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Irx2
Gene Detail
 Symbol
Name
ID
Irx2
Iroquois related homeobox 2 (Drosophila)
MGI:1197526
Synonyms IRX6
Feature Type protein coding gene
Genetic Map
Chromosome 13
39.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:72628820-72634196 bp, + strand
From VEGA annotation of GRCm38

  5377 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Irx2

Human
homologs
Human Homolog IRX2, iroquois homeobox 2
NCBI Gene ID 153572
neXtProt AC  NX_Q9BZI1
Human Synonyms  IRXA2
Human Chr (Location)  5p15.33; chr5:2746165-2751655 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene are phenotypically normal.
 
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process regulation of transcription, DNA-templated
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (516)    Tissues (254)    Images (86)
Theiler Stages: 2, 3, 9, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 468
Northern blot 1
RT-PCR 47
cDNA source data(122)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(127) cDNA(122) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036811 (Evidence)
Ensembl Gene ModelENSMUSG00000001504 (Evidence)
Entrez Gene16372 (Evidence)
UniGene28888
DFCITC1577611, TC1587352, TC1644118
DoTSDT.110962466, DT.530785, DT.91444645
NIA Mouse Gene IndexU014992
Consensus CDS ProjectCCDS26628.1
International Mouse Knockout Project StatusIrx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036811 VEGA Gene Model | MGI Sequence Detail 5377 C57BL/6J ±  kb
transcript OTTMUST00000094478 VEGA | MGI Sequence Detail 2623 Not Applicable 
polypeptide OTTMUSP00000052558 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003893 Iroquois-class homeodomain protein
Protein Ontology PR:000032600 iroquois-class homeodomain protein IRX-2
References (Earliest) J:45683 Bosse A, et al., Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 1997 Dec;69(1-2):169-81
(Latest) J:194051 Heliot C, et al., HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2. Development. 2013 Feb;140(4):873-85
All references(67)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory