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Rasa3
Gene Detail
 Symbol
Name
ID
Rasa3
RAS p21 protein activator 3
MGI:1197013
Synonyms GAPIII, GAPIII activator 3, Ras GTPase-activating protein III, R-Ras gap, scat
Feature Type protein coding gene
Genetic Map
Chromosome 8
6.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:13566950-13677603 bp, - strand
From VEGA annotation of GRCm38

  110654 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7217  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rasa3

Human
homologs
Human Homolog RASA3, RAS p21 protein activator 3
NCBI Gene ID 22821
neXtProt AC  NX_Q14644
Human Synonyms  GAP1IP4BP, GAPIII
Human Chr (Location)  13q34; chr13:113977783-114132620 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation die at E12.5-13.5 of massive subcutaneous and intraparenchymal hemorrhage, probably due to underdeveloped adherens junctions between capillary endothelial cells. At E12.5, edema and severe hemorrhaging is frequently observed in the brain and/or rump.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process calcium ion transmembrane transport, intracellular signal transduction, ...
Component cytoplasm, intracellular, ...
Function calcium-release channel activity, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (173)    Tissues (27)    Images (34)
Theiler Stages: 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 171
RT-PCR 2
cDNA source data(120)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(123) cDNA(121) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029877 (Evidence)
Ensembl Gene ModelENSMUSG00000031453 (Evidence)
Entrez Gene19414 (Evidence)
UniGene18517
DFCITC1572535, TC1591996, TC1640983
DoTSDT.101319334, DT.101736381, DT.493613
NIA Mouse Gene IndexU029604
Consensus CDS ProjectCCDS40234.1
International Mouse Knockout Project StatusRasa3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029877 VEGA Gene Model | MGI Sequence Detail 110654 C57BL/6J ±  kb
transcript OTTMUST00000074137 VEGA | MGI Sequence Detail 4402 Not Applicable 
polypeptide OTTMUSP00000038486 VEGA | MGI Sequence Detail 834 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(1217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001936 Ras GTPase-activating protein
InterPro IPR023152 Ras GTPase-activating protein, conserved site
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001562 Zinc finger, Btk motif
Protein Ontology PR:000013745 ras GTPase-activating protein 3
References (Earliest) J:10670 Peters LL, et al., Heritable severe combined anemia and thrombocytopenia in the mouse: description of the disease and successful therapy. Blood. 1990 Aug 15;76(4):745-54
(Latest) J:186485 Blanc L, et al., Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12099-104
All references(53)
Other
accession IDs
MGD-MRK-14301, MGI:2142514, MGI:2142874, MGI:98236

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory