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Daxx Gene Detail
Summary
  • Symbol
    Daxx
  • Name
    Fas death domain-associated protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197015
    NCBI Gene: 13163
  • Gene Overview
    MyGene.info: DAXX
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:33909414-33915589 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6176 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    DAXX, death domain associated protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DAXX, death domain associated protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BING2, DAP6, EAP1
  • Links
    NCBI Gene ID: 1616
    neXtProt AC: NX_Q9UER7
    UniProt: Q9UER7

  • Chr Location
    6p21.32; chr6:33318558-33323016 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation of this gene display extensive apoptosis and embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037068 VEGA Gene Model | MGI Sequence Detail 6176 C57BL/6J ±  kb
    transcript OTTMUST00000095360 VEGA | MGI Sequence Detail 2580 Not Applicable  
    polypeptide OTTMUSP00000053214 VEGA | MGI Sequence Detail 740 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • RFLP
    Protein
    Information
    less
    • UniProt
      18 Sequences
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR038298 Daxx, N-terminal domain superfamily
      IPR031333 Daxx, N-terminal Rassf1C-interacting domain
      IPR005012 Daxx protein
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 2
      cDNA 15
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 5
      Gene Ontology 20
      Phenotypes 11
    • Earliest
      J:41242 Yang X, et al., Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 1997 Jun 27;89(7):1067-76
    • Latest
      J:248495 Li J, et al., Daxx plays a novel role in T cell survival but is dispensable in Fas-induced apoptosis. PLoS One. 2017;12(3):e0174011

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory