Ccr8
Gene Detail

Symbol Name ID

Ccr8 chemokine (C-C motif) receptor 8 MGI:1201402

Synonyms

Cmkbr8

Feature Type

protein coding gene

Genetic Map

Chromosome 9

71.39 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:120092133-120094906 bp, + strand From NCBI annotation of GRCm38   2774 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21080  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr8

Human homologs

Human Homolog		CCR8, chemokine (C-C motif) receptor 8
NCBI Gene ID		1237
neXtProt AC		NX_P51685
Human Synonyms		CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1
Human Chr (Location)		3p22; chr3:39371197-39375171 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for either of two independently generated knock-out alleles show normal lung eosinophilia and Th2 cytokine responses in OVA-elicited asthma models. Mice homozygous for a third knock-out allele show a delay in onset of clinical signs of experimental autoimmune encephalomyelitis.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	chemokine-mediated signaling pathway, chemotaxis, ...
Component	integral to membrane, membrane, ...
Function	C-C chemokine receptor activity, chemokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (20)    Images (12)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	34

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) Genomic(2) cDNA(9)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000042262 (Evidence)
Entrez Gene	12776 (Evidence)
UniGene	442098
DFCI	TC1593944, TC1596779, TC1757006
DoTS	DT.40143730
NIA Mouse Gene Index	U011151
Consensus CDS Project	CCDS23621.1
International Mouse Knockout Project Status	Ccr8

Sequences

Length	Strain/Species
genomic	12776	NCBI Gene Model | MGI Sequence Detail	2774	C57BL/6J
transcript	NM_007720	RefSeq | MGI Sequence Detail	1156	Not Specified
polypeptide	P56484	UniProt | EBI | MGI Sequence Detail	353	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(37 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004068	CC chemokine receptor 8
InterPro	IPR000355	Chemokine receptor family
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001204	C-C chemokine receptor type 8

Graphical View of Protein Domain Structure

References

(Earliest) J:45667 Goya I, et al., Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. J Immunol. 1998 Feb 15;160(4):1975-81
(Latest) J:187644 Nagao K, et al., Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin. Nat Immunol. 2012;13(8):744-52
All references(39)