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Rasa3 Gene Detail
Summary
  • Symbol
    Rasa3
  • Name
    RAS p21 protein activator 3
  • Synonyms
    GAPIII, GAPIII activator 3, hlb381, Ras GTPase-activating protein III, R-Ras gap, scat
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197013
    NCBI Gene: 19414
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:13617218-13727590 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 6.29 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3472 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197013
 protein coding gene Chr8:13616948-13727603 (-)
129S1/SvImJ ENSMUSG00200030551
 protein coding gene Chr8:10510348-10620989 (-)
A/J ENSMUSG00195038305
 protein coding gene Chr8:10860184-10970821 (-)
AKR/J ENSMUSG00220028911
 protein coding gene Chr8:10589459-10700082 (-)
BALB/cJ ENSMUSG00180021086
 protein coding gene Chr8:10499302-10609933 (-)
C3H/HeJ ENSMUSG00175035288
 protein coding gene Chr8:10659111-10769742 (-)
C57BL/6NJ ENSMUSG00215017405
 protein coding gene Chr8:10533453-10644093 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030845
 protein coding gene Chr8:10029298-10140715 (-)
CAST/EiJ ENSTCUG00005018337
 protein coding gene Chr8:10514116-10625107 (-)
CBA/J ENSMUSG00210035231
 protein coding gene Chr8:10492938-10603567 (-)
DBA/2J ENSMUSG00185006185
 protein coding gene Chr8:10625684-10736310 (-)
FVB/NJ ENSMUSG00205029159
 protein coding gene Chr8:10518400-10629047 (-)
JF1/MsJ ENSUMUG00000023045
 protein coding gene Chr8:10641939-10758776 (-)
LP/J ENSMUSG00230023138
 protein coding gene Chr8:12800439-12917244 (-)
NOD/ShiLtJ ENSMUSG00190036348
 protein coding gene Chr8:10617759-10728398 (-)
NZO/HlLtJ ENSMUSG00225042132
 protein coding gene Chr8:20670304-20780941 (-)
PWK/PhJ ENSLUMG00010029737
 protein coding gene Chr8:10568869-10678984 (-)
SPRET/EiJ ENSMSPGG00010052274
 protein coding gene Chr8:10682671-10795142 (-)
WSB/EiJ ENSIUOG00005018701
 protein coding gene Chr8:10523364-10633918 (-)



Homology
more
  • Human Ortholog
    RASA3, RAS p21 protein activator 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASA3, RAS p21 protein activator 3
  • Synonyms
    GAP1IP4BP, GAPIII
  • Links
    NCBI Gene ID: 22821
    UniProt: Q14644

  • Chr Location
    13q34; chr13:113977783-114132775 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rasa3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 7 alleles in 11 genetic backgrounds
    4 phenotypes from multigenic genotypes
    1 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation die at E12.5-13.5 of massive subcutaneous and intraparenchymal hemorrhage, probably due to underdeveloped adherens junctions between capillary endothelial cells. At E12.5, edema and severe hemorrhaging is frequently observed in the brain and/or rump.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    71
  • cDNA Data
    121
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19414 NCBI Gene Model | MGI Sequence Detail 110373 C57BL/6J ±  kb
    transcript NM_009025 RefSeq | MGI Sequence Detail 4118 ZRU/MplStud  
    polypeptide Q60790 UniProt | EBI | MGI Sequence Detail 834 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 124
      cDNA 122
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14301, MGI:2142514, MGI:2142874, MGI:3575138, MGI:98236
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 6
      Phenotypes 24
    • Earliest
      J:10670 Peters LL, et al., Heritable severe combined anemia and thrombocytopenia in the mouse: description of the disease and successful therapy. Blood. 1990 Aug 15;76(4):745-54
    • Latest
      J:391246 Park C, et al., A Rasa3-Galphai signaling axis orchestrates B lymphocyte trafficking into and through lymphoid organs. Cell Rep. 2026 Apr 9;45(4):117243
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory