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Daxx Gene Detail
Summary
  • Symbol
    Daxx
  • Name
    Fas death domain-associated protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197015
    NCBI Gene: 13163
  • Gene Overview
    MyGene.info: DAXX
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:33909414-33915589 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197015
protein coding gene Chr17:33909381-33915590 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023541
protein coding gene Chr17:33858826-33864855 (+)
A/J MGP_AJ_G0023502
protein coding gene Chr17:32691972-32698110 (+)
AKR/J MGP_AKRJ_G0023468
protein coding gene Chr17:33087620-33093767 (+)
BALB/cJ MGP_BALBcJ_G0023505
protein coding gene Chr17:32864911-32871066 (+)
C3H/HeJ MGP_C3HHeJ_G0023267
protein coding gene Chr17:33443056-33449125 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023812
protein coding gene Chr17:27180036-27189334 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021421
protein coding gene Chr17:30194332-30200302 (+)
CAST/EiJ MGP_CASTEiJ_G0022769
protein coding gene Chr17:33513465-33520275 (+)
CBA/J MGP_CBAJ_G0023244
protein coding gene Chr17:36540947-36547206 (+)
DBA/2J MGP_DBA2J_G0023372
protein coding gene Chr17:32069394-32075688 (+)
FVB/NJ MGP_FVBNJ_G0023341
protein coding gene Chr17:31928816-31934949 (+)
LP/J MGP_LPJ_G0023450
protein coding gene Chr17:34133195-34139580 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023363
protein coding gene Chr17:35593465-35599598 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023988
protein coding gene Chr17:33411560-33419846 (+)
PWK/PhJ MGP_PWKPhJ_G0022517
protein coding gene Chr17:30982200-30988902 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022333
protein coding gene Chr17:31370896-31382017 (+)
WSB/EiJ MGP_WSBEiJ_G0022829
protein coding gene Chr17:33453752-33459887 (+)



Homology
more
  • Human Ortholog
    DAXX, death domain associated protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DAXX, death domain associated protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BING2, DAP6, EAP1
  • Links
    NCBI Gene ID: 1616
    neXtProt AC: NX_Q9UER7
    UniProt: Q9UER7

  • Chr Location
    6p21.32; chr6:33318558-33323016 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation of this gene display extensive apoptosis and embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002307 Ensembl Gene Model | MGI Sequence Detail 6176 C57BL/6J ±  kb
    transcript ENSMUST00000079421 Ensembl | MGI Sequence Detail 2580 Not Applicable  
    polypeptide ENSMUSP00000078390 Ensembl | MGI Sequence Detail 740 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      18 Sequences
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR038298 Daxx, N-terminal domain superfamily
      IPR031333 Daxx, N-terminal Rassf1C-interacting domain
      IPR005012 Daxx protein
    Molecular
    Reagents
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    • All nucleic 19
      Genomic 2
      cDNA 16
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 5
      Gene Ontology 20
      Phenotypes 11
    • Earliest
      J:41242 Yang X, et al., Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 1997 Jun 27;89(7):1067-76
    • Latest
      J:248495 Li J, et al., Daxx plays a novel role in T cell survival but is dispensable in Fas-induced apoptosis. PLoS One. 2017;12(3):e0174011

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory