About   Help   FAQ
Slc10a2
Gene Detail
Symbol

Name
ID
Slc10a2
solute carrier family 10, member 2
MGI:1201406
Synonyms
ASBT
Feature Type
protein coding gene
Genetic Map
Chromosome 8
2.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:5085623-5105232 bp, - strand
From NCBI annotation of GRCm38

  19610 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:390  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sodium-dependent transporter
Gene Tree: Slc10a2

Human
homologs
Human Homolog SLC10A2, solute carrier family 10 (sodium/bile acid cotransporter), member 2
NCBI Gene ID 6555
neXtProt AC  NX_Q12908
Human Synonyms  ASBT, IBAT, ISBT, NTCP2, PBAM
Human Chr (Location)  13q33; chr13:103043998-103066846 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC10A2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene are essentially indistinguishable from wild-type in terms of survival, gross appearance and behavior. However, they do have defects in lipid absorption from the intestine.
 
Interactions
Slc10a2 interacts with 111 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(3) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000023073 (Evidence)
Entrez Gene20494 (Evidence)
UniGene3500
DFCITC1594774, TC1599445
DoTSDT.40140177
Consensus CDS ProjectCCDS22089.1
International Mouse Knockout Project StatusSlc10a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20494 NCBI Gene Model | MGI Sequence Detail 19610 C57BL/6J ±  kb
transcript NM_011388 RefSeq | MGI Sequence Detail 1629 C57BL/6 
polypeptide P70172 UniProt | EBI | MGI Sequence Detail 348 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(231 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002657 Bile acid:sodium symporter
InterPro IPR004710 Bile acid transporter
Protein Ontology PR:000014918 ileal sodium/bile acid cotransporter
Graphical View of Protein Domain Structure
References
(Earliest) J:42394 Lammert F, et al., Localization of the ileal sodium-bile salt cotransporter gene (Slc10a2) to mouse chromosome 8. Mamm Genome. 1998 Feb;9(2):173-4
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory