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Aatk
Gene Detail
 Symbol
Name
ID
Aatk
apoptosis-associated tyrosine kinase
MGI:1197518
Synonyms AATYK1, mKIAA0641
Feature Type protein coding gene
Genetic Map
Chromosome 11
83.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:120007313-120047167 bp, - strand
From VEGA annotation of GRCm38

  39855 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74861  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Aatk

Human
homologs
Human Homolog AATK, apoptosis-associated tyrosine kinase
NCBI Gene ID 9625
neXtProt AC  NX_Q6ZMQ8
Human Synonyms  AATYK, AATYK1, LMR1, LMTK1, p35BP, PPP1R77
Human Chr (Location)  17q25.3; chr17:81117295-81166072 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased brain size, longer axons and fewer neurites.
 
Interactions
Aatk interacts with 170 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process apoptotic process, brain development, ...
Component axonal growth cone, cell projection, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(55)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) cDNA(55)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000004053 (Evidence)
Ensembl Gene ModelENSMUSG00000025375 (Evidence)
Entrez Gene11302 (Evidence)
UniGene6826
DFCITC1577312, TC1597020
DoTSDT.101389738, DT.101389740, DT.110517481, DT.40156960, DT.526590
NIA Mouse Gene IndexU033703
EC2.7.11.1
Consensus CDS ProjectCCDS25725.1, CCDS56826.1
International Mouse Knockout Project StatusAatk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004053 VEGA Gene Model | MGI Sequence Detail 39855 C57BL/6J ±  kb
transcript OTTMUST00000009038 VEGA | MGI Sequence Detail 5336 Not Applicable 
polypeptide OTTMUSP00000004390 VEGA | MGI Sequence Detail 1374 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(17) UniProt(3)
Polymorphisms SNPs within 2kb(154 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
Protein Ontology PR:000003535 serine/threonine-protein kinase LMTK1
References (Earliest) J:45453 Gaozza E, et al., AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells. Oncogene. 1997 Dec 18;15(25):3127-35
(Latest) J:184851 Takano T, et al., LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner. J Neurosci. 2012 May 9;32(19):6587-99
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory