Daxx
Gene Detail

Symbol Name ID

Daxx Fas death domain-associated protein MGI:1197015

Feature Type

protein coding gene

Genetic Map

Chromosome 17

17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr17:33909414-33915589 bp, + strand From VEGA annotation of GRCm38   6176 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1033  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Daxx

Human homologs

Human Homolog		DAXX, death-domain associated protein
NCBI Gene ID		1616
neXtProt AC		NX_Q9UER7
Human Synonyms		BING2, DAP6, EAP1
Human Chr (Location)		6p21.3; chr6:33286335-33290793 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(16) : Targeted(3) Gene trapped(13)
 

Mice homozygous for a targeted mutation of this gene display extensive apoptosis and embryonic lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	androgen receptor signaling pathway, apoptotic process, ...
Component	cell body, cell cortex, ...
Function	androgen receptor binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (33)    Tissues (24)    Images (2)
Theiler Stages: 9, 16, 23, 28

Assay Type	Results
RNA in situ	24
RT-PCR	9

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(2) cDNA(14) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037068 (Evidence)
Ensembl Gene Model	ENSMUSG00000002307 (Evidence)
Entrez Gene	13163 (Evidence)
DFCI	TC1575092, TC1687345, TC1692898
DoTS	DT.101221619, DT.101713700, DT.103586800, DT.488171, DT.55243907
NIA Mouse Gene Index	U017831
Consensus CDS Project	CCDS28633.1
International Mouse Knockout Project Status	Daxx

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037068	VEGA Gene Model | MGI Sequence Detail	6176	C57BL/6J
transcript	OTTMUST00000095360	VEGA | MGI Sequence Detail	2580	Not Applicable
polypeptide	OTTMUSP00000053214	VEGA | MGI Sequence Detail	740	Not Applicable

All sequences(88) RefSeq(4) UniProt(17)

Polymorphisms

RFLP(1) : SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR005012	Daxx protein
Protein Ontology	PR:000006283	death domain-associated protein 6

References

(Earliest) J:41242 Yang X, et al., Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 1997 Jun 27;89(7):1067-76
(Latest) J:188393 Michod D, et al., Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation. Neuron. 2012 Apr 12;74(1):122-35
All references(57)