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Rdh5 Gene Detail
Summary
  • Symbol
    Rdh5
  • Name
    retinol dehydrogenase 5
  • Synonyms
    cRDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201412
    NCBI Gene: 19682
  • Gene Overview
    MyGene.info: RDH5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128913588-128919297 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 77.19 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201412
protein coding gene Chr10:128913588-128922888 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017889
protein coding gene Chr10:132714601-132723878 (-)
A/J MGP_AJ_G0017864
protein coding gene Chr10:127370476-127379772 (-)
AKR/J MGP_AKRJ_G0017827
protein coding gene Chr10:131086178-131097063 (-)
BALB/cJ MGP_BALBcJ_G0017828
protein coding gene Chr10:127730344-127739642 (-)
C3H/HeJ MGP_C3HHeJ_G0017651
protein coding gene Chr10:131262706-131272052 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018283
protein coding gene Chr10:137186766-137196059 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015961
protein coding gene Chr10:121277625-121287193 (-)
CAST/EiJ MGP_CASTEiJ_G0017212
protein coding gene Chr10:131990089-132001623 (-)
CBA/J MGP_CBAJ_G0017621
protein coding gene Chr10:142784294-142793644 (-)
DBA/2J MGP_DBA2J_G0017727
protein coding gene Chr10:126427607-126437028 (-)
FVB/NJ MGP_FVBNJ_G0017722
protein coding gene Chr10:125348753-125358312 (-)
LP/J MGP_LPJ_G0017801
protein coding gene Chr10:133291683-133301587 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017750
protein coding gene Chr10:145339608-145348946 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018323
protein coding gene Chr10:131196006-131205284 (-)
PWK/PhJ MGP_PWKPhJ_G0016997
protein coding gene Chr10:126696739-126706115 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016786
protein coding gene Chr10:130312251-130321578 (-)
WSB/EiJ MGP_WSBEiJ_G0017271
protein coding gene Chr10:131428207-131437483 (-)



Homology
more
  • Human Ortholog
    RDH5, retinol dehydrogenase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RDH5, retinol dehydrogenase 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    9cRDH, HSD17B9, RDH1, SDR9C5
  • Links
    NCBI Gene ID: 5959
    neXtProt AC: NX_Q92781
    UniProt: Q92781

  • Chr Location
    12q13.2; chr12:55720367-55724742 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RDH5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit an impaired dark adaptation and at high bleaching levels, a large increase in 11-cis-retinyl ester concentration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19682 NCBI Gene Model | MGI Sequence Detail 5710 C57BL/6J ±  kb
transcript NM_001358527 RefSeq | MGI Sequence Detail 1281 C57BL/6  
polypeptide O55240 UniProt | EBI | MGI Sequence Detail 318 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 1
    cDNA 20
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143706
References
more
  • Summaries
    All 40
    Developmental Gene Expression 7
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:44704 Driessen CA, et al., Cloning and structural analysis of the murine GCN5L1 gene. Gene. 1997 Dec 5;203(1):27-31
  • Latest
    J:226552 Sahu B, et al., Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J Biol Chem. 2015 Nov 6;290(45):27239-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory