Cd200
Gene Detail

Symbol Name ID

Cd200 CD200 antigen MGI:1196990

Synonyms

Mox2, MRC OX-2, OX2

Feature Type

protein coding gene

Genetic Map

Chromosome 16

29.53 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:45382135-45409053 bp, - strand From VEGA annotation of GRCm38   26919 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4344  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: OX-2 membrane glycoprotein
Gene Tree: Cd200

Human homologs

Human Homolog		CD200, CD200 molecule
NCBI Gene ID		4345
neXtProt AC		NX_P41217
Human Synonyms		MOX1, MOX2, MRC, OX-2
Human Chr (Location)		3q12-q13; chr3:112051916-112081659 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene have increased levels of all macrophage lineages. Macrophage are activated and mice display an increased susceptibility to autoimmune disease.

 
Human Diseases Modeled Using Mouse Cd200 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Component	integral to membrane, membrane, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (259)    Tissues (60)    Images (38)
Theiler Stages: 19, 21, 23, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	252

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(8) cDNA(13)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035902 (Evidence)
Ensembl Gene Model	ENSMUSG00000022661 (Evidence)
Entrez Gene	17470 (Evidence)
DFCI	TC1578031, TC1593401, TC1738311
DoTS	DT.101390520, DT.101712043, DT.87072397
Consensus CDS Project	CCDS49860.1
International Mouse Knockout Project Status	Cd200

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035902	VEGA Gene Model | MGI Sequence Detail	26919	C57BL/6J
transcript	OTTMUST00000092062	VEGA | MGI Sequence Detail	2347	Not Applicable
polypeptide	OTTMUSP00000050797	VEGA | MGI Sequence Detail	278	Not Applicable

All sequences(59) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(255 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013162	CD80-like, immunoglobulin C2-set
InterPro	IPR013151	Immunoglobulin
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003596	Immunoglobulin V-set, subgroup
Protein Ontology	PR:000001829	OX-2 membrane glycoprotein

References

(Earliest) J:44890 Chen Z, et al., Cloning and characterization of the murine homologue of the rat/human MRC OX-2 gene. Biochim Biophys Acta. 1997 Nov 28;1362(1):6-10
(Latest) J:194339 Li Y, et al., Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2324-9
All references(51)