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Aatk Gene Detail
Summary
  • Symbol
    Aatk
  • Name
    apoptosis-associated tyrosine kinase
  • Synonyms
    AATYK1, mKIAA0641
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197518
    NCBI Gene: 11302
  • Gene Overview
    MyGene.info: AATK
Location & Maps
more
  • Sequence Map
    Chr11:120007313-120047167 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39855 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.96 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    AATK, apoptosis associated tyrosine kinase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    AATK, apoptosis associated tyrosine kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AATYK, AATYK1, LMR1, LMTK1, p35BP, PPP1R77
  • Links
    NCBI Gene ID: 9625
    neXtProt AC: NX_Q6ZMQ8

  • Chr Location
    17q25.3; chr17:81117295-81166072 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 74861
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: AATK
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased brain size, longer axons and fewer neurites.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004053 VEGA Gene Model | MGI Sequence Detail 39855 C57BL/6J ±  kb
transcript OTTMUST00000009038 VEGA | MGI Sequence Detail 5336 Not Applicable  
polypeptide OTTMUSP00000004390 VEGA | MGI Sequence Detail 1374 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    153 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003535 serine/threonine-protein kinase LMTK1
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 55
    cDNA 55

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 4
  • Earliest
    J:45453 Gaozza E, et al., AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells. Oncogene. 1997 Dec 18;15(25):3127-35
  • Latest
    J:208141 Ma S, et al., Apoptosis-associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma. Lab Invest. 2014 Apr;94(4):430-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory