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Slc10a2 Gene Detail
Summary
  • Symbol
    Slc10a2
  • Name
    solute carrier family 10, member 2
  • Synonyms
    9130221J18Rik, ASBT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201406
    NCBI Gene: 20494
  • Gene Overview
    MyGene.info: SLC10A2
Location & Maps
more
  • Genetic Map
    Chromosome 8, 2.16 cM
  • Mapping Data
    5 experiments
Homology
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  • Human Ortholog
    SLC10A2, solute carrier family 10 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC10A2, solute carrier family 10 member 2
    Orthology source: HomoloGene
  • Synonyms
    ASBT, IBAT, ISBT, NTCP2, PBAM
  • Links
    NCBI Gene ID: 6555
    neXtProt AC: NX_Q12908

  • Chr Location
    13q33; chr13:103043998-103066846 (-)  GRCh38.p2

Human Diseases
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  • Diseases
    1 with human SLC10A2 associations

Human Disease Mouse Models
       Bile Acid Malabsorption, Primary; PBAM   OMIM: 613291
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are essentially indistinguishable from wild-type in terms of survival, gross appearance and behavior. However, they do have defects in lipid absorption from the intestine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059770 VEGA Gene Model | MGI Sequence Detail 22133 C57BL/6J ±  kb
transcript OTTMUST00000146505 VEGA | MGI Sequence Detail 4152 Not Applicable  
polypeptide OTTMUSP00000076267 VEGA | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    245 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014918 ileal sodium/bile acid cotransporter
  • InterPro Domains
    IPR004710 Bile acid:sodium symporter
    IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3
    IPR030207 Solute carrier family 10 member 2
Molecular
Reagents
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  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2142592
References
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  • Summaries
    All 44
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:42394 Lammert F, et al., Localization of the ileal sodium-bile salt cotransporter gene (Slc10a2) to mouse chromosome 8. Mamm Genome. 1998 Feb;9(2):173-4
  • Latest
    J:227211 Zhang Y, et al., Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015;6:8186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory