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Rasa3 Gene Detail
Summary
  • Symbol
    Rasa3
  • Name
    RAS p21 protein activator 3
  • Synonyms
    GAPIII, GAPIII activator 3, hlb381, Ras GTPase-activating protein III, R-Ras gap, scat
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197013
    NCBI Gene: 19414
  • Gene Overview
    MyGene.info: RASA3
Location & Maps
more
  • Sequence Map
    Chr8:13566948-13677603 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      110656 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 6.29 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    RASA3, RAS p21 protein activator 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RASA3, RAS p21 protein activator 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GAP1IP4BP, GAPIII
  • Links
    NCBI Gene ID: 22821
    neXtProt AC: NX_Q14644

  • Chr Location
    13q34; chr13:113977783-114132620 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7217
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RASA3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Spontaneous
    1
  • Targeted
    6
  • Incidental Mutations
Mice homozygous for a targeted null mutation die at E12.5-13.5 of massive subcutaneous and intraparenchymal hemorrhage, probably due to underdeveloped adherens junctions between capillary endothelial cells. At E12.5, edema and severe hemorrhaging is frequently observed in the brain and/or rump.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029877 VEGA Gene Model | MGI Sequence Detail 110656 C57BL/6J ±  kb
transcript OTTMUST00000074137 VEGA | MGI Sequence Detail 4404 Not Applicable  
polypeptide OTTMUSP00000038486 VEGA | MGI Sequence Detail 834 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1216 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 123
    cDNA 121
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-14301, MGI:2142514, MGI:2142874, MGI:3575138, MGI:98236
References
more
  • Summaries
    All 54
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:10670 Peters LL, et al., Heritable severe combined anemia and thrombocytopenia in the mouse: description of the disease and successful therapy. Blood. 1990 Aug 15;76(4):745-54
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory