Slc10a2
Gene Detail

Symbol Name ID

Slc10a2 solute carrier family 10, member 2 MGI:1201406

Synonyms

ASBT

Feature Type

protein coding gene

Genetic Map

Chromosome 8

2.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:5085623-5105232 bp, - strand From NCBI annotation of GRCm38   19610 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:390  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sodium-dependent transporter
Gene Tree: Slc10a2

Human homologs

Human Homolog		SLC10A2, solute carrier family 10 (sodium/bile acid cotransporter family), member 2
NCBI Gene ID		6555
neXtProt AC		NX_Q12908
Human Synonyms		ASBT, IBAT, ISBT, NTCP2, PBAM
Human Chr (Location)		13q33; chr13:103696348-103719196 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC10A2

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for disruptions in this gene are essentially indistinguishable from wild-type in terms of survival, gross appearance and behavior. However, they do have defects in lipid absorption from the intestine.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	bile acid and bile salt transport, ion transport, ...
Component	apical plasma membrane, integral to membrane, ...
Function	bile acid:sodium symporter activity, symporter activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(4) cDNA(3) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000023073 (Evidence)
Entrez Gene	20494 (Evidence)
UniGene	3500
DFCI	TC1594774, TC1599445
DoTS	DT.40140177
Consensus CDS Project	CCDS22089.1
International Mouse Knockout Project Status	Slc10a2

Sequences

Length	Strain/Species
genomic	20494	NCBI Gene Model | MGI Sequence Detail	19610	C57BL/6J
transcript	NM_011388	RefSeq | MGI Sequence Detail	1629	C57BL/6
polypeptide	P70172	UniProt | EBI | MGI Sequence Detail	348	Not Applicable

All sequences(18) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(71 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002657	Bile acid:sodium symporter
InterPro	IPR004710	Bile acid transporter
Protein Ontology	PR:000014918	ileal sodium/bile acid cotransporter

Graphical View of Protein Domain Structure

References

(Earliest) J:42394 Lammert F, et al., Localization of the ileal sodium-bile salt cotransporter gene (Slc10a2) to mouse chromosome 8. Mamm Genome. 1998 Feb;9(2):173-4
(Latest) J:163323 Halpern MD, et al., Apical sodium-dependent bile acid transporter upregulation is associated with necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G623-31
All references(31)