J ±  kb
transcript OTTMUST00000084113 VEGA | MGI Sequence Detail 1258 Not Applicable 
polypeptide OTTMUSP00000045282 VEGA | MGI Sequence Detail 318 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(10) UniProt(11)
Polymorphisms
PCR(1) : SNPs within 2kb(73 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000013854 11-cis retinol dehydrogenase
References
(Earliest) J:44704 Driessen CA, et al., Cloning and structural analysis of the murine GCN5L1 gene. Gene. 1997 Dec 5;203(1):27-31
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(43)
Other
accession IDs
MGI:2143706

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory