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Aebp1
Gene Detail
Symbol

Name
ID
Aebp1
AE binding protein 1
MGI:1197012
Synonyms
ACLP
Feature Type
protein coding gene
Genetic Map
Chromosome 11
3.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:5861947-5872088 bp, + strand
From VEGA annotation of GRCm38

  10142 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:878  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: AEBP1
Gene Tree: Aebp1

Human
homologs
AEBP1, AE binding protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 165
neXtProt AC: NX_Q8IUX7

Human Synonyms: ACLP

Human Chr (Location): 7p13; chr7:44104320-44114565 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for one null allele exhibit neonatal lethality, abdominal wall herniation, extrusion of the abdominal organs, and defects in wound healing. Mice homozygous for another null allele exhibit embryonic lethality, decreased white adipose tissue, and resistance to diet-induced obesity.
 
Interactions
Aebp1 interacts with 41 markers (Mir27b, Mir96, Mir137, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (161)    Tissues (148)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 65
RNA in situ 96
cDNA source data(101)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aebp1    NEW 
Molecular
reagents
All nucleic(102) cDNA(102)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000005099 (Evidence)
Ensembl Gene Model ENSMUSG00000020473 (Evidence)
Entrez Gene 11568 (Evidence)
UniGene 4665
DFCI TC1573147, TC1614120, TC1680650, TC1766337
NIA Mouse Gene Index U012290
Consensus CDS Project CCDS24406.1
International Mouse Phenotyping Consortium Status Aebp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005099 VEGA Gene Model | MGI Sequence Detail 10142 C57BL/6J ±  kb
transcript OTTMUST00000011403 VEGA | MGI Sequence Detail 3831 Not Applicable 
polypeptide OTTMUSP00000005314 VEGA | MGI Sequence Detail 1128 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008969 Carboxypeptidase-like, regulatory domain
InterPro IPR014766 Carboxypeptidase, regulatory domain
InterPro IPR000421 Coagulation factor 5/8 C-terminal domain
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000834 Peptidase M14, carboxypeptidase A
Protein Ontology PR:000003797 adipocyte enhancer-binding protein 1
References
(Earliest) J:37008 He GP, et al., A eukaryotic transcriptional repressor with carboxypeptidase activity. Nature. 1995 Nov 2;378(6552):92-6
(Latest) J:192643 Holloway RW, et al., Stromal adipocyte enhancer-binding protein (AEBP1) promotes mammary epithelial cell hyperplasia via proinflammatory and hedgehog signaling. J Biol Chem. 2012 Nov 9;287(46):39171-81
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory