Aatk
Gene Detail

Symbol Name ID

Aatk apoptosis-associated tyrosine kinase MGI:1197518

Synonyms

AATYK1, mKIAA0641

Feature Type

protein coding gene

Genetic Map

Chromosome 11

83.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:120007313-120047167 bp, - strand From VEGA annotation of GRCm38   39855 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74861  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Aatk

Human homologs

Human Homolog		AATK, apoptosis-associated tyrosine kinase
NCBI Gene ID		9625
neXtProt AC		NX_Q6ZMQ8
Human Synonyms		AATYK, AATYK1, LMR1, LMTK1, p35BP
Human Chr (Location)		17q25.3; chr17:79091095-79139872 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit decreased brain size, longer axons and fewer neurites.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	apoptotic process, brain development, ...
Component	axonal growth cone, cell projection, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(55) cDNA(55)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000004053 (Evidence)
Ensembl Gene Model	ENSMUSG00000025375 (Evidence)
Entrez Gene	11302 (Evidence)
UniGene	6826
DFCI	TC1577312, TC1597020
DoTS	DT.101389738, DT.101389740, DT.110517481, DT.40156960, DT.526590
NIA Mouse Gene Index	U033703
EC	2.7.11.1
Consensus CDS Project	CCDS25725.1, CCDS56826.1
International Mouse Knockout Project Status	Aatk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004053	VEGA Gene Model | MGI Sequence Detail	39855	C57BL/6J
transcript	OTTMUST00000009038	VEGA | MGI Sequence Detail	5336	Not Applicable
polypeptide	OTTMUSP00000004390	VEGA | MGI Sequence Detail	1374	Not Applicable

All sequences(58) RefSeq(6) UniProt(4)

Polymorphisms

SNPs(140 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
Protein Ontology	PR:000003535	serine/threonine-protein kinase LMTK1

References

(Earliest) J:45453 Gaozza E, et al., AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells. Oncogene. 1997 Dec 18;15(25):3127-35
(Latest) J:184851 Takano T, et al., LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner. J Neurosci. 2012 May 9;32(19):6587-99
All references(36)