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Daxx
Gene Detail
 Symbol
Name
ID
Daxx
Fas death domain-associated protein
MGI:1197015
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:33909414-33915589 bp, + strand
From VEGA annotation of GRCm38

  6176 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1033  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Daxx

Human
homologs
Human Homolog DAXX, death-domain associated protein
NCBI Gene ID 1616
neXtProt AC  NX_Q9UER7
Human Synonyms  BING2, DAP6, EAP1
Human Chr (Location)  6p21.3; chr6:33318558-33323016 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(13) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation of this gene display extensive apoptosis and embryonic lethality.
 
Interactions
Daxx interacts with 37 markers (Mir28b, Mir28c, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process androgen receptor signaling pathway, apoptotic process, ...
Component cell body, cell cortex, ...
Function androgen receptor binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (33)    Tissues (24)    Images (2)
Theiler Stages: 9, 16, 23, 28
Assay TypeResults
RNA in situ 24
RT-PCR 9
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(14) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037068 (Evidence)
Ensembl Gene ModelENSMUSG00000002307 (Evidence)
Entrez Gene13163 (Evidence)
DFCITC1575092, TC1687345, TC1692898
DoTSDT.101221619, DT.101713700, DT.103586800, DT.488171, DT.55243907
NIA Mouse Gene IndexU017831
Consensus CDS ProjectCCDS28633.1
International Mouse Knockout Project StatusDaxx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037068 VEGA Gene Model | MGI Sequence Detail 6176 C57BL/6J ±  kb
transcript OTTMUST00000095360 VEGA | MGI Sequence Detail 2580 Not Applicable 
polypeptide OTTMUSP00000053214 VEGA | MGI Sequence Detail 740 Not Applicable 

For the selected sequences
All sequences(117) RefSeq(32) UniProt(17)
Polymorphisms RFLP(1) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR005012 Daxx protein
Protein Ontology PR:000006283 death domain-associated protein 6
References (Earliest) J:41242 Yang X, et al., Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 1997 Jun 27;89(7):1067-76
(Latest) J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
All references(61)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory