About   Help   FAQ
Slc10a2 Gene Detail
Summary
  • Symbol
    Slc10a2
  • Name
    solute carrier family 10, member 2
  • Synonyms
    9130221J18Rik, ASBT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201406
    NCBI Gene: 20494
  • Gene Overview
    MyGene.info: SLC10A2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:5083219-5105287 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 2.16 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201406
protein coding gene Chr8:5083219-5105351 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033339
protein coding gene Chr8:2087663-2107247 (-)
A/J MGP_AJ_G0033320
protein coding gene Chr8:1996025-2016474 (-)
AKR/J MGP_AKRJ_G0033251
protein coding gene Chr8:2076410-2098487 (-)
BALB/cJ MGP_BALBcJ_G0033320
protein coding gene Chr8:2090927-2110380 (-)
C3H/HeJ MGP_C3HHeJ_G0033034
protein coding gene Chr8:2134414-2155137 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033832
protein coding gene Chr8:2166806-2187096 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030804
protein coding gene Chr8:1835653-1855036 (-)
CAST/EiJ MGP_CASTEiJ_G0032357
protein coding gene Chr8:1921102-1940714 (-)
CBA/J MGP_CBAJ_G0033007
protein coding gene Chr8:2222572-2242105 (-)
DBA/2J MGP_DBA2J_G0033161
protein coding gene Chr8:1956521-1976391 (-)
FVB/NJ MGP_FVBNJ_G0033108
protein coding gene Chr8:1995666-2015265 (-)
LP/J MGP_LPJ_G0033255
protein coding gene Chr8:1988716-2008332 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033143
protein coding gene Chr8:2249932-2270633 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033849
protein coding gene Chr8:2049798-2070775 (-)
PWK/PhJ MGP_PWKPhJ_G0032069
protein coding gene Chr8:1949949-1969738 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031912
protein coding gene Chr8:1948987-1968690 (-)
WSB/EiJ MGP_WSBEiJ_G0032472
protein coding gene Chr8:2035040-2054492 (-)



Homology
more
  • Human Ortholog
    SLC10A2, solute carrier family 10 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC10A2, solute carrier family 10 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASBT, IBAT, ISBT, NTCP2, PBAM
  • Links
    NCBI Gene ID: 6555
    neXtProt AC: NX_Q12908
    UniProt: Q12908

  • Chr Location
    13q33.1; chr13:103043998-103066846 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are essentially indistinguishable from wild-type in terms of survival, gross appearance and behavior. However, they do have defects in lipid absorption from the intestine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20494 NCBI Gene Model | MGI Sequence Detail 22069 C57BL/6J ±  kb
transcript NM_011388 RefSeq | MGI Sequence Detail 4088 C57BL/6  
polypeptide P70172 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2142592
References
more
  • Summaries
    All 49
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:42394 Lammert F, et al., Localization of the ileal sodium-bile salt cotransporter gene (Slc10a2) to mouse chromosome 8. Mamm Genome. 1998 Feb;9(2):173-4
  • Latest
    J:233745 Ferrell JM, et al., Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders. J Lipid Res. 2016 Jul;57(7):1144-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory