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Irx2
Gene Detail
Symbol

Name
ID
Irx2
Iroquois related homeobox 2 (Drosophila)
MGI:1197526
Synonyms
IRX6
Feature Type
protein coding gene
Genetic Map
Chromosome 13
39.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:72628797-72634198 bp, + strand
From VEGA annotation of GRCm38

  5402 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IRX2
Gene Tree: Irx2

Human
homologs
IRX2, iroquois homeobox 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 153572
neXtProt AC: NX_Q9BZI1

Human Synonyms: IRXA2

Human Chr (Location): 5p15.33; chr5:2741863-2751655 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene are phenotypically normal.
 
Interactions
Irx2 interacts with 204 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process regulation of transcription, DNA-templated
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (516)    Tissues (255)    Images (86)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 468
Northern blot 1
RT-PCR 47
cDNA source data(122)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA IRX2 ; Xenbase irx2 ; ZFIN irx2a    NEW 
Molecular
reagents
All nucleic(127) cDNA(122) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000036811 (Evidence)
Ensembl Gene Model ENSMUSG00000001504 (Evidence)
Entrez Gene 16372 (Evidence)
UniGene 28888
DFCI TC1577611, TC1587352, TC1644118
DoTS DT.110962466, DT.530785, DT.91444645
NIA Mouse Gene Index U014992
Consensus CDS Project CCDS26628.1
International Mouse Phenotyping Consortium Status Irx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036811 VEGA Gene Model | MGI Sequence Detail 5402 C57BL/6J ±  kb
transcript OTTMUST00000094478 VEGA | MGI Sequence Detail 2625 Not Applicable 
polypeptide OTTMUSP00000052558 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003893 Iroquois-class homeodomain protein
Protein Ontology PR:000032600 iroquois-class homeodomain protein IRX-2
References
(Earliest) J:45683 Bosse A, et al., Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 1997 Dec;69(1-2):169-81
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(66)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory