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Nrd1
Gene Detail
Symbol

Name
ID
Nrd1
nardilysin, N-arginine dibasic convertase, NRD convertase 1
MGI:1201386
Synonyms
MGC:25477, NRD-C
Feature Type
protein coding gene
Genetic Map
Chromosome 4
50.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:109000655-109061777 bp, + strand
From VEGA annotation of GRCm38

  61123 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: insulin-degrading enzyme (IDE)/zinc protease
Gene Tree: Nrd1

Human
homologs
Human Homolog NRD1, nardilysin (N-arginine dibasic convertase)
NCBI Gene ID 4898
neXtProt AC  NX_O43847
Human Synonyms  hNRD1, hNRD2
Human Chr (Location)  1p32.2-p32.1; chr1:51789192-51878937 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele mostly die within 48 hours of birth with surviving mice exhibiting cortical thinning, enlarged lateral ventricles, hypomyelination, reduced grip strength, impaired coordination, and impaired spatial working memory.
 
Interactions
Nrd1 interacts with 158 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process positive regulation of membrane protein ectodomain proteolysis, proteolysis, ...
Component mitochondrion
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000008296 (Evidence)
Ensembl Gene ModelENSMUSG00000053510 (Evidence)
Entrez Gene230598 (Evidence)
NIA Mouse Gene IndexU004633
EC3.4.24.61
Consensus CDS ProjectCCDS18460.1
International Mouse Knockout Project StatusNrd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008296 VEGA Gene Model | MGI Sequence Detail 61123 C57BL/6J ±  kb
transcript OTTMUST00000018881 VEGA | MGI Sequence Detail 3784 Not Applicable 
polypeptide OTTMUSP00000008674 VEGA | MGI Sequence Detail 1229 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(10) UniProt(15)
Polymorphisms
SNPs within 2kb(253 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
InterPro IPR007863 Peptidase M16, C-terminal domain
InterPro IPR011237 Peptidase M16 domain
InterPro IPR011765 Peptidase M16, N-terminal
InterPro IPR001431 Peptidase M16, zinc-binding site
Protein Ontology PR:000011421 nardilysin
References
(Earliest) J:45959 Fumagalli P, et al., Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. Genomics. 1998 Jan 15;47(2):238-45
(Latest) J:212603 Bernstein HG, et al., Nardilysin, ADAM10, and Alzheimer's disease: of mice and men. Neurobiol Aging. 2014 Mar;35(3):e1
All references(39)
Other
accession IDs
MGI:2140402

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory