Wnt9b
Gene Detail

Symbol Name ID

Wnt9b wingless-type MMTV integration site 9B MGI:1197020

Synonyms

clf, clf1, Wnt14b, Wnt15

Feature Type

protein coding gene

Genetic Map

Chromosome 11

67.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr11:103727364-103749821 bp, - strand From VEGA annotation of GRCm38   22458 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt9b

Human homologs

Human Homolog		WNT9B, wingless-type MMTV integration site family, member 9B
NCBI Gene ID		7484
neXtProt AC		NX_O14905
Human Synonyms		WNT14B, WNT15
Human Chr (Location)		17q21; chr17:44928968-44954437 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Spontaneous(1)
 

Homozygous null mice display neonatal lethality, disrupted ureteric bud branching, impaired Mullerian duct formation, and incompletely penetrant cleft lip and palate. In mice with alleles that decrease expression kidneys are smaller with fewer mature nephrons.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	branching involved in ureteric bud morphogenesis, branching morphogenesis of an epithelial tube, ...
Component	extracellular region, extracellular space, ...
Function	frizzled binding, receptor binding

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (68 records)
Data Summary: Results (218)    Tissues (189)    Images (29)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 10, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	172
RT-PCR	44
RNase protection	2

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(5) cDNA(16) Primer pair(10) Other(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000003017 (Evidence)
Ensembl Gene Model	ENSMUSG00000018486 (Evidence)
Entrez Gene	22412 (Evidence)
UniGene	215161
DFCI	TC1588043, TC1642958
DoTS	DT.87057942
Consensus CDS Project	CCDS25522.1
International Mouse Knockout Project Status	Wnt9b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003017	VEGA Gene Model | MGI Sequence Detail	22458	C57BL/6J
transcript	OTTMUST00000006192	VEGA | MGI Sequence Detail	4518	Not Applicable
polypeptide	OTTMUSP00000002922	VEGA | MGI Sequence Detail	359	Not Applicable

All sequences(22) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs(131 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR026535	Wnt-9 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017453	protein Wnt-9b

References

(Earliest) J:8487 Biddle FG, et al., Major gene determination of liability to spontaneous cleft lip in the mouse. J Craniofac Genet Dev Biol Suppl. 1986;2:67-88
(Latest) J:194050 Massa F, et al., Hepatocyte nuclear factor 1beta controls nephron tubular development. Development. 2013 Feb;140(4):886-96
All references(117)

Other accession IDs

MGD-MRK-16443, MGD-MRK-2011, MGI:99658