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Gfra3 Gene Detail
Summary
  • Symbol
    Gfra3
  • Name
    glial cell line derived neurotrophic factor family receptor alpha 3
  • Synonyms
    GFRalpha3, GFR alpha-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201403
    NCBI Gene: 14587
  • Gene Overview
    MyGene.info: GFRA3
Location & Maps
more
  • Sequence Map
    Chr18:34689903-34720387 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30485 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 18.69 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GFRA3, GDNF family receptor alpha 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GFRA3, GDNF family receptor alpha 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GDNFR3
  • Links
    NCBI Gene ID: 2676
    neXtProt AC: NX_O60609

  • Chr Location
    5q31.2; chr5:138252380-138274564 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    6
  • Incidental Mutations
Mice homozygous for disruption of this gene display ptosis and poor development of the sympathetic chain ganglia and associated nerves.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14587 NCBI Gene Model | MGI Sequence Detail 30485 C57BL/6J ±  kb
transcript NM_010280 RefSeq | MGI Sequence Detail 1997 C57BL/6  
polypeptide O35118 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    179 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 1
    cDNA 21
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2147424
References
more
  • Summaries
    All 49
    Developmental Gene Expression 20
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:45661 Naveilhan P, et al., Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1295-300
  • Latest
    J:232109 Lippoldt EK, et al., Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFRalpha3. Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4506-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory