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Ccr8
Gene Detail
 Symbol
Name
ID
Ccr8
chemokine (C-C motif) receptor 8
MGI:1201402
Synonyms Cmkbr8
Feature Type protein coding gene
Genetic Map
Chromosome 9
71.39 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:120092133-120094906 bp, + strand
From NCBI annotation of GRCm38

  2774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21080  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr8

Human
homologs
Human Homolog CCR8, chemokine (C-C motif) receptor 8
NCBI Gene ID 1237
neXtProt AC  NX_P51685
Human Synonyms  CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1
Human Chr (Location)  3p22; chr3:39329706-39333680 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice homozygous for either of two independently generated knock-out alleles show normal lung eosinophilia and Th2 cytokine responses in OVA-elicited asthma models. Mice homozygous for a third knock-out allele show a delay in onset of clinical signs of experimental autoimmune encephalomyelitis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chemokine-mediated signaling pathway, chemotaxis, ...
Component integral component of membrane, membrane, ...
Function C-C chemokine receptor activity, chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (20)    Images (12)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 34
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) Genomic(2) cDNA(9)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000042262 (Evidence)
Entrez Gene12776 (Evidence)
UniGene442098
DFCITC1593944, TC1596779, TC1757006
DoTSDT.40143730
NIA Mouse Gene IndexU011151
Consensus CDS ProjectCCDS23621.1
International Mouse Knockout Project StatusCcr8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12776 NCBI Gene Model | MGI Sequence Detail 2774 C57BL/6J ±  kb
transcript NM_007720 RefSeq | MGI Sequence Detail 1156 Not Specified 
polypeptide P56484 UniProt | EBI | MGI Sequence Detail 353 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004068 CC chemokine receptor 8
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001204 C-C chemokine receptor type 8
Graphical View of Protein Domain Structure
References (Earliest) J:45667 Goya I, et al., Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. J Immunol. 1998 Feb 15;160(4):1975-81
(Latest) J:203829 Islam SA, et al., Identification of human CCR8 as a CCL18 receptor. J Exp Med. 2013 Sep 23;210(10):1889-98
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory