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Daxx Gene Detail
Summary
  • Symbol
    Daxx
  • Name
    Fas death domain-associated protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197015
    NCBI Gene: 13163
  • Gene Overview
    MyGene.info: DAXX
Location & Maps
more
  • Sequence Map
    Chr17:33909414-33915589 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6176 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    DAXX, death domain associated protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DAXX, death domain associated protein
    Orthology source: HomoloGene
  • Synonyms
    BING2, DAP6, EAP1
  • Links
    NCBI Gene ID: 1616
    neXtProt AC: NX_Q9UER7

  • Chr Location
    6p21.3; chr6:33318558-33323016 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation of this gene display extensive apoptosis and embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037068 VEGA Gene Model | MGI Sequence Detail 6176 C57BL/6J ±  kb
transcript OTTMUST00000095360 VEGA | MGI Sequence Detail 2580 Not Applicable  
polypeptide OTTMUSP00000053214 VEGA | MGI Sequence Detail 740 Not Applicable  
For the selected sequence
Polymorphisms
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  • RFLP
Protein
Information
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  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000006283 death domain-associated protein 6
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR031333 Daxx, N-terminal Rassf1C-interacting domain
    IPR005012 Daxx protein
Molecular
Reagents
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  • All nucleic 17
    Genomic 2
    cDNA 14
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 60
    Developmental Gene Expression 5
    Gene Ontology 17
    Phenotypes 10
  • Earliest
    J:41242 Yang X, et al., Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 1997 Jun 27;89(7):1067-76
  • Latest
    J:212987 Yao Z, et al., Death domain-associated protein 6 (Daxx) selectively represses IL-6 transcription through histone deacetylase 1 (HDAC1)-mediated histone deacetylation in macrophages. J Biol Chem. 2014 Mar 28;289(13):9372-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory