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Irx2
Gene Detail
 Symbol
Name
ID
Irx2
Iroquois related homeobox 2 (Drosophila)
MGI:1197526
Synonyms IRX6
Feature Type protein coding gene
Genetic Map
Chromosome 13
39.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:72628820-72634198 bp, + strand
From VEGA annotation of GRCm38

  5379 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Irx2

Human
homologs
Human Homolog IRX2, iroquois homeobox 2
NCBI Gene ID 153572
neXtProt AC  NX_Q9BZI1
Human Synonyms  IRXA2
Human Chr (Location)  5p15.33; chr5:2746165-2751655 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene are phenotypically normal.
 
Interactions
Irx2 interacts with 204 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process regulation of transcription, DNA-templated
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (516)    Tissues (255)    Images (86)
Theiler Stages: 2, 3, 9, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 468
Northern blot 1
RT-PCR 47
cDNA source data(122)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(127) cDNA(122) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036811 (Evidence)
Ensembl Gene ModelENSMUSG00000001504 (Evidence)
Entrez Gene16372 (Evidence)
UniGene28888
DFCITC1577611, TC1587352, TC1644118
DoTSDT.110962466, DT.530785, DT.91444645
NIA Mouse Gene IndexU014992
Consensus CDS ProjectCCDS26628.1
International Mouse Knockout Project StatusIrx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036811 VEGA Gene Model | MGI Sequence Detail 5379 C57BL/6J ±  kb
transcript OTTMUST00000094478 VEGA | MGI Sequence Detail 2625 Not Applicable 
polypeptide OTTMUSP00000052558 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003893 Iroquois-class homeodomain protein
Protein Ontology PR:000032600 iroquois-class homeodomain protein IRX-2
References (Earliest) J:45683 Bosse A, et al., Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 1997 Dec;69(1-2):169-81
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(68)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory