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Tcea3 Gene Detail
Summary
  • Symbol
    Tcea3
  • Name
    transcription elongation factor A (SII), 3
  • Synonyms
    S-II, SII-K1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196908
    NCBI Gene: 21401
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:136247935-136274903 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 68.34 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    295 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196908
protein coding gene Chr4:136247729-136274903 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028963
protein coding gene Chr4:138780131-138812221 (+)
A/J MGP_AJ_G0028922
protein coding gene Chr4:132880919-132908386 (+)
AKR/J MGP_AKRJ_G0028874
protein coding gene Chr4:136726074-136753146 (+)
BALB/cJ MGP_BALBcJ_G0028946
protein coding gene Chr4:133543434-133570533 (+)
C3H/HeJ MGP_C3HHeJ_G0028660
protein coding gene Chr4:136999070-137027854 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029387
protein coding gene Chr4:143708683-143739715 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026658
protein coding gene Chr4:125916314-125945173 (+)
CAST/EiJ MGP_CASTEiJ_G0028092
protein coding gene Chr4:135140474-135176494 (+)
CBA/J MGP_CBAJ_G0028625
protein coding gene Chr4:147642935-147680236 (+)
DBA/2J MGP_DBA2J_G0028774
protein coding gene Chr4:133298530-133326615 (+)
FVB/NJ MGP_FVBNJ_G0028741
protein coding gene Chr4:132242069-132273562 (+)
LP/J MGP_LPJ_G0028873
protein coding gene Chr4:138873918-138903454 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028767
protein coding gene Chr4:151887684-151917396 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029425
protein coding gene Chr4:137180114-137210273 (+)
PWK/PhJ MGP_PWKPhJ_G0027812
protein coding gene Chr4:130073614-130105191 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027638
protein coding gene Chr4:133001189-133031472 (+)
WSB/EiJ MGP_WSBEiJ_G0028170
protein coding gene Chr4:137351209-137381518 (+)



Homology
more
  • Human Ortholog
    TCEA3, transcription elongation factor A3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TCEA3, transcription elongation factor A3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TFIIS, TFIIS.H
  • Links
    NCBI Gene ID: 6920
    neXtProt AC: NX_O75764
    UniProt: O75764

  • Chr Location
    1p36.12; chr1:23379953-23424779 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 21401 NCBI Gene Model | MGI Sequence Detail 26969 C57BL/6J ±  kb
transcript NM_011542 RefSeq | MGI Sequence Detail 1247 C57BL/6  
polypeptide P23881 UniProt | EBI | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016159 transcription elongation factor A protein 3
  • PDB
  • InterPro Domains
    IPR035441 TFIIS/LEDGF domain superfamily
    IPR035100 Transcription elongation factor, IIS-type
    IPR003618 Transcription elongation factor S-II, central domain
    IPR036575 Transcription elongation factor S-II, central domain superfamily
    IPR006289 Transcription elongation factor, TFIIS
    IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
    IPR017923 Transcription factor IIS, N-terminal
    IPR001222 Zinc finger, TFIIS-type
Molecular
Reagents
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  • All nucleic 39
    cDNA 36
    Primer pair 2
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 48
    Developmental Gene Expression 8
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:33182 Hirashima S, et al., Molecular cloning and characterization of cDNA for eukaryotic transcription factor S-II. J Biol Chem. 1988 Mar 15;263(8):3858-63
  • Latest
    J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory