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Rasa3
Gene Detail
Symbol

Name
ID
Rasa3
RAS p21 protein activator 3
MGI:1197013
Synonyms
GAPIII, GAPIII activator 3, Ras GTPase-activating protein III, R-Ras gap, scat
Feature Type
protein coding gene
Genetic Map
Chromosome 8
6.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:13566950-13677603 bp, - strand
From VEGA annotation of GRCm38

  110654 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7217  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RASA3
Gene Tree: Rasa3

Human
homologs
RASA3, RAS p21 protein activator 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 22821
neXtProt AC: NX_Q14644

Human Synonyms: GAP1IP4BP, GAPIII

Human Chr (Location): 13q34; chr13:113977783-114132620 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null mutation die at E12.5-13.5 of massive subcutaneous and intraparenchymal hemorrhage, probably due to underdeveloped adherens junctions between capillary endothelial cells. At E12.5, edema and severe hemorrhaging is frequently observed in the brain and/or rump.
 
Phenotype Images(1)
Interactions
Rasa3 interacts with 204 markers (Mir1a-1, Mir1a-2, Mir24-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (173)    Tissues (28)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 171
RT-PCR 2
cDNA source data(120)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase rasa3 ; ZFIN rasa3    NEW 
Molecular
reagents
All nucleic(123) cDNA(121) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029877 (Evidence)
Ensembl Gene Model ENSMUSG00000031453 (Evidence)
Entrez Gene 19414 (Evidence)
UniGene 18517
DFCI TC1572535, TC1591996, TC1640983
DoTS DT.101319334, DT.101736381, DT.493613
NIA Mouse Gene Index U029604
Consensus CDS Project CCDS40234.1
International Mouse Phenotyping Consortium Status Rasa3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029877 VEGA Gene Model | MGI Sequence Detail 110654 C57BL/6J ±  kb
transcript OTTMUST00000074137 VEGA | MGI Sequence Detail 4402 Not Applicable 
polypeptide OTTMUSP00000038486 VEGA | MGI Sequence Detail 834 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(1217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
InterPro IPR001936 Ras GTPase-activating protein
InterPro IPR023152 Ras GTPase-activating protein, conserved site
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001562 Zinc finger, Btk motif
Protein Ontology PR:000013745 ras GTPase-activating protein 3
References
(Earliest) J:10670 Peters LL, et al., Heritable severe combined anemia and thrombocytopenia in the mouse: description of the disease and successful therapy. Blood. 1990 Aug 15;76(4):745-54
(Latest) J:221899 Stefanini L, et al., RASA3 is a critical inhibitor of RAP1-dependent platelet activation. J Clin Invest. 2015 Apr;125(4):1419-32
All references(54)
Other
accession IDs
MGD-MRK-14301, MGI:2142514, MGI:2142874, MGI:98236

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory