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Ccr8 Gene Detail
Summary
  • Symbol
    Ccr8
  • Name
    chemokine (C-C motif) receptor 8
  • Synonyms
    Cmkbr8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201402
    NCBI Gene: 12776
  • Gene Overview
    MyGene.info: CCR8
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:120092133-120094906 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.39 cM, cytoband F4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201402
protein coding gene Chr9:120092114-120094906 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035430
protein coding gene Chr9:122911262-122914039 (+)
A/J MGP_AJ_G0035411
protein coding gene Chr9:118312533-118315311 (+)
AKR/J MGP_AKRJ_G0035344
protein coding gene Chr9:121398946-121401718 (+)
BALB/cJ MGP_BALBcJ_G0035407
protein coding gene Chr9:118199997-118202776 (+)
C3H/HeJ MGP_C3HHeJ_G0035115
protein coding gene Chr9:121878213-121880992 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035930
protein coding gene Chr9:126273577-126276350 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032812
protein coding gene Chr9:115512464-115515654 (+)
CAST/EiJ MGP_CASTEiJ_G0034419
protein coding gene Chr9:121897110-121899880 (+)
CBA/J MGP_CBAJ_G0035082
protein coding gene Chr9:130989404-130992176 (+)
DBA/2J MGP_DBA2J_G0035241
protein coding gene Chr9:117757426-117760198 (+)
FVB/NJ MGP_FVBNJ_G0035188
protein coding gene Chr9:116636665-116639444 (+)
LP/J MGP_LPJ_G0035320
protein coding gene Chr9:123244174-123246951 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035229
protein coding gene Chr9:131931247-131934020 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035949
protein coding gene Chr9:121797213-121799986 (+)
PWK/PhJ MGP_PWKPhJ_G0034124
protein coding gene Chr9:118198392-118201187 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033960
protein coding gene Chr9:121903864-121906632 (+)
WSB/EiJ MGP_WSBEiJ_G0034539
protein coding gene Chr9:121688608-121691386 (+)



Homology
more
  • Human Ortholog
    CCR8, C-C motif chemokine receptor 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CCR8, C-C motif chemokine receptor 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1
  • Links
    NCBI Gene ID: 1237
    neXtProt AC: NX_P51685
    UniProt: P51685

  • Chr Location
    3p22.1; chr3:39329706-39333680 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for either of two independently generated knock-out alleles show normal lung eosinophilia and Th2 cytokine responses in OVA-elicited asthma models. Mice homozygous for a third knock-out allele show a delay in onset of clinical signs of experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12776 NCBI Gene Model | MGI Sequence Detail 2774 C57BL/6J ±  kb
transcript NM_007720 RefSeq | MGI Sequence Detail 1156 Not Specified  
polypeptide P56484 UniProt | EBI | MGI Sequence Detail 353 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    Genomic 2
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 49
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 22
  • Earliest
    J:45667 Goya I, et al., Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. J Immunol. 1998 Feb 15;160(4):1975-81
  • Latest
    J:264102 Thyagarajan HM, et al., CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction. PLoS One. 2018;13(7):e0200765

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory