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Aatk Gene Detail
Summary
  • Symbol
    Aatk
  • Name
    apoptosis-associated tyrosine kinase
  • Synonyms
    AATYK1, mKIAA0641
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197518
    NCBI Gene: 11302
  • Gene Overview
    MyGene.info: AATK
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:120007313-120047167 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39855 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.96 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    AATK, apoptosis associated tyrosine kinase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    AATK, apoptosis associated tyrosine kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AATYK, AATYK1, LMR1, LMTK1, p35BP, PPP1R77
  • Links
    NCBI Gene ID: 9625
    neXtProt AC: NX_Q6ZMQ8
    UniProt: Q6ZMQ8

  • Chr Location
    17q25.3; chr17:81117295-81166072 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74861
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AATK
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased brain size, longer axons and fewer neurites.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000004053 VEGA Gene Model | MGI Sequence Detail 39855 C57BL/6J ±  kb
    transcript OTTMUST00000009038 VEGA | MGI Sequence Detail 5336 Not Applicable  
    polypeptide OTTMUSP00000004390 VEGA | MGI Sequence Detail 1374 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      153 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
    Molecular
    Reagents
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    • All nucleic 56
      cDNA 56

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 4
    • Earliest
      J:45453 Gaozza E, et al., AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells. Oncogene. 1997 Dec 18;15(25):3127-35
    • Latest
      J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory