Nrd1
Gene Detail

Symbol Name ID

Nrd1 nardilysin, N-arginine dibasic convertase, NRD convertase 1 MGI:1201386

Synonyms

MGC:25477, NRD-C

Feature Type

protein coding gene

Genetic Map

Chromosome 4

50.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:109000655-109061777 bp, + strand From VEGA annotation of GRCm38   61123 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: insulin-degrading enzyme (IDE)/zinc protease
Gene Tree: Nrd1

Human homologs

Human Homolog		NRD1, nardilysin (N-arginine dibasic convertase)
NCBI Gene ID		4898
neXtProt AC		NX_O43847
Human Synonyms		hNRD1, hNRD2
Human Chr (Location)		1p32.2-p32.1; chr1:52254864-52344609 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(3) Gene trapped(12)
 

Mice homozygous for a knock-out allele mostly die within 48 hours of birth with surviving mice exhibiting cortical thinning, enlarged lateral ventricles, hypomyelination, reduced grip strength, impaired coordination, and impaired spatial working memory.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	positive regulation of membrane protein ectodomain proteolysis, proteolysis, ...
Component	mitochondrion
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 22, 24

Assay Type	Results
RNA in situ	2

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(16)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000008296 (Evidence)
Ensembl Gene Model	ENSMUSG00000053510 (Evidence)
Entrez Gene	230598 (Evidence)
NIA Mouse Gene Index	U004633
EC	3.4.24.61
Consensus CDS Project	CCDS18460.1
International Mouse Knockout Project Status	Nrd1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008296	VEGA Gene Model | MGI Sequence Detail	61123	C57BL/6J
transcript	OTTMUST00000018881	VEGA | MGI Sequence Detail	3784	Not Applicable
polypeptide	OTTMUSP00000008674	VEGA | MGI Sequence Detail	1229	Not Applicable

All sequences(62) RefSeq(2) UniProt(8)

Protein-related information

Resource	ID	Description
InterPro	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like
InterPro	IPR007863	Peptidase M16, C-terminal domain
InterPro	IPR011237	Peptidase M16 domain
InterPro	IPR011765	Peptidase M16, N-terminal
InterPro	IPR001431	Peptidase M16, zinc-binding site
Protein Ontology	PR:000011421	nardilysin

References

(Earliest) J:45959 Fumagalli P, et al., Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. Genomics. 1998 Jan 15;47(2):238-45
(Latest) J:174238 Rorick NK, et al., Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome. Am J Med Genet A. 2011 Jun;155A(6):1314-21
All references(37)

Other accession IDs

MGI:2140402