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Nrdc Gene Detail
Summary
  • Symbol
    Nrdc
  • Name
    nardilysin convertase
  • Synonyms
    MGC:25477, Nrd1, NRD-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201386
    NCBI Gene: 230598
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:108857852-108918974 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 50.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    253 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201386
protein coding gene Chr4:108857852-108918974 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028566
protein coding gene Chr4:109762850-109826153 (+)
A/J MGP_AJ_G0028529
protein coding gene Chr4:105811745-105873533 (+)
AKR/J MGP_AKRJ_G0028476
protein coding gene Chr4:108445901-108508878 (+)
BALB/cJ MGP_BALBcJ_G0028548
protein coding gene Chr4:106012485-106082205 (+)
C3H/HeJ MGP_C3HHeJ_G0028262
protein coding gene Chr4:109183124-109243737 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028988
protein coding gene Chr4:113706390-113776036 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026279
protein coding gene Chr4:101098991-101162585 (+)
CAST/EiJ MGP_CASTEiJ_G0027698
protein coding gene Chr4:107037760-107099348 (+)
CBA/J MGP_CBAJ_G0028231
protein coding gene Chr4:117437864-117503039 (+)
DBA/2J MGP_DBA2J_G0028379
protein coding gene Chr4:105434290-105495064 (+)
FVB/NJ MGP_FVBNJ_G0028347
protein coding gene Chr4:104302272-104363745 (+)
LP/J MGP_LPJ_G0028480
protein coding gene Chr4:110003266-110070347 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028373
protein coding gene Chr4:122640434-122703792 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029024
protein coding gene Chr4:108685936-108749943 (+)
PWK/PhJ MGP_PWKPhJ_G0027424
protein coding gene Chr4:103716028-103780245 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027248
protein coding gene Chr4:106051027-106117101 (+)
WSB/EiJ MGP_WSBEiJ_G0027779
protein coding gene Chr4:108862258-108925022 (+)



Homology
more
  • Human Ortholog
    NRDC, nardilysin convertase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRDC, nardilysin convertase
  • Synonyms
    hNRD1, hNRD2, NRD1
  • Links
    NCBI Gene ID: 4898
    neXtProt AC: NX_O43847
    UniProt: O43847

  • Chr Location
    1p32.3; chr1:51789191-51878805 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele mostly die within 48 hours of birth with surviving mice exhibiting cortical thinning, enlarged lateral ventricles, hypomyelination, reduced grip strength, impaired coordination, and impaired spatial working memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230598 NCBI Gene Model | MGI Sequence Detail 61123 C57BL/6J ±  kb
    transcript NM_001347169 RefSeq | MGI Sequence Detail 4529 C57BL/6  
    polypeptide Q8BHG1 UniProt | EBI | MGI Sequence Detail 1161 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140402
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:45959 Fumagalli P, et al., Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. Genomics. 1998 Jan 15;47(2):238-45
    • Latest
      J:321669 Saijo S, et al., Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis. Sci Rep. 2022 Mar 2;12(1):3449

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory