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Rasa3 Gene Detail
Summary
  • Symbol
    Rasa3
  • Name
    RAS p21 protein activator 3
  • Synonyms
    GAPIII, GAPIII activator 3, hlb381, Ras GTPase-activating protein III, R-Ras gap, scat
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197013
    NCBI Gene: 19414
  • Gene Overview
    MyGene.info: RASA3
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:13567218-13677587 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 6.29 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197013
protein coding gene Chr8:13566948-13677603 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033384
protein coding gene Chr8:10925223-11046681 (-)
A/J MGP_AJ_G0033364
protein coding gene Chr8:10528771-10639102 (-)
AKR/J MGP_AKRJ_G0033295
protein coding gene Chr8:10814874-10928185 (-)
BALB/cJ MGP_BALBcJ_G0033365
protein coding gene Chr8:10661264-10771021 (-)
C3H/HeJ MGP_C3HHeJ_G0033078
protein coding gene Chr8:11031839-11142309 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033877
protein coding gene Chr8:11299859-11412740 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030845
protein coding gene Chr8:10029298-10140715 (-)
CAST/EiJ MGP_CASTEiJ_G0032400
protein coding gene Chr8:10787262-10911604 (-)
CBA/J MGP_CBAJ_G0033051
protein coding gene Chr8:11776834-11901519 (-)
DBA/2J MGP_DBA2J_G0033204
protein coding gene Chr8:10474235-10586251 (-)
FVB/NJ MGP_FVBNJ_G0033153
protein coding gene Chr8:10490465-10607766 (-)
LP/J MGP_LPJ_G0033298
protein coding gene Chr8:10850825-10974413 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033187
protein coding gene Chr8:11994288-12109170 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033894
protein coding gene Chr8:10875978-10985608 (-)
PWK/PhJ MGP_PWKPhJ_G0032113
protein coding gene Chr8:10533369-10646292 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031955
protein coding gene Chr8:10768864-10885176 (-)
WSB/EiJ MGP_WSBEiJ_G0032516
protein coding gene Chr8:10912781-11026172 (-)



Homology
more
  • Human Ortholog
    RASA3, RAS p21 protein activator 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RASA3, RAS p21 protein activator 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GAP1IP4BP, GAPIII
  • Links
    NCBI Gene ID: 22821
    neXtProt AC: NX_Q14644
    UniProt: Q14644

  • Chr Location
    13q34; chr13:113977783-114132623 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7217
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RASA3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation die at E12.5-13.5 of massive subcutaneous and intraparenchymal hemorrhage, probably due to underdeveloped adherens junctions between capillary endothelial cells. At E12.5, edema and severe hemorrhaging is frequently observed in the brain and/or rump.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19414 NCBI Gene Model | MGI Sequence Detail 110370 C57BL/6J ±  kb
    transcript NM_009025 RefSeq | MGI Sequence Detail 4118 C57BL/6  
    polypeptide Q60790 UniProt | EBI | MGI Sequence Detail 834 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 124
      cDNA 122
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14301, MGI:2142514, MGI:2142874, MGI:3575138, MGI:98236
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:10670 Peters LL, et al., Heritable severe combined anemia and thrombocytopenia in the mouse: description of the disease and successful therapy. Blood. 1990 Aug 15;76(4):745-54
    • Latest
      J:257738 Molina-Ortiz P, et al., Rasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism. PLoS Genet. 2018 Jan;14(1):e1007195

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory