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Cd200
Gene Detail
Symbol

Name
ID
Cd200
CD200 antigen
MGI:1196990
Synonyms
Mox2, MRC OX-2, OX2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
29.53 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:45382135-45409053 bp, - strand
From VEGA annotation of GRCm38

  26919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4344  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: OX-2 membrane glycoprotein
Gene Tree: Cd200

Human
homologs
Human Homolog CD200, CD200 molecule
NCBI Gene ID 4345
neXtProt AC  NX_P41217
Human Synonyms  MOX1, MOX2, MRC, OX-2
Human Chr (Location)  3q13.2; chr3:112332347-112362812 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have increased levels of all macrophage lineages. Macrophage are activated and mice display an increased susceptibility to autoimmune disease.
 
Human Diseases Modeled Using Mouse Cd200 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Cd200 interacts with 217 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component integral component of membrane, membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (274)    Tissues (76)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 267
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(8) cDNA(14)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035902 (Evidence)
Ensembl Gene ModelENSMUSG00000022661 (Evidence)
Entrez Gene17470 (Evidence)
DFCITC1578031, TC1593401, TC1738311
DoTSDT.101390520, DT.101712043, DT.87072397
PDB4BFI
Consensus CDS ProjectCCDS49860.1
International Mouse Knockout Project StatusCd200
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035902 VEGA Gene Model | MGI Sequence Detail 26919 C57BL/6J ±  kb
transcript OTTMUST00000092062 VEGA | MGI Sequence Detail 2347 Not Applicable 
polypeptide OTTMUSP00000050797 VEGA | MGI Sequence Detail 278 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(3) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(359 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003596 Immunoglobulin V-set, subgroup
Protein Ontology PR:000001829 OX-2 membrane glycoprotein
References
(Earliest) J:44890 Chen Z, et al., Cloning and characterization of the murine homologue of the rat/human MRC OX-2 gene. Biochim Biophys Acta. 1997 Nov 28;1362(1):6-10
(Latest) J:201380 Cox FF, et al., The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner. Neuroscience. 2013 Apr 3;235:141-8
All references(55)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory