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Limk2
Gene Detail
Symbol

Name
ID
Limk2
LIM motif-containing protein kinase 2
MGI:1197517
Synonyms
A930024P04Rik, Limk2a, Limk2b, LIM kinase 2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
2.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:3344256-3409189 bp, - strand
From VEGA annotation of GRCm38

  64934 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55911  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LIMK2
Protein SuperFamily: LIM protein kinase
Gene Tree: Limk2

Human
homologs
LIMK2, LIM domain kinase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3985
neXtProt AC: NX_P53671

Human Chr (Location): 22q12.2; chr22:31212264-31280080 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(108) : Gene trapped(105) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Male homozygotes for targeted null mutations exhibit small testes but are fertile. Mutant kidneys have fewer glomeruli and dilated renal tubules, but function normally. Mice homozygous for a gene trap allele exhibit open eyelids at birth.
 
Phenotype Images(2)
Interactions
Limk2 interacts with 238 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process phosphorylation, protein phosphorylation, ...
Component cis-Golgi network, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (193)    Tissues (71)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 151
Northern blot 24
Western blot 8
RT-PCR 10
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase limk2 ; ZFIN limk2    NEW 
Molecular
reagents
All nucleic(33) Genomic(7) cDNA(22) Primer pair(3) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000000764 (Evidence)
Ensembl Gene Model ENSMUSG00000020451 (Evidence)
Entrez Gene 16886 (Evidence)
DFCI TC1646114, TC1611209, TC1597705, TC1572385
EC 2.7.11.1
PDB 2YUB
Consensus CDS Project CCDS24358.1, CCDS24359.1, CCDS24360.1
International Mouse Phenotyping Consortium Status Limk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000764 VEGA Gene Model | MGI Sequence Detail 64934 C57BL/6J ±  kb
transcript OTTMUST00000011177 VEGA | MGI Sequence Detail 3514 Not Applicable 
polypeptide OTTMUSP00000005213 VEGA | MGI Sequence Detail 638 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(16) UniProt(4)
Polymorphisms
SNPs within 2kb(209 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016253 Integrin-linked protein kinase
InterPro IPR001478 PDZ domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009817 LIM domain kinase 2
References
(Earliest) J:44929 Koshimizu U, et al., cDNA cloning, genomic organization, and chromosomal localization of the mouse LIM motif-containing kinase gene, Limk2. Biochem Biophys Res Commun. 1997 Dec 18;241(2):243-50
(Latest) J:195280 Andrews WD, et al., Limk2 mediates semaphorin signalling in cortical interneurons migrating through the subpallium. Biol Open. 2013 Mar 15;2(3):277-82
All references(52)
Other
accession IDs
MGI:2144678, MGI:2443338

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory