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Irx2 Gene Detail
Summary
  • Symbol
    Irx2
  • Name
    Iroquois homeobox 2
  • Synonyms
    IRX6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197526
    NCBI Gene: 16372
  • Gene Overview
    MyGene.info: IRX2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:72628820-72634198 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 39.23 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197526
protein coding gene Chr13:72628797-72634198 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020740
protein coding gene Chr13:73021975-73028926 (+)
A/J MGP_AJ_G0020696
protein coding gene Chr13:70444716-70450097 (+)
AKR/J MGP_AKRJ_G0020671
protein coding gene Chr13:72659173-72665877 (+)
BALB/cJ MGP_BALBcJ_G0020693
protein coding gene Chr13:70940170-70947268 (+)
C3H/HeJ MGP_C3HHeJ_G0020488
protein coding gene Chr13:72363552-72368908 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021130
protein coding gene Chr13:75508005-75515342 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018698
protein coding gene Chr13:67246013-67251362 (+)
CAST/EiJ MGP_CASTEiJ_G0020005
protein coding gene Chr13:71405070-71421903 (+)
CBA/J MGP_CBAJ_G0020446
protein coding gene Chr13:78329421-78334777 (+)
DBA/2J MGP_DBA2J_G0020572
protein coding gene Chr13:70269845-70275200 (+)
FVB/NJ MGP_FVBNJ_G0020552
protein coding gene Chr13:69293555-69299297 (+)
LP/J MGP_LPJ_G0020644
protein coding gene Chr13:73277928-73284436 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020580
protein coding gene Chr13:76778138-76784324 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021169
protein coding gene Chr13:71955171-71960843 (+)
PWK/PhJ MGP_PWKPhJ_G0019759
protein coding gene Chr13:68986628-69003543 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019582
protein coding gene Chr13:68432072-68437423 (+)
WSB/EiJ MGP_WSBEiJ_G0020062
protein coding gene Chr13:72496915-72504018 (+)



Homology
more
  • Human Ortholog
    IRX2, iroquois homeobox 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IRX2, iroquois homeobox 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IRXA2
  • Links
    NCBI Gene ID: 153572
    neXtProt AC: NX_Q9BZI1
    UniProt: Q9BZI1

  • Chr Location
    5p15.33; chr5:2707930-2751655 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for disruptions in this gene are phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001504 Ensembl Gene Model | MGI Sequence Detail 5379 C57BL/6J ±  kb
transcript ENSMUST00000074372 Ensembl | MGI Sequence Detail 2625 Not Applicable  
polypeptide ENSMUSP00000073976 Ensembl | MGI Sequence Detail 474 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 129
    cDNA 124
    Primer pair 4
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 79
    Developmental Gene Expression 48
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:260112 Filipova D, et al., Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5. PLoS One. 2018;13(3):e0194428

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support.
last database update
11/27/2018
MGI 6.13
The Jackson Laboratory