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Ccr8
Gene Detail
Symbol

Name
ID
Ccr8
chemokine (C-C motif) receptor 8
MGI:1201402
Synonyms
Cmkbr8
Feature Type
protein coding gene
Genetic Map
Chromosome 9
71.39 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:120092133-120094906 bp, + strand
From NCBI annotation of GRCm38

  2774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21080  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

HCOP human homology predictions: CCR8
Protein SuperFamily: chemokine receptor
Gene Tree: Ccr8

Human
homologs
CCR8, chemokine (C-C motif) receptor 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1237
neXtProt AC: NX_P51685

Human Synonyms: CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1

Human Chr (Location): 3p22; chr3:39329706-39333680 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for either of two independently generated knock-out alleles show normal lung eosinophilia and Th2 cytokine responses in OVA-elicited asthma models. Mice homozygous for a third knock-out allele show a delay in onset of clinical signs of experimental autoimmune encephalomyelitis.
 
Interactions
Ccr8 interacts with 5 markers (Mir93, Mir147, Mir494, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chemokine-mediated signaling pathway, chemotaxis, ...
Component integral component of membrane, membrane, ...
Function C-C chemokine receptor activity, chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (20)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 34
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ccr8.1    NEW 
Molecular
reagents
All nucleic(11) Genomic(2) cDNA(9)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000042262 (Evidence)
Entrez Gene 12776 (Evidence)
UniGene 442098
DFCI TC1593944, TC1596779, TC1757006
DoTS DT.40143730
NIA Mouse Gene Index U011151
Consensus CDS Project CCDS23621.1
International Mouse Phenotyping Consortium Status Ccr8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12776 NCBI Gene Model | MGI Sequence Detail 2774 C57BL/6J ±  kb
transcript NM_007720 RefSeq | MGI Sequence Detail 1156 Not Specified 
polypeptide P56484 UniProt | EBI | MGI Sequence Detail 353 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004068 CC chemokine receptor 8
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001204 C-C chemokine receptor type 8
Graphical View of Protein Domain Structure
References
(Earliest) J:45667 Goya I, et al., Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. J Immunol. 1998 Feb 15;160(4):1975-81
(Latest) J:215014 Oshio T, et al., Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages. PLoS One. 2014;9(4):e94445
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory