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Wnt9b Gene Detail
Summary
  • Symbol
    Wnt9b
  • Name
    wingless-type MMTV integration site family, member 9B
  • Synonyms
    clf, clf1, Wnt14b, Wnt15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197020
    NCBI Gene: 22412
  • Gene Overview
    MyGene.info: WNT9B
Location & Maps
more
  • Sequence Map
    Chr11:103727364-103749821 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22458 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 67.47 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    WNT9B, Wnt family member 9B
  • Vertebrate Orthologs
    11
  • Human Ortholog
    WNT9B, Wnt family member 9B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    WNT14B, WNT15
  • Links
    NCBI Gene ID: 7484
    neXtProt AC: NX_O14905

  • Chr Location
    17q21.32; chr17:46833201-46886775 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 4 alleles in 7 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Wnt9b
  • Incidental Mutations
    APF
Homozygous null mice display neonatal lethality, disrupted ureteric bud branching, impaired Mullerian duct formation, and incompletely penetrant cleft lip and palate. In mice with alleles that decrease expression kidneys are smaller with fewer mature nephrons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003017 VEGA Gene Model | MGI Sequence Detail 22458 C57BL/6J ±  kb
transcript OTTMUST00000006192 VEGA | MGI Sequence Detail 4518 Not Applicable  
polypeptide OTTMUSP00000002922 VEGA | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    136 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 36
    Genomic 5
    cDNA 18
    Primer pair 10
    Other 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-16443, MGD-MRK-2011, MGI:99658
References
more
  • Summaries
    All 138
    Developmental Gene Expression 89
    Gene Ontology 11
    Phenotypes 25
  • Earliest
    J:8487 Biddle FG, et al., Major gene determination of liability to spontaneous cleft lip in the mouse. J Craniofac Genet Dev Biol Suppl. 1986;2:67-88
  • Latest
    J:229317 Zhu XJ, et al., Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis. Dev Dyn. 2016 Mar;245(3):414-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory