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Srpk2 Gene Detail
Summary
  • Symbol
    Srpk2
  • Name
    serine/arginine-rich protein specific kinase 2
  • Synonyms
    mSRPK2, WBP6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201408
    NCBI Gene: 20817
  • Gene Overview
    MyGene.info: SRPK2
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:23503356-23684643 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 10.36 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1502 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201408
protein coding gene Chr5:23503264-23684643 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029330
protein coding gene Chr5:21160826-21350381 (-)
A/J MGP_AJ_G0029296
protein coding gene Chr5:20477997-20653723 (-)
AKR/J MGP_AKRJ_G0029247
protein coding gene Chr5:21274514-21468768 (-)
BALB/cJ MGP_BALBcJ_G0029307
protein coding gene Chr5:20963518-21143719 (-)
C3H/HeJ MGP_C3HHeJ_G0029027
protein coding gene Chr5:21362058-21554787 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029760
protein coding gene Chr5:22637263-22826608 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026998
protein coding gene Chr5:18431694-18611362 (-)
CAST/EiJ MGP_CASTEiJ_G0028439
protein coding gene Chr5:20565605-20753627 (-)
CBA/J MGP_CBAJ_G0028994
protein coding gene Chr5:22959039-23158529 (-)
DBA/2J MGP_DBA2J_G0029145
protein coding gene Chr5:20739288-20915269 (-)
FVB/NJ MGP_FVBNJ_G0029103
protein coding gene Chr5:20137342-20314673 (-)
LP/J MGP_LPJ_G0029229
protein coding gene Chr5:21538274-21731251 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029132
protein coding gene Chr5:24142336-24331830 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029794
protein coding gene Chr5:20869121-21068064 (-)
PWK/PhJ MGP_PWKPhJ_G0028162
protein coding gene Chr5:19822497-20005543 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027994
protein coding gene Chr5:20272762-20456050 (-)
WSB/EiJ MGP_WSBEiJ_G0028519
protein coding gene Chr5:20964716-21163281 (-)



Homology
more
  • Human Ortholog
    SRPK2, SRSF protein kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SRPK2, SRSF protein kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SFRSK2
  • Links
    NCBI Gene ID: 6733
    neXtProt AC: NX_P78362
    UniProt: P78362

  • Chr Location
    7q22.3; chr7:105110708-105399366 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from multigenic genotypes
    18 phenotype references
Mice homozygous for a targeted allele exhibit normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20817 NCBI Gene Model | MGI Sequence Detail 181288 C57BL/6J ±  kb
transcript NM_001359172 RefSeq | MGI Sequence Detail 6449 C57BL/6  
polypeptide O54781 UniProt | EBI | MGI Sequence Detail 681 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    14 Sequences
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 38
    cDNA 37
    Primer pair 1

    Microarray probesets 10
Other
Accession IDs
less
MGD-MRK-39565, MGI:109566, MGI:2141179, MGI:2141199, MGI:2141220
References
more
  • Summaries
    All 56
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 9
    Phenotypes 18
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory